Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

Determining the genetic bases of age-related disease remains a major challenge requiring a spectrum of approaches from human and clinical genetics to the utilization of model organism studies. Here we report a large-scale genetic screen in mice employing a phenotype-driven discovery platform to iden...

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Veröffentlicht in:	Nature communications Jg. 7; H. 1; S. 12444 - 13
Hauptverfasser:	Potter, Paul K., Bowl, Michael R., Jeyarajan, Prashanthini, Wisby, Laura, Blease, Andrew, Goldsworthy, Michelle E., Simon, Michelle M., Greenaway, Simon, Michel, Vincent, Barnard, Alun, Aguilar, Carlos, Agnew, Thomas, Banks, Gareth, Blake, Andrew, Chessum, Lauren, Dorning, Joanne, Falcone, Sara, Goosey, Laurence, Harris, Shelley, Haynes, Andy, Heise, Ines, Hillier, Rosie, Hough, Tertius, Hoslin, Angela, Hutchison, Marie, King, Ruairidh, Kumar, Saumya, Lad, Heena V., Law, Gemma, MacLaren, Robert E., Morse, Susan, Nicol, Thomas, Parker, Andrew, Pickford, Karen, Sethi, Siddharth, Starbuck, Becky, Stelma, Femke, Cheeseman, Michael, Cross, Sally H., Foster, Russell G., Jackson, Ian J., Peirson, Stuart N., Thakker, Rajesh V., Vincent, Tonia, Scudamore, Cheryl, Wells, Sara, El-Amraoui, Aziz, Petit, Christine, Acevedo-Arozena, Abraham, Nolan, Patrick M., Cox, Roger, Mallon, Anne-Marie, Brown, Steve D. M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 18.08.2016 Nature Publishing Group Nature Portfolio
Schlagworte:	631/1647/334/1874/345 631/208/191/1908 64 64/60 692/699 Age Aging Aging - genetics Animals Cochlea - metabolism Diabetes Disease Disease Models, Animal Epithelium - ultrastructure Evoked Potentials, Auditory, Brain Stem - physiology Female Females Genes Genetic Testing Genetics Genomes Genotype & phenotype Hearing - genetics Hearing loss Hospitals Humanities and Social Sciences Life Sciences Male Males Mice, Inbred C57BL multidisciplinary Mutagenesis Mutagenesis - genetics Mutation Mutation - genetics Ophthalmology Pedigree Phenotype Physiology Rheumatology Science Science (multidisciplinary) United Kingdom > UK France
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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