Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid

Applications for fluoropolymers and PFOA include surface coatings for stain, oil, and water resistance on household products, carpets, textiles, and food packaging; personal care products; seals; coatings for cables and wires; and construction materials. Since the previous classification of PFOA (as...

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Veröffentlicht in:The lancet oncology Jg. 25; H. 1; S. 16 - 17
Hauptverfasser: Zahm, Shelia, Bonde, Jens Peter, Chiu, Weihsueh A, Hoppin, Jane, Kanno, Jun, Abdallah, Mohamed, Blystone, Chad R, Calkins, Miriam M, Dong, Guang-Hui, Dorman, David C, Fry, Rebecca, Guo, Huan, Haug, Line S, Hofmann, Jonathan N, Iwasaki, Motoki, Machala, Miroslav, Mancini, Francesca R, Maria-Engler, Silvya S, Møller, Peter, Ng, Jack C, Pallardy, Marc, Post, Gloria B, Salihovic, Samira, Schlezinger, Jennifer, Soshilov, Anatoly, Steenland, Kyle, Steffensen, Inger-Lise, Tryndyak, Volodymyr, White, Alexandra, Woskie, Susan, Fletcher, Tony, Ahmadi, Ayat, Ahmadi, Nahid, Benbrahim-Tallaa, Lamia, Bijoux, Wendy, Chittiboyina, Shirisha, de Conti, Aline, Facchin, Caterina, Madia, Federica, Mattock, Heidi, Merdas, Mira, Pasqual, Elisa, Suonio, Eero, Viegas, Susana, Zupunski, Ljubica, Wedekind, Roland, Schubauer-Berigan, Mary K
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.01.2024
Elsevier Limited
Schlagworte:
Acids
Alkanesulfonic Acids - toxicity
Antigens
Caprylates - toxicity
Carcinogenicity
Carcinogens
Carpets
Cell death
Cell proliferation
Construction materials
DNA methylation
Drinking water
Environmental health
Epigenetics
Fluorocarbons - toxicity
Food packaging
Hematology, Oncology, and Palliative Medicine
Household products
Humans
Kidney cancer
Oxidative stress
Perfluoroalkyl & polyfluoroalkyl substances
Perfluorooctane sulfonic acid
Perfluorooctanoic acid
Testicular cancer
Textiles
Thyroid gland
Trends
Tumors
Working groups
United Kingdom > UK
United States > US
Norway
China
Japan
Denmark
France
ISSN:1470-2045, 1474-5488, 1474-5488
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Applications for fluoropolymers and PFOA include surface coatings for stain, oil, and water resistance on household products, carpets, textiles, and food packaging; personal care products; seals; coatings for cables and wires; and construction materials. Since the previous classification of PFOA (as “possibly carcinogenic to humans”, Group 2B) by the IARC Monographs in 2014,2 many new studies have investigated the association between exposure to PFOA and cancer in experimental animals and humans, as well as mechanistic endpoints relevant to the key characteristics of carcinogens. [...]PFOA induces oxidative stress, modulates receptor-mediated effects (via PPARα, CAR/PXR, and PPARγ), and alters cell proliferation, cell death, and nutrient and energy supply in human primary cells and experimental systems. For testicular cancer, additional evidence was a positive association in an ecological analysis conducted by the Working Group of available data on orchiectomies from the Veneto region of Italy, and a US study finding no associations.9 For all other cancers, the evidence was “inadequate”, as there were only sporadic positive findings.
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Co-senior authors
F Pouzaud, ANSES (France) A Winquist, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention (USA)
A Ahmadi; N Ahmadi; L Benbrahim-Tallaa; W Bijoux; S Chittiboyina; A de Conti; C Facchin; F Madia; H Mattock; M Merdas; E Pasqual; M K Schubauer-Berigan; E Suonio; S Viegas; L Zupunski; R Wedekind
IARC Monographs Working Group Members
Invited Specialists
T Fletcher, London School of Hygiene & Tropical Medicine (UK)
A Amadou, INSERM (France); V Thomas, Sciences Po Lyon (France); D Whu, International Association of Firefighters (USA)
Observers
S Zahm (USA)–Meeting Chair; J P Bonde (Denmark); W A Chiu (USA); J Hoppin (USA); J Kanno (Japan)–Subgroup Meeting Chairs; M Abdallah (UK); C R Blystone (USA); M M Calkins (USA); G H Dong (China); D C Dorman (USA); R Fry (USA); H Guo (China); L S Haug (Norway); J N Hofmann (USA); M Iwasaki (Japan); M Machala (Czech Republic); F R Mancini (France); S S Maria-Engler (Brazil); P Møller (Denmark); J C Ng (Australia); M Pallardy (France); G B Post (USA); S Salihovic (Sweden); J Schlezinger (USA); A Soshilov (USA); K Steenland (USA); I-L Steffensen (Norway); V Tryndyak (USA); A White (USA); S Woskie (USA)
Representatives
IARC Secretariat
ISSN:1470-2045
1474-5488
1474-5488
DOI:10.1016/S1470-2045(23)00622-8