A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents

Background Allergic diseases often occur in combination (multimorbidity). Human blood transcriptome studies have not addressed multimorbidity. Large‐scale gene expression data were combined to retrieve biomarkers and signaling pathways to disentangle allergic multimorbidity phenotypes. Methods Integ...

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Bibliographic Details
Published in:	Allergy (Copenhagen) Vol. 75; no. 12; pp. 3248 - 3260
Main Authors:	Lemonnier, Nathanaël, Melén, Erik, Jiang, Yale, Joly, Stéphane, Ménard, Camille, Aguilar, Daniel, Acosta‐Perez, Edna, Bergström, Anna, Boutaoui, Nadia, Bustamante, Mariona, Canino, Glorisa, Forno, Erick, Ramon González, Juan, Garcia‐Aymerich, Judith, Gruzieva, Olena, Guerra, Stefano, Heinrich, Joachim, Kull, Inger, Ibarluzea Maurolagoitia, Jesús, Santa‐Marina Rodriguez, Loreto, Thiering, Elisabeth, Wickman, Magnus, Akdis, Cezmi, Akdis, Mübeccel, Chen, Wei, Keil, Thomas, Koppelman, Gerard H., Siroux, Valérie, Xu, Cheng‐Jian, Hainaut, Pierre, Standl, Marie, Sunyer, Jordi, Celedón, Juan C., Maria Antó, Josep, Bousquet, Jean
Format:	Journal Article
Language:	English
Published:	Denmark Blackwell Publishing Ltd 01.12.2020 Wiley
Subjects:	Adolescent Allergic diseases Asthma Asthma - epidemiology Asthma - genetics Atopic dermatitis Blood Child Children Comorbidity Dermatitis Eczema Gene expression Humans Hypersensitivity Hypersensitivity - epidemiology Hypersensitivity - genetics Immune response Interleukin 1 Interleukin 5 Leukocytes (eosinophilic) Life Sciences Multimorbidity Phenotypes Rhinitis Rhinitis - epidemiology Rhinitis - genetics Rhinitis, Allergic - epidemiology Rhinitis, Allergic - genetics Ribonucleic acid RNA Signal transduction Teenagers Transcriptome Transcriptomics multimorbidity transcriptomics atopic dermatitis asthma rhinitis
ISSN:	0105-4538, 1398-9995, 1398-9995
Online Access:	Get full text
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