Increased risk of adverse drug reactions by higher linezolid dose per weight in multidrug-resistant tuberculosis

Linezolid treatment has a high risk of toxicity and adverse drug reactions (ADR) are frequent. Few studies have investigated risk factors of major ADRs separately, therefore, we aimed to evaluate major ADRs including peripheral neuropathy in relation to risk factors and drug concentration levels of...

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Bibliographic Details
Published in:	International journal of antimicrobial agents Vol. 64; no. 4; p. 107302
Main Authors:	Kuhlin, Johanna, Davies Forsman, Lina, Osman, Aisha, Skagerberg, Magdalena, Jonsson, Jerker, Groenheit, Ramona, Mansjö, Mikael, Werngren, Jim, Alffenaar, Jan-Willem, Schön, Thomas, Bruchfeld, Judith
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.10.2024
Subjects:	adverse drug reactions Anaemia Drug concentrations Infectious Disease Leukopenia Linezolid MDR-TB Peripheral neuropathy Thrombocytopenia Linezolid Thrombocytopenia CTCAE MGIT Leukopenia Anaemia MIC MDR-TB HR Peripheral neuropathy ADR AUC adverse drug reactions Drug concentrations BMI WHO area under the concentration time-curve adverse drug reaction Common Terminology Criteria for Adverse Events World Health Organization body mass index multidrug-resistant tuberculosis minimum inhibitory concentration Mycobacterial Growth Indicator Tube hazard ratio leukopenia linezolid anaemia thrombocytopenia drug concentrations peripheral neuropathy
ISSN:	0924-8579, 1872-7913, 1872-7913
Online Access:	Get full text
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