Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release

Background Sepsis is a life-threatening condition that often leads to severe complications, including acute lung injury (ALI), which carries high morbidity and mortality in critically ill patients. Melatonin (Mel) has shown significant protective effects against sepsis-induced ALI, but its precise m...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Jg. 31; H. 1; S. 176 - 15
Hauptverfasser:	Peng, Yuce, Xu, Jia, Wei, Lingyu, Luo, Minghao, Chen, Shenglong, Wei, Xuebiao, Luo, Suxin, Su, Zedazhong, Wang, Zhonghua
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 07.05.2025 BMC
Schlagworte:	Acute Lung Injury - blood Acute Lung Injury - drug therapy Acute Lung Injury - etiology Acute Lung Injury - metabolism Acute Lung Injury - pathology ALI Animals Biomarkers Biomedical and Life Sciences Biomedicine Cytokines - blood Cytokines - metabolism Disease Models, Animal DNA, Mitochondrial - blood DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Male Melatonin Melatonin - pharmacology Melatonin - therapeutic use Mice Mice, Inbred C57BL Molecular Medicine mtDNA-STING Necroptosis Necroptosis - drug effects Sepsis Sepsis - complications Sepsis - drug therapy Signal Transduction - drug effects Sepsis Melatonin mtDNA-STING Necroptosis ALI
ISSN:	1528-3658, 1076-1551, 1528-3658
Online-Zugang:	Volltext
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