Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

Microbiome-wide association studies on large population cohorts have highlighted associations between the gut microbiome and complex traits, including type 2 diabetes (T2D) and obesity 1 . However, the causal relationships remain largely unresolved. We leveraged information from 952 normoglycemic in...

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Vydáno v:	Nature genetics Ročník 51; číslo 4; s. 600 - 605
Hlavní autoři:	Sanna, Serena, van Zuydam, Natalie R., Mahajan, Anubha, Kurilshikov, Alexander, Vich Vila, Arnau, Võsa, Urmo, Mujagic, Zlatan, Masclee, Ad A. M., Jonkers, Daisy M. A. E., Oosting, Marije, Joosten, Leo A. B., Netea, Mihai G., Franke, Lude, Zhernakova, Alexandra, Fu, Jingyuan, Wijmenga, Cisca, McCarthy, Mark I.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.04.2019 Nature Publishing Group
Témata:	45 631/208 692/308/174 692/699/2743/137 692/699/2743/393 Abnormalities Adolescent Adult Aged Aged, 80 and over Agriculture Animal Genetics and Genomics Anthropometry Biomedical and Life Sciences Biomedicine Cancer Research Chains Consortia Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Digestive system Disease Esters Fatty acids Fatty Acids, Volatile - genetics Feces Female Gastrointestinal Microbiome - genetics Gene Function Genetic research Genomes Genomics Genotype Genotyping Glucose Glucose tolerance Glucose Tolerance Test - methods Gut microbiota Human Genetics Humans Insulin Intestinal microflora Letter Male Metabolic diseases Metabolic Diseases - genetics Metabolic disorders Metabolism Microbiomes Microbiota Microbiota (Symbiotic organisms) Middle Aged Netherlands Nucleotide sequence Obesity Population studies Principal components analysis Production capacity Propionic acid Statistics Studies Type 2 diabetes Young Adult Netherlands United Kingdom > UK
ISSN:	1061-4036, 1546-1718, 1546-1718
On-line přístup:	Získat plný text
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