Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin

The activity state of cofilin, which controls actin dynamics, is driven by a phosphorylation–dephosphorylation cycle. Phosphorylation of cofilin by LIM‐kinases results in its inactivation, a process supported by 14‐3‐3ζ and reversed by dephosphorylation by slingshot phosphatases. Here we report on a...

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Veröffentlicht in:	The EMBO journal Jg. 26; H. 19; S. 4189 - 4202
Hauptverfasser:	Han, Li, Stope, Matthias B, de Jesús, Maider López, Oude Weernink, Paschal A, Urban, Martina, Wieland, Thomas, Rosskopf, Dieter, Mizuno, Kensaku, Jakobs, Karl H, Schmidt, Martina
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Chichester, UK John Wiley & Sons, Ltd 03.10.2007 Nature Publishing Group UK Springer Nature B.V Nature Publishing Group
Schlagworte:	14-3-3 14-3-3 Proteins Actins - genetics Actins - metabolism Cell Line Cellular biology cofilin EMBO37 Gene Expression Humans Inactivation Lim Kinases LIM-kinase1 Molecular biology Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism phospholipase D Phospholipase D - genetics Phospholipase D - metabolism Phosphorylation Protein Binding - physiology Protein Kinases - genetics Protein Kinases - metabolism Protein Processing, Post-Translational - physiology Receptors, Muscarinic - genetics Receptors, Muscarinic - metabolism Signal transduction slingshot phospholipase D slingshot cofilin LIM‐kinase1 14‐3‐3
ISSN:	0261-4189, 1460-2075
Online-Zugang:	Volltext
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