Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

Mass spectrometry-based metabolomics approaches can enable detection and quantification of many thousands of metabolite features simultaneously. However, compound identification and reliable quantification are greatly complicated owing to the chemical complexity and dynamic range of the metabolome....

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Vydané v:Nature methods Ročník 18; číslo 7; s. 747 - 756
Hlavní autori: Alseekh, Saleh, Aharoni, Asaph, Brotman, Yariv, Contrepois, Kévin, D'Auria, John, Ewald, Jan, C Ewald, Jennifer, Fraser, Paul D, Giavalisco, Patrick, Hall, Robert D, Heinemann, Matthias, Link, Hannes, Luo, Jie, Neumann, Steffen, Nielsen, Jens, Perez de Souza, Leonardo, Saito, Kazuki, Sauer, Uwe, Schroeder, Frank C, Schuster, Stefan, Siuzdak, Gary, Skirycz, Aleksandra, Sumner, Lloyd W, Snyder, Michael P, Tang, Huiru, Tohge, Takayuki, Wang, Yulan, Wen, Weiwei, Wu, Si, Xu, Guowang, Zamboni, Nicola, Fernie, Alisdair R
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Nature Publishing Group 01.07.2021
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ISSN:1548-7091, 1548-7105, 1548-7105
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Abstract Mass spectrometry-based metabolomics approaches can enable detection and quantification of many thousands of metabolite features simultaneously. However, compound identification and reliable quantification are greatly complicated owing to the chemical complexity and dynamic range of the metabolome. Simultaneous quantification of many metabolites within complex mixtures can additionally be complicated by ion suppression, fragmentation and the presence of isomers. Here we present guidelines covering sample preparation, replication and randomization, quantification, recovery and recombination, ion suppression and peak misidentification, as a means to enable high-quality reporting of liquid chromatography- and gas chromatography-mass spectrometry-based metabolomics-derived data.
AbstractList Mass spectrometry-based metabolomics approaches can enable detection and quantification of many thousands of metabolite features simultaneously. However, compound identification and reliable quantification are greatly complicated owing to the chemical complexity and dynamic range of the metabolome. Simultaneous quantification of many metabolites within complex mixtures can additionally be complicated by ion suppression, fragmentation and the presence of isomers. Here we present guidelines covering sample preparation, replication and randomization, quantification, recovery and recombination, ion suppression and peak misidentification, as a means to enable high-quality reporting of liquid chromatography- and gas chromatography-mass spectrometry-based metabolomics-derived data.
Mass spectrometry-based metabolomics approaches can enable detection and quantification of many thousands of metabolite features simultaneously. However, compound identification and reliable quantification are greatly complicated owing to the chemical complexity and dynamic range of the metabolome. Simultaneous quantification of many metabolites within complex mixtures can additionally be complicated by ion suppression, fragmentation and the presence of isomers. Here we present guidelines covering sample preparation, replication and randomization, quantification, recovery and recombination, ion suppression and peak misidentification, as a means to enable high-quality reporting of liquid chromatography– and gas chromatography–mass spectrometry-based metabolomics-derived data.This Perspective, from a large group of metabolomics experts, provides best practices and simplified reporting guidelines for practitioners of liquid chromatography– and gas chromatography–mass spectrometry-based metabolomics.
Mass spectrometry-based metabolomics approaches can enable detection and quantification of many thousands of metabolite features simultaneously. However, compound identification and reliable quantification are greatly complicated owing to the chemical complexity and dynamic range of the metabolome. Simultaneous quantification of many metabolites within complex mixtures can additionally be complicated by ion suppression, fragmentation and the presence of isomers. Here we present guidelines covering sample preparation, replication and randomization, quantification, recovery and recombination, ion suppression and peak misidentification, as a means to enable high-quality reporting of liquid chromatography- and gas chromatography-mass spectrometry-based metabolomics-derived data.Mass spectrometry-based metabolomics approaches can enable detection and quantification of many thousands of metabolite features simultaneously. However, compound identification and reliable quantification are greatly complicated owing to the chemical complexity and dynamic range of the metabolome. Simultaneous quantification of many metabolites within complex mixtures can additionally be complicated by ion suppression, fragmentation and the presence of isomers. Here we present guidelines covering sample preparation, replication and randomization, quantification, recovery and recombination, ion suppression and peak misidentification, as a means to enable high-quality reporting of liquid chromatography- and gas chromatography-mass spectrometry-based metabolomics-derived data.
Author Fraser, Paul D
Link, Hannes
Giavalisco, Patrick
Hall, Robert D
Perez de Souza, Leonardo
Alseekh, Saleh
Nielsen, Jens
Wu, Si
Schroeder, Frank C
Tohge, Takayuki
Siuzdak, Gary
Brotman, Yariv
Tang, Huiru
D'Auria, John
Fernie, Alisdair R
Xu, Guowang
Aharoni, Asaph
Snyder, Michael P
C Ewald, Jennifer
Saito, Kazuki
Neumann, Steffen
Heinemann, Matthias
Wang, Yulan
Ewald, Jan
Zamboni, Nicola
Luo, Jie
Contrepois, Kévin
Skirycz, Aleksandra
Sauer, Uwe
Sumner, Lloyd W
Schuster, Stefan
Wen, Weiwei
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  orcidid: 0000-0002-5512-9077
  surname: Heinemann
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  organization: Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands
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  organization: Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
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  organization: College of Tropical Crops, Hainan University, Haikou, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34239102$$D View this record in MEDLINE/PubMed
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Snippet Mass spectrometry-based metabolomics approaches can enable detection and quantification of many thousands of metabolite features simultaneously. However,...
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SubjectTerms Animals
Annotations
Best practice
Chromatography
Chromatography, Liquid
Complexity
Gas chromatography
Gas Chromatography-Mass Spectrometry
Guidelines
Humans
Ion recombination
Ions
Isomers
Liquid chromatography
Mass spectrometry
Mass Spectrometry - methods
Mass Spectrometry - standards
Mass spectroscopy
Metabolites
Metabolomics
Metabolomics - methods
Metabolomics - standards
Random Allocation
Recombination
Sample preparation
Scientific imaging
Specimen Handling
Spectroscopy
Workflow
Title Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices
URI https://www.ncbi.nlm.nih.gov/pubmed/34239102
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