Signatures of negative selection in the genetic architecture of human complex traits

We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero effects), and the relationship between SNP effect size and minor allele frequency for complex traits in conventionally unrelat...

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Bibliographic Details
Published in:	Nature genetics Vol. 50; no. 5; pp. 746 - 753
Main Authors:	Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M., Yang, Jian
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.05.2018 Nature Publishing Group
Subjects:	38 45 45/43 631/208/205/2138 631/208/457 Agriculture Alleles Analysis Animal Genetics and Genomics Anthropometry Architecture Bayes Theorem Bayesian analysis Biomedical and Life Sciences Biomedicine Cancer Research Computer simulation Consortia Evolution Evolution (Biology) Gene expression Gene frequency Gene Frequency - genetics Gene Function Genetic aspects Genetic diversity Genetic polymorphisms Genetic variance Genome-Wide Association Study - methods Genomes Genomics Genotype Genotype & phenotype Heritability Human Genetics Humans Linear Models Methods Models, Genetic Multifactorial Inheritance - genetics Mutation Natural selection Negative selection Parameter estimation Phenotype Phenotypic variations Polymorphism Polymorphism, Single Nucleotide - genetics Quantitative Trait, Heritable Selection, Genetic - genetics Signatures Single nucleotide polymorphisms Single-nucleotide polymorphism Type 2 diabetes United Kingdom > UK
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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