International Histopathology Consensus for Unilateral Primary Aldosteronism
Abstract Objective Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Context Unilateral PA is the most common surgically treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone syntha...
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| Vydané v: | The journal of clinical endocrinology and metabolism Ročník 106; číslo 1; s. 42 - 54 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
US
Oxford University Press
01.01.2021
Copyright Oxford University Press |
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| ISSN: | 0021-972X, 1945-7197, 1945-7197 |
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| Abstract | Abstract
Objective
Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA).
Context
Unilateral PA is the most common surgically treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals.
Patients and Methods
Surgically removed adrenals (n = 37) from 90 patients operated from 2015 to 2018 in Munich, Germany, were selected to represent the broad histologic spectrum of unilateral PA. Five pathologists (Group 1 from Germany, Italy, and Japan) evaluated the histopathology of hematoxylin-eosin (HE) and CYP11B2 immunostained sections, and a consensus was established to define the identifiable features. The consensus was subsequently used by 6 additional pathologists (Group 2 from Australia, Brazil, Canada, Japan, United Kingdom, United States) for the assessment of all adrenals with disagreement for histopathologic diagnoses among group 1 pathologists.
Results
Consensus was achieved to define histopathologic features associated with PA. Use of CYP11B2 immunostaining resulted in a change of the original HE morphology-driven diagnosis in 5 (14%) of 37 cases. Using the consensus criteria, group 2 pathologists agreed for the evaluation of 11 of the 12 cases of disagreement among group 1 pathologists.
Conclusion
The HISTALDO (histopathology of primary aldosteronism) consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production. |
|---|---|
| AbstractList | Abstract
Objective
Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA).
Context
Unilateral PA is the most common surgically treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals.
Patients and Methods
Surgically removed adrenals (n = 37) from 90 patients operated from 2015 to 2018 in Munich, Germany, were selected to represent the broad histologic spectrum of unilateral PA. Five pathologists (Group 1 from Germany, Italy, and Japan) evaluated the histopathology of hematoxylin-eosin (HE) and CYP11B2 immunostained sections, and a consensus was established to define the identifiable features. The consensus was subsequently used by 6 additional pathologists (Group 2 from Australia, Brazil, Canada, Japan, United Kingdom, United States) for the assessment of all adrenals with disagreement for histopathologic diagnoses among group 1 pathologists.
Results
Consensus was achieved to define histopathologic features associated with PA. Use of CYP11B2 immunostaining resulted in a change of the original HE morphology-driven diagnosis in 5 (14%) of 37 cases. Using the consensus criteria, group 2 pathologists agreed for the evaluation of 11 of the 12 cases of disagreement among group 1 pathologists.
Conclusion
The HISTALDO (histopathology of primary aldosteronism) consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production. Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA).OBJECTIVEDevelop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA).Unilateral PA is the most common surgically treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals.CONTEXTUnilateral PA is the most common surgically treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals.Surgically removed adrenals (n = 37) from 90 patients operated from 2015 to 2018 in Munich, Germany, were selected to represent the broad histologic spectrum of unilateral PA. Five pathologists (Group 1 from Germany, Italy, and Japan) evaluated the histopathology of hematoxylin-eosin (HE) and CYP11B2 immunostained sections, and a consensus was established to define the identifiable features. The consensus was subsequently used by 6 additional pathologists (Group 2 from Australia, Brazil, Canada, Japan, United Kingdom, United States) for the assessment of all adrenals with disagreement for histopathologic diagnoses among group 1 pathologists.PATIENTS AND METHODSSurgically removed adrenals (n = 37) from 90 patients operated from 2015 to 2018 in Munich, Germany, were selected to represent the broad histologic spectrum of unilateral PA. Five pathologists (Group 1 from Germany, Italy, and Japan) evaluated the histopathology of hematoxylin-eosin (HE) and CYP11B2 immunostained sections, and a consensus was established to define the identifiable features. The consensus was subsequently used by 6 additional pathologists (Group 2 from Australia, Brazil, Canada, Japan, United Kingdom, United States) for the assessment of all adrenals with disagreement for histopathologic diagnoses among group 1 pathologists.Consensus was achieved to define histopathologic features associated with PA. Use of CYP11B2 immunostaining resulted in a change of the original HE morphology-driven diagnosis in 5 (14%) of 37 cases. Using the consensus criteria, group 2 pathologists agreed for the evaluation of 11 of the 12 cases of disagreement among group 1 pathologists.RESULTSConsensus was achieved to define histopathologic features associated with PA. Use of CYP11B2 immunostaining resulted in a change of the original HE morphology-driven diagnosis in 5 (14%) of 37 cases. Using the consensus criteria, group 2 pathologists agreed for the evaluation of 11 of the 12 cases of disagreement among group 1 pathologists.The HISTALDO (histopathology of primary aldosteronism) consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production.CONCLUSIONThe HISTALDO (histopathology of primary aldosteronism) consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production. Objective Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Context Unilateral PA is the most common surgically treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals. Patients and Methods Surgically removed adrenals (n = 37) from 90 patients operated from 2015 to 2018 in Munich, Germany, were selected to represent the broad histologic spectrum of unilateral PA. Five pathologists (Group 1 from Germany, Italy, and Japan) evaluated the histopathology of hematoxylin-eosin (HE) and CYP11B2 immunostained sections, and a consensus was established to define the identifiable features. The consensus was subsequently used by 6 additional pathologists (Group 2 from Australia, Brazil, Canada, Japan, United Kingdom, United States) for the assessment of all adrenals with disagreement for histopathologic diagnoses among group 1 pathologists. Results Consensus was achieved to define histopathologic features associated with PA. Use of CYP11B2 immunostaining resulted in a change of the original HE morphology-driven diagnosis in 5 (14%) of 37 cases. Using the consensus criteria, group 2 pathologists agreed for the evaluation of 11 of the 12 cases of disagreement among group 1 pathologists. Conclusion The HISTALDO (histopathology of primary aldosteronism) consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production. Objective: Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Context: Unilateral PA is the most common surgically treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals. Patients and Methods: Surgically removed adrenals (n = 37) from 90 patients operated from 2015 to 2018 in Munich, Germany, were selected to represent the broad histologic spectrum of unilateral PA. Five pathologists (Group 1 from Germany, Italy, and Japan) evaluated the histopathology of hematoxylin-eosin (HE) and CYP11B2 immunostained sections, and a consensus was established to define the identifiable features. The consensus was subsequently used by 6 additional pathologists (Group 2 from Australia, Brazil, Canada, Japan, United Kingdom, United States) forthe assessment of all adrenals with disagreement for histopathologic diagnoses among group 1 pathologists. Results: Consensus was achieved to define histopathologic features associated with PA. Use of CYP11B2 immunostaining resulted in a change of the original HE morphology-driven diagnosis in 5 (14%) of 37 cases. Using the consensus criteria, group 2 pathologists agreed for the evaluation of 11 of the 12 cases of disagreement among group 1 pathologists. Conclusion: The HISTALDO (histopathology of primary aldosteronism) consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production. KeyWords: primary aldosteronism, diagnostic histopathology, CYP11B2, adrenal gland, immunohistochemistry Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Unilateral PA is the most common surgically treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals. Surgically removed adrenals (n = 37) from 90 patients operated from 2015 to 2018 in Munich, Germany, were selected to represent the broad histologic spectrum of unilateral PA. Five pathologists (Group 1 from Germany, Italy, and Japan) evaluated the histopathology of hematoxylin-eosin (HE) and CYP11B2 immunostained sections, and a consensus was established to define the identifiable features. The consensus was subsequently used by 6 additional pathologists (Group 2 from Australia, Brazil, Canada, Japan, United Kingdom, United States) for the assessment of all adrenals with disagreement for histopathologic diagnoses among group 1 pathologists. Consensus was achieved to define histopathologic features associated with PA. Use of CYP11B2 immunostaining resulted in a change of the original HE morphology-driven diagnosis in 5 (14%) of 37 cases. Using the consensus criteria, group 2 pathologists agreed for the evaluation of 11 of the 12 cases of disagreement among group 1 pathologists. The HISTALDO (histopathology of primary aldosteronism) consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production. |
| Audience | Academic |
| Author | Zerbini, Maria Claudia Nogueira Papotti, Mauro Saeger, Wolfgang Yamazaki, Yuto Mete, Ozgur Marker, Alison Giordano, Thomas J Mulatero, Paolo Satoh, Fumitoshi Knösel, Thomas Rainey, William E Beuschlein, Felix Gomez-Sanchez, Celso E Burrello, Jacopo Schneider, Holger Lam, Alfred K Lenders, Jacques W M Williams, Tracy Ann Castellano, Isabella Sasano, Hironobu Reincke, Martin |
| AuthorAffiliation | Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy Endocrine Division, G.V. (Sonny) Montgomery VA Medical Center, and Department of Pharmacology and Toxicology and Medicine, University of Mississippi Medical Center, Jackson, MS, USA Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor Department of Pathology and Rogel Cancer Center, University of Michigan, Ann Arbor School of Medicine, Griffith University, Gold Coast, QLD, Australia Department of Histopathology, Cambridge University NHS Foundation Trust, Cambridge, UK Department of Pathology, University Health Network, Toronto, ON, Canada Department of Laboratory Medicine and Pathobiology, University of Toron |
| AuthorAffiliation_xml | – name: Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy Endocrine Division, G.V. (Sonny) Montgomery VA Medical Center, and Department of Pharmacology and Toxicology and Medicine, University of Mississippi Medical Center, Jackson, MS, USA Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor Department of Pathology and Rogel Cancer Center, University of Michigan, Ann Arbor School of Medicine, Griffith University, Gold Coast, QLD, Australia Department of Histopathology, Cambridge University NHS Foundation Trust, Cambridge, UK Department of Pathology, University Health Network, Toronto, ON, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan Departamento de Patologia, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zürich, Switzerland Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Department of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany Division of Pathology, Department of Medical Sciences, University of Turin, Turin, Italy Institute of Pathology, Ludwig-Maximilians-Universität München, Germany Department of Oncology, University of Turin, Turin, Italy Institute of Pathology, Universität Hamburg, Germany – name: 19 Department of Oncology, University of Turin , Turin, Italy – name: 13 Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich , Zürich, Switzerland – name: 16 Department of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden , Dresden, Germany – name: 17 Division of Pathology, Department of Medical Sciences, University of Turin , Turin, Italy – name: 18 Institute of Pathology, Ludwig-Maximilians-Universität München , Germany – name: 7 School of Medicine, Griffith University , Gold Coast, Australia – name: 15 Department of Internal Medicine, Radboud University Medical Center , Nijmegen, The Netherlands – name: 14 Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine , Sendai, Japan – name: 20 Institute of Pathology, Universität Hamburg , Germany – name: 5 Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan , Ann Arbor, MI, USA – name: 9 Department of Pathology, University Health Network , Toronto, Canada – name: 12 Departamento de Patologia, Faculdade de Medicina da Universidade de Sao Paulo , Sao Paulo, Brazil – name: 3 Endocrine Division, G.V. (Sonny) Montgomery VA Medical Center, and Department of Pharmacology and Toxicology and Medicine, University of Mississippi Medical Center , Jackson, MS, USA – name: 11 Department of Pathology, Tohoku University Graduate School of Medicine , Sendai, Japan – name: 8 Department of Histopathology, Cambridge University NHS Foundation Trust , Cambridge, UK – name: 1 Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München , Germany – name: 4 Department of Molecular and Integrative Physiology, University of Michigan , Ann Arbor, MI, USA – name: 6 Department of Pathology and Rogel Cancer Center, University of Michigan , Ann Arbor, MI, USA – name: 2 Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin , Turin, Italy – name: 10 Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, Canada |
| Author_xml | – sequence: 1 givenname: Tracy Ann orcidid: 0000-0002-2388-6444 surname: Williams fullname: Williams, Tracy Ann email: Tracy.Williams@med.uni-muenchen.de organization: Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany – sequence: 2 givenname: Celso E surname: Gomez-Sanchez fullname: Gomez-Sanchez, Celso E organization: Endocrine Division, G.V. (Sonny) Montgomery VA Medical Center, and Department of Pharmacology and Toxicology and Medicine, University of Mississippi Medical Center, Jackson, MS, USA – sequence: 3 givenname: William E surname: Rainey fullname: Rainey, William E organization: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA – sequence: 4 givenname: Thomas J surname: Giordano fullname: Giordano, Thomas J organization: Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA – sequence: 5 givenname: Alfred K surname: Lam fullname: Lam, Alfred K organization: School of Medicine, Griffith University, Gold Coast, Australia – sequence: 6 givenname: Alison surname: Marker fullname: Marker, Alison organization: Department of Histopathology, Cambridge University NHS Foundation Trust, Cambridge, UK – sequence: 7 givenname: Ozgur surname: Mete fullname: Mete, Ozgur organization: Department of Pathology, University Health Network, Toronto, Canada – sequence: 8 givenname: Yuto surname: Yamazaki fullname: Yamazaki, Yuto organization: Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 9 givenname: Maria Claudia Nogueira surname: Zerbini fullname: Zerbini, Maria Claudia Nogueira organization: Departamento de Patologia, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil – sequence: 10 givenname: Felix orcidid: 0000-0001-7826-3984 surname: Beuschlein fullname: Beuschlein, Felix organization: Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany – sequence: 11 givenname: Fumitoshi surname: Satoh fullname: Satoh, Fumitoshi organization: Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 12 givenname: Jacopo orcidid: 0000-0001-7884-7314 surname: Burrello fullname: Burrello, Jacopo organization: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy – sequence: 13 givenname: Holger surname: Schneider fullname: Schneider, Holger organization: Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany – sequence: 14 givenname: Jacques W M surname: Lenders fullname: Lenders, Jacques W M organization: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands – sequence: 15 givenname: Paolo orcidid: 0000-0002-5480-1116 surname: Mulatero fullname: Mulatero, Paolo organization: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy – sequence: 16 givenname: Isabella surname: Castellano fullname: Castellano, Isabella organization: Division of Pathology, Department of Medical Sciences, University of Turin, Turin, Italy – sequence: 17 givenname: Thomas surname: Knösel fullname: Knösel, Thomas organization: Institute of Pathology, Ludwig-Maximilians-Universität München, Germany – sequence: 18 givenname: Mauro surname: Papotti fullname: Papotti, Mauro organization: Department of Oncology, University of Turin, Turin, Italy – sequence: 19 givenname: Wolfgang surname: Saeger fullname: Saeger, Wolfgang organization: Institute of Pathology, Universität Hamburg, Germany – sequence: 20 givenname: Hironobu orcidid: 0000-0002-6600-8641 surname: Sasano fullname: Sasano, Hironobu email: hsasano@patholo2.med.tohoku.ac.jp organization: Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 21 givenname: Martin orcidid: 0000-0002-9817-9875 surname: Reincke fullname: Reincke, Martin organization: Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32717746$$D View this record in MEDLINE/PubMed |
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| Copyright | The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020 Copyright © Oxford University Press 2015 The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. COPYRIGHT 2021 Oxford University Press The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com |
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| Keywords | diagnostic histopathology adrenal gland immunohistochemistry CYP11B2 primary aldosteronism |
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Objective
Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA).... Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Unilateral PA is the most... Objective: Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Context:... Objective Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Context... Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA).OBJECTIVEDevelop a... |
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| SubjectTerms | Adrenal Glands - metabolism Adrenal Glands - pathology Adrenalectomy - methods Adrenalectomy - standards Adult Aldosterone Aldosterone synthase Clinical s Cohort Studies Consensus Corticosteroids Cytochrome P-450 Cytochrome P-450 CYP11B2 - metabolism Cytodiagnosis - methods Cytodiagnosis - standards Diagnosis Diagnostic Techniques, Endocrine - standards Female Germany Histological Techniques - standards Histopathology Humans Hyperaldosteronism Hyperaldosteronism - complications Hyperaldosteronism - diagnosis Hyperaldosteronism - surgery Hypertension Hypertension - diagnosis Hypertension - etiology Hypertension - surgery Immunohistochemistry Internationality Male Medical screening Middle Aged Nomenclature Practice Guidelines as Topic - standards Societies, Medical - standards |
| Title | International Histopathology Consensus for Unilateral Primary Aldosteronism |
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