Procalcitonin Test in the Diagnosis of Bacteremia: A Meta-analysis
We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population. We conducted a search of MEDLINE, bibliographies of previous systemic reviews, and pertinent national meeting research abstracts. We included studies...
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| Published in: | Annals of emergency medicine Vol. 50; no. 1; pp. 34 - 41 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
New York, NY
Mosby, Inc
01.07.2007
Elsevier |
| Subjects: | |
| ISSN: | 0196-0644, 1097-6760, 1097-6760 |
| Online Access: | Get full text |
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| Abstract | We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population.
We conducted a search of MEDLINE, bibliographies of previous systemic reviews, and pertinent national meeting research abstracts. We included studies that assessed the diagnostic accuracy of procalcitonin for bacteremia, with blood culture as the reference standard. We included prospective investigations of adults and children with suspected infection studied in the ED or at admission. Two authors independently extracted data and assessed study quality; consensus was reached by conference. The analysis was based on the I2 statistic for heterogeneity, unweighted summary receiver-operating characteristic curve, and random-effects pooled sensitivity and specificity across studies using the same test threshold.
The search yielded 348 publications and 1 unpublished study. Seventeen studies met the inclusion criteria and provided a sample of 2,008 subjects. There was a substantial degree of inconsistency (I2=64%). The unweighted summary receiver-operating characteristic curve provided the best overall estimate of test performance, with an area under the curve of 0.84 (95% confidence interval [CI] 0.75 to 0.90). Sensitivity analysis based on study quality did not significantly change the results. Subgroup analysis including only studies that used a test threshold of 0.5 or 0.4 ng/mL yielded pooled estimates for sensitivity and specificity of 76% (95% CI 0.66 to 0.84) and 70% (95% CI 0.60 to 0.79), respectively.
We found the diagnostic performance of the procalcitonin test for identifying bacteremia in ED patients to be moderate. Future research designed to determine the utility of the procalcitonin test as a diagnostic tool used in isolation for detecting bacteremia in ambulatory patients is needed before widespread clinical use. |
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| AbstractList | Study objective We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population. Methods We conducted a search of MEDLINE, bibliographies of previous systemic reviews, and pertinent national meeting research abstracts. We included studies that assessed the diagnostic accuracy of procalcitonin for bacteremia, with blood culture as the reference standard. We included prospective investigations of adults and children with suspected infection studied in the ED or at admission. Two authors independently extracted data and assessed study quality; consensus was reached by conference. The analysis was based on the beta statistic for heterogeneity, unweighted summary receiver-operating characteristic curve, and random-effects pooled sensitivity and specificity across studies using the same test threshold. Results The search yielded 348 publications and 1 unpublished study. Seventeen studies met the inclusion criteria and provided a sample of 2,008 subjects. There was a substantial degree of inconsistency ( beta =64%). The unweighted summary receiver-operating characteristic curve provided the best overall estimate of test performance, with an area under the curve of 0.84 (95% confidence interval [CI] 0.75 to 0.90). Sensitivity analysis based on study quality did not significantly change the results. Subgroup analysis including only studies that used a test threshold of 0.5 or 0.4 ng/mL yielded pooled estimates for sensitivity and specificity of 76% (95% CI 0.66 to 0.84) and 70% (95% CI 0.60 to 0.79), respectively. Conclusion We found the diagnostic performance of the procalcitonin test for identifying bacteremia in ED patients to be moderate. Future research designed to determine the utility of the procalcitonin test as a diagnostic tool used in isolation for detecting bacteremia in ambulatory patients is needed before widespread clinical use. We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population. We conducted a search of MEDLINE, bibliographies of previous systemic reviews, and pertinent national meeting research abstracts. We included studies that assessed the diagnostic accuracy of procalcitonin for bacteremia, with blood culture as the reference standard. We included prospective investigations of adults and children with suspected infection studied in the ED or at admission. Two authors independently extracted data and assessed study quality; consensus was reached by conference. The analysis was based on the I2 statistic for heterogeneity, unweighted summary receiver-operating characteristic curve, and random-effects pooled sensitivity and specificity across studies using the same test threshold. The search yielded 348 publications and 1 unpublished study. Seventeen studies met the inclusion criteria and provided a sample of 2,008 subjects. There was a substantial degree of inconsistency (I2=64%). The unweighted summary receiver-operating characteristic curve provided the best overall estimate of test performance, with an area under the curve of 0.84 (95% confidence interval [CI] 0.75 to 0.90). Sensitivity analysis based on study quality did not significantly change the results. Subgroup analysis including only studies that used a test threshold of 0.5 or 0.4 ng/mL yielded pooled estimates for sensitivity and specificity of 76% (95% CI 0.66 to 0.84) and 70% (95% CI 0.60 to 0.79), respectively. We found the diagnostic performance of the procalcitonin test for identifying bacteremia in ED patients to be moderate. Future research designed to determine the utility of the procalcitonin test as a diagnostic tool used in isolation for detecting bacteremia in ambulatory patients is needed before widespread clinical use. We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population.STUDY OBJECTIVEWe seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population.We conducted a search of MEDLINE, bibliographies of previous systemic reviews, and pertinent national meeting research abstracts. We included studies that assessed the diagnostic accuracy of procalcitonin for bacteremia, with blood culture as the reference standard. We included prospective investigations of adults and children with suspected infection studied in the ED or at admission. Two authors independently extracted data and assessed study quality; consensus was reached by conference. The analysis was based on the I2 statistic for heterogeneity, unweighted summary receiver-operating characteristic curve, and random-effects pooled sensitivity and specificity across studies using the same test threshold.METHODSWe conducted a search of MEDLINE, bibliographies of previous systemic reviews, and pertinent national meeting research abstracts. We included studies that assessed the diagnostic accuracy of procalcitonin for bacteremia, with blood culture as the reference standard. We included prospective investigations of adults and children with suspected infection studied in the ED or at admission. Two authors independently extracted data and assessed study quality; consensus was reached by conference. The analysis was based on the I2 statistic for heterogeneity, unweighted summary receiver-operating characteristic curve, and random-effects pooled sensitivity and specificity across studies using the same test threshold.The search yielded 348 publications and 1 unpublished study. Seventeen studies met the inclusion criteria and provided a sample of 2,008 subjects. There was a substantial degree of inconsistency (I2=64%). The unweighted summary receiver-operating characteristic curve provided the best overall estimate of test performance, with an area under the curve of 0.84 (95% confidence interval [CI] 0.75 to 0.90). Sensitivity analysis based on study quality did not significantly change the results. Subgroup analysis including only studies that used a test threshold of 0.5 or 0.4 ng/mL yielded pooled estimates for sensitivity and specificity of 76% (95% CI 0.66 to 0.84) and 70% (95% CI 0.60 to 0.79), respectively.RESULTSThe search yielded 348 publications and 1 unpublished study. Seventeen studies met the inclusion criteria and provided a sample of 2,008 subjects. There was a substantial degree of inconsistency (I2=64%). The unweighted summary receiver-operating characteristic curve provided the best overall estimate of test performance, with an area under the curve of 0.84 (95% confidence interval [CI] 0.75 to 0.90). Sensitivity analysis based on study quality did not significantly change the results. Subgroup analysis including only studies that used a test threshold of 0.5 or 0.4 ng/mL yielded pooled estimates for sensitivity and specificity of 76% (95% CI 0.66 to 0.84) and 70% (95% CI 0.60 to 0.79), respectively.We found the diagnostic performance of the procalcitonin test for identifying bacteremia in ED patients to be moderate. Future research designed to determine the utility of the procalcitonin test as a diagnostic tool used in isolation for detecting bacteremia in ambulatory patients is needed before widespread clinical use.CONCLUSIONWe found the diagnostic performance of the procalcitonin test for identifying bacteremia in ED patients to be moderate. Future research designed to determine the utility of the procalcitonin test as a diagnostic tool used in isolation for detecting bacteremia in ambulatory patients is needed before widespread clinical use. Study objectiveWe seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population. MethodsWe conducted a search of MEDLINE, bibliographies of previous systemic reviews, and pertinent national meeting research abstracts. We included studies that assessed the diagnostic accuracy of procalcitonin for bacteremia, with blood culture as the reference standard. We included prospective investigations of adults and children with suspected infection studied in the ED or at admission. Two authors independently extracted data and assessed study quality; consensus was reached by conference. The analysis was based on the I2 statistic for heterogeneity, unweighted summary receiver-operating characteristic curve, and random-effects pooled sensitivity and specificity across studies using the same test threshold. ResultsThe search yielded 348 publications and 1 unpublished study. Seventeen studies met the inclusion criteria and provided a sample of 2,008 subjects. There was a substantial degree of inconsistency ( I2=64%). The unweighted summary receiver-operating characteristic curve provided the best overall estimate of test performance, with an area under the curve of 0.84 (95% confidence interval [CI] 0.75 to 0.90). Sensitivity analysis based on study quality did not significantly change the results. Subgroup analysis including only studies that used a test threshold of 0.5 or 0.4 ng/mL yielded pooled estimates for sensitivity and specificity of 76% (95% CI 0.66 to 0.84) and 70% (95% CI 0.60 to 0.79), respectively. ConclusionWe found the diagnostic performance of the procalcitonin test for identifying bacteremia in ED patients to be moderate. Future research designed to determine the utility of the procalcitonin test as a diagnostic tool used in isolation for detecting bacteremia in ambulatory patients is needed before widespread clinical use. |
| Author | Fiechtl, James F. Jones, Alan E. Kline, Jeffrey A. Ballew, Jason J. Brown, Michael D. |
| Author_xml | – sequence: 1 givenname: Alan E. surname: Jones fullname: Jones, Alan E. email: alan.jones@carolinas.org organization: Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC – sequence: 2 givenname: James F. surname: Fiechtl fullname: Fiechtl, James F. organization: Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC – sequence: 3 givenname: Michael D. surname: Brown fullname: Brown, Michael D. organization: Grand Rapids Medical Education and Research Center/Michigan State University Program in Emergency Medicine, Grand Rapids, MI – sequence: 4 givenname: Jason J. surname: Ballew fullname: Ballew, Jason J. organization: Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC – sequence: 5 givenname: Jeffrey A. surname: Kline fullname: Kline, Jeffrey A. organization: Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC |
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| Cites_doi | 10.1002/sim.1099 10.1053/ajem.2002.33005 10.1097/01.shk.0000186931.02852.5f 10.7326/0003-4819-127-7-199710010-00005 10.1016/S0895-4356(03)00110-0 10.1086/421997 10.1186/1471-2288-3-25 10.1086/341023 10.1016/j.jclinepi.2005.01.006 10.1080/00365540410020217 10.1186/1471-2288-5-20 10.1097/01.CCM.0000143118.41100.14 10.1086/317480 10.1016/0895-4356(94)00099-C 10.1016/S0196-0644(05)80991-6 10.3310/hta9120 10.1016/S0895-4356(00)00188-8 10.7326/0003-4819-142-12_Part_2-200506211-00004 10.1197/j.aem.2003.10.027 10.1016/j.cccn.2003.10.014 10.1136/bmj.327.7414.557 10.1136/ard.62.4.337 10.1016/S0196-0644(99)70422-1 10.1097/01.CCM.0000133017.34137.82 10.1016/0197-2456(86)90046-2 10.1001/jama.1994.03510330081039 10.1007/s10096-003-1066-4 10.1111/j.1469-0691.2004.00883.x 10.1016/j.jclinepi.2005.01.016 10.1001/jama.282.11.1061 10.1007/s004310000681 10.1016/j.jcrc.2004.07.001 10.1007/s10096-004-1191-8 10.1001/jama.291.10.1203 10.1001/archinte.1995.00430060050006 10.1111/j.1742-6723.2004.00561.x 10.1097/00130478-200301000-00004 10.1542/peds.112.5.1054 10.1002/sim.4780121403 10.1016/0140-6736(93)90277-N 10.1046/j.1365-2141.2000.02458.x |
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| Keywords | Infection Intensive care Procalcitonin Bacteriosis Diagnosis Bacteremia Resuscitation |
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| References | Irwig, Macaskill, Glasziou (bib19) 1995; 48 Bugden, Coles, Mills (bib29) 2004; 16 Pantell, Newman, Bernzweig (bib5) 2004; 291 Dinnes, Deeks, Kirby (bib17) 2005; 9 Giamarellou, Giamarellos-Bourboulis, Repoussis (bib30) 2004; 10 Tatsioni, Zarin, Aronson (bib26) 2005; 142 Prat, Dominguez, Rodrigo (bib33) 2004; 23 Meade, Richardson (bib12) 1997; 127 Whiting, Rutjes, Reitsma (bib14) 2003; 3 Fleischhack, Kambeck, Cipic (bib41) 2000; 111 Terrin, Schmid, Lau (bib25) 2005; 58 Vamvakas (bib20) 1998; 122 Han, Doughty, Kofos (bib36) 2003; 4 Ciaccio, Fugardi, Titone (bib32) 2004; 340 Westwood, Whiting, Kleijnen (bib16) 2005; 5 van Langevelde, Joop, van Loon (bib42) 2000; 31 Muller, Becker, Muller (bib3) 2001; 131 Moses, Shapiro, Littenberg (bib18) 1993; 12 Caterino, Scheatzle, Forbes (bib31) 2004; 11 Scott, Grier, Arnold (bib35) 2003; 9 Persson, Engervall, Magnuson (bib28) 2004; 36 Bates, Pruess, Lee (bib9) 1995; 155 Lijmer, Mol, Heisterkamp (bib13) 1999; 282 Deeks, Macaskill, Irwig (bib45) 2005; 58 Mower (bib15) 1999; 33 Higgins, Thompson, Deeks (bib23) 2003; 327 Baraff, Bass, Fleisher (bib6) 1993; 22 Sampson, Barrownman, Moher (bib44) 2003; 56 Jones, Craddock, Tayal (bib8) 2005; 24 Walter (bib21) 2002; 21 Delevaux, Andre, Colombier (bib37) 2003; 62 Giamarellos-Bourboulis, Giannopoulou, Grecka (bib4) 2004; 19 Jaeschke, Guyatt, Sackett (bib46) 1994; 271 Christ-Carin, Muller (bib2) 2005; 135 Deeks, Higgins, Altman (bib22) 2005 Simon, Gauvin, Amre (bib11) 2004; 39 Chirouze, Schuhmacher, Rabaud (bib10) 2002; 35 Aalto, Takala, Kautiainen (bib27) 2004; 23 Galetto-Lacour, Zamora, Gervaix (bib34) 2003; 112 Bochud, Bonten, Marchetti (bib47) 2004; 32 DerSimonian, Laird (bib24) 1986; 7 Chirouze, Schuhmacher, Rabaud (bib38) 2002; 35 Lacour, Gervaix, Zamora (bib40) 2001; 160 Assicot, Gendrel, Carsin (bib1) 1993; 341 Moher, Pham, Klassen (bib43) 2000; 53 Jones, Tayal, Sullivan (bib7) 2004; 32 Guven, Altintop, Baydin (bib39) 2002; 20 Jones (10.1016/j.annemergmed.2006.10.020_bib7) 2004; 32 Westwood (10.1016/j.annemergmed.2006.10.020_bib16) 2005; 5 Lijmer (10.1016/j.annemergmed.2006.10.020_bib13) 1999; 282 Delevaux (10.1016/j.annemergmed.2006.10.020_bib37) 2003; 62 Dinnes (10.1016/j.annemergmed.2006.10.020_bib17) 2005; 9 Fleischhack (10.1016/j.annemergmed.2006.10.020_bib41) 2000; 111 Walter (10.1016/j.annemergmed.2006.10.020_bib21) 2002; 21 Baraff (10.1016/j.annemergmed.2006.10.020_bib6) 1993; 22 Tatsioni (10.1016/j.annemergmed.2006.10.020_bib26) 2005; 142 Caterino (10.1016/j.annemergmed.2006.10.020_bib31) 2004; 11 Mower (10.1016/j.annemergmed.2006.10.020_bib15) 1999; 33 Moher (10.1016/j.annemergmed.2006.10.020_bib43) 2000; 53 Assicot (10.1016/j.annemergmed.2006.10.020_bib1) 1993; 341 Meade (10.1016/j.annemergmed.2006.10.020_bib12) 1997; 127 Jones (10.1016/j.annemergmed.2006.10.020_bib8) 2005; 24 Christ-Carin (10.1016/j.annemergmed.2006.10.020_bib2) 2005; 135 Aalto (10.1016/j.annemergmed.2006.10.020_bib27) 2004; 23 Terrin (10.1016/j.annemergmed.2006.10.020_bib25) 2005; 58 Muller (10.1016/j.annemergmed.2006.10.020_bib3) 2001; 131 Higgins (10.1016/j.annemergmed.2006.10.020_bib23) 2003; 327 Deeks (10.1016/j.annemergmed.2006.10.020_bib22) 2005 Sampson (10.1016/j.annemergmed.2006.10.020_bib44) 2003; 56 Galetto-Lacour (10.1016/j.annemergmed.2006.10.020_bib34) 2003; 112 Chirouze (10.1016/j.annemergmed.2006.10.020_bib38) 2002; 35 Bochud (10.1016/j.annemergmed.2006.10.020_bib47) 2004; 32 Deeks (10.1016/j.annemergmed.2006.10.020_bib45) 2005; 58 Prat (10.1016/j.annemergmed.2006.10.020_bib33) 2004; 23 Giamarellou (10.1016/j.annemergmed.2006.10.020_bib30) 2004; 10 DerSimonian (10.1016/j.annemergmed.2006.10.020_bib24) 1986; 7 Scott (10.1016/j.annemergmed.2006.10.020_bib35) 2003; 9 Ciaccio (10.1016/j.annemergmed.2006.10.020_bib32) 2004; 340 Whiting (10.1016/j.annemergmed.2006.10.020_bib14) 2003; 3 Vamvakas (10.1016/j.annemergmed.2006.10.020_bib20) 1998; 122 van Langevelde (10.1016/j.annemergmed.2006.10.020_bib42) 2000; 31 Chirouze (10.1016/j.annemergmed.2006.10.020_bib10) 2002; 35 Simon (10.1016/j.annemergmed.2006.10.020_bib11) 2004; 39 Guven (10.1016/j.annemergmed.2006.10.020_bib39) 2002; 20 Han (10.1016/j.annemergmed.2006.10.020_bib36) 2003; 4 Irwig (10.1016/j.annemergmed.2006.10.020_bib19) 1995; 48 Jaeschke (10.1016/j.annemergmed.2006.10.020_bib46) 1994; 271 Giamarellos-Bourboulis (10.1016/j.annemergmed.2006.10.020_bib4) 2004; 19 Moses (10.1016/j.annemergmed.2006.10.020_bib18) 1993; 12 Pantell (10.1016/j.annemergmed.2006.10.020_bib5) 2004; 291 Lacour (10.1016/j.annemergmed.2006.10.020_bib40) 2001; 160 Bugden (10.1016/j.annemergmed.2006.10.020_bib29) 2004; 16 Persson (10.1016/j.annemergmed.2006.10.020_bib28) 2004; 36 Bates (10.1016/j.annemergmed.2006.10.020_bib9) 1995; 155 |
| References_xml | – volume: 122 start-page: 675 year: 1998 end-page: 686 ident: bib20 article-title: Meta-analyses of studies of the diagnostic accuracy of laboratory tests: a review of the concepts and methods publication-title: Arch Pathol Lab Med. – volume: 10 start-page: 628 year: 2004 end-page: 633 ident: bib30 article-title: Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study publication-title: Clin Microbiol Infect. – volume: 19 start-page: 152 year: 2004 end-page: 157 ident: bib4 article-title: Should procalcitonin be introduced in the diagnostic criteria for the systemic inflammatory response syndrome and sepsis? publication-title: J Crit Care – volume: 32 start-page: 1703 year: 2004 end-page: 1708 ident: bib7 article-title: Randomized controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients publication-title: Crit Care Med. – volume: 11 start-page: 393 year: 2004 end-page: 396 ident: bib31 article-title: Bacteremic elder emergency department patients: procalcitonin and white count publication-title: Acad Emerg Med. – volume: 39 start-page: 206 year: 2004 end-page: 217 ident: bib11 article-title: Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis publication-title: Clin Infect Dis. – volume: 3 start-page: 25 year: 2003 ident: bib14 article-title: The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews publication-title: BMC Med Res Methodol. – volume: 48 start-page: 119 year: 1995 end-page: 130 ident: bib19 article-title: Meta-analytic methods for diagnostic test accuracy publication-title: J Clin Epidemiol. – volume: 23 start-page: 699 year: 2004 end-page: 704 ident: bib27 article-title: Laboratory markers of systemic inflammation as predictors of bloodstream infection in acutely ill patients admitted to hospital in medical emergency publication-title: Eur J Clin Microbiol Infect Dis. – volume: 16 start-page: 114 year: 2004 end-page: 119 ident: bib29 article-title: The potential role of procalcitonin in the emergency department management of febrile young adults during a sustained meningococcal epidemic publication-title: Emerg Med Australas. – volume: 9 start-page: CR426 year: 2003 end-page: CR431 ident: bib35 article-title: Serum procalcitonin concentration as a negative predictor of serious bacterial infection in acute sickle cell pain crisis publication-title: Med Sci Monit. – volume: 111 start-page: 1093 year: 2000 end-page: 1102 ident: bib41 article-title: Procalcitonin in paediatric cancer patients: its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumor necrosis factor receptor II publication-title: Br J Haematol. – volume: 5 start-page: 20 year: 2005 ident: bib16 article-title: How does study quality affect the results of a diagnostic meta-analysis? publication-title: BMC Med Res Methodol. – volume: 23 start-page: 136 year: 2004 end-page: 138 ident: bib33 article-title: Use of quantitative and semiquantitative procalcitonin measurements to identify children with sepsis and meningitis publication-title: Eur J Clin Microbiol Infect Dis. – volume: 160 start-page: 95 year: 2001 end-page: 100 ident: bib40 article-title: Procalcitonin, IL-6, IL-8, IL-1 receptor antagonist and C-reactive protein as identifiers of serious bacterial infections in children with fever without localizing signs publication-title: Eur J Pediatr. – volume: 32 start-page: S495 year: 2004 end-page: S512 ident: bib47 article-title: Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review publication-title: Crit Care Med. – volume: 155 start-page: 593 year: 1995 end-page: 598 ident: bib9 article-title: How bad are bacteremia and sepsis? publication-title: Arch Intern Med. – volume: 9 start-page: 1 year: 2005 end-page: 113 ident: bib17 article-title: A methodological review of how heterogeneity has been examined in systematic reviews of diagnostic test accuracy publication-title: Health Technol Assess – volume: 142 start-page: 1048 year: 2005 end-page: 1055 ident: bib26 article-title: Challenges in systematic reviews of diagnostic technologies publication-title: Ann Intern Med. – volume: 56 start-page: 943 year: 2003 end-page: 955 ident: bib44 article-title: Should meta-analysis search Embase in addition to MEDLINE? publication-title: J Clin Epidemiol. – volume: 31 start-page: 1343 year: 2000 end-page: 1348 ident: bib42 article-title: Endotoxin, cytokines, and procalcitonin in febrile patients admitted to the hospital: identification of subjects at high risk of mortality publication-title: Clin Infect Dis. – volume: 24 start-page: 513 year: 2005 end-page: 517 ident: bib8 article-title: Diagnostic accuracy of left ventricular function for identifying sepsis among emergency department patients with nontraumatic symptomatic undifferentiated hypotension publication-title: Shock – volume: 58 start-page: 894 year: 2005 end-page: 901 ident: bib25 article-title: In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias publication-title: J Clin Epidemiol. – volume: 53 start-page: 964 year: 2000 end-page: 972 ident: bib43 article-title: What contributions do languages other than English make on the results of meta-analysis? publication-title: J Clin Epidemiol. – volume: 291 start-page: 1203 year: 2004 end-page: 1212 ident: bib5 article-title: Management and outcomes of care of fever in early infancy publication-title: JAMA – volume: 282 start-page: 1061 year: 1999 end-page: 1066 ident: bib13 article-title: Empirical evidence of design-related bias in studies of diagnostic tests publication-title: JAMA – volume: 7 start-page: 177 year: 1986 end-page: 188 ident: bib24 article-title: Meta-analysis in clinical trials publication-title: Control Clin Trials – volume: 341 start-page: 515 year: 1993 end-page: 518 ident: bib1 article-title: High serum procalcitonin concentrations in patients with sepsis and infection publication-title: Lancet – volume: 340 start-page: 149 year: 2004 end-page: 152 ident: bib32 article-title: Procalcitonin levels in plasma in oncohaematologic patients with and without bacterial infections publication-title: Clin Chim Acta. – volume: 271 start-page: 703 year: 1994 end-page: 707 ident: bib46 article-title: Users’ guides to the medical literature, III: how to use an article about a diagnostic test, B: what are the results and will they help me in caring for my patients? publication-title: JAMA – volume: 127 start-page: 531 year: 1997 end-page: 537 ident: bib12 article-title: Selecting and appraising studies for a systematic review publication-title: Ann Intern Med. – volume: 35 start-page: 156 year: 2002 end-page: 161 ident: bib10 article-title: Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever publication-title: Clin Infect Dis. – volume: 327 start-page: 557 year: 2003 end-page: 560 ident: bib23 article-title: Measuring inconsistency in meta-analyses publication-title: BMJ – volume: 20 start-page: 202 year: 2002 end-page: 206 ident: bib39 article-title: Diagnostic value of procalcitonin levels as an early indicator of sepsis publication-title: Am J Emerg Med. – volume: 33 start-page: 85 year: 1999 end-page: 91 ident: bib15 article-title: Evaluating bias and variability in diagnostic test reports publication-title: Ann Emerg Med. – volume: 22 start-page: 1198 year: 1993 end-page: 1210 ident: bib6 article-title: Practice guideline for the management of infants and children 0 to 36 months of age with fever without source: Agency for Health Care Policy and Research publication-title: Ann Emerg Med. – volume: 112 start-page: 1054 year: 2003 end-page: 1060 ident: bib34 article-title: Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center publication-title: Pediatrics – volume: 131 start-page: 595 year: 2001 end-page: 602 ident: bib3 article-title: Procalcitonin: how a hormone became a marker and mediator of sepsis publication-title: Swiss Med Wkly. – volume: 35 start-page: 156 year: 2002 end-page: 161 ident: bib38 article-title: Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever publication-title: Clin Infect Dis. – volume: 58 start-page: 882 year: 2005 end-page: 893 ident: bib45 article-title: The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed publication-title: J Clin Epidemiol. – volume: 21 start-page: 1237 year: 2002 end-page: 1256 ident: bib21 article-title: Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data publication-title: Stat Med. – volume: 4 start-page: 21 year: 2003 end-page: 25 ident: bib36 article-title: Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis publication-title: Pediatr Crit Care Med. – volume: 62 start-page: 337 year: 2003 end-page: 340 ident: bib37 article-title: Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes? publication-title: Ann Rheum Dis. – volume: 135 start-page: 451 year: 2005 end-page: 460 ident: bib2 article-title: Procalcitonin in bacterial infections: hype, hope, more or less? publication-title: Swiss Med Wkly. – start-page: 97 year: 2005 end-page: 166 ident: bib22 article-title: Analyzing and presenting results publication-title: Cochrane Handbook for Systematic Reviews of Interventions – volume: 12 start-page: 1293 year: 1993 end-page: 1316 ident: bib18 article-title: Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations publication-title: Stat Med. – volume: 36 start-page: 365 year: 2004 end-page: 371 ident: bib28 article-title: Use of inflammatory markers for early detection of bacteraemia in patients with febrile neutropenia publication-title: Scand J Infect Dis. – volume: 21 start-page: 1237 year: 2002 ident: 10.1016/j.annemergmed.2006.10.020_bib21 article-title: Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data publication-title: Stat Med. doi: 10.1002/sim.1099 – volume: 20 start-page: 202 year: 2002 ident: 10.1016/j.annemergmed.2006.10.020_bib39 article-title: Diagnostic value of procalcitonin levels as an early indicator of sepsis publication-title: Am J Emerg Med. doi: 10.1053/ajem.2002.33005 – volume: 24 start-page: 513 year: 2005 ident: 10.1016/j.annemergmed.2006.10.020_bib8 article-title: Diagnostic accuracy of left ventricular function for identifying sepsis among emergency department patients with nontraumatic symptomatic undifferentiated hypotension publication-title: Shock doi: 10.1097/01.shk.0000186931.02852.5f – volume: 127 start-page: 531 year: 1997 ident: 10.1016/j.annemergmed.2006.10.020_bib12 article-title: Selecting and appraising studies for a systematic review publication-title: Ann Intern Med. doi: 10.7326/0003-4819-127-7-199710010-00005 – volume: 56 start-page: 943 year: 2003 ident: 10.1016/j.annemergmed.2006.10.020_bib44 article-title: Should meta-analysis search Embase in addition to MEDLINE? publication-title: J Clin Epidemiol. doi: 10.1016/S0895-4356(03)00110-0 – volume: 39 start-page: 206 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib11 article-title: Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis publication-title: Clin Infect Dis. doi: 10.1086/421997 – volume: 3 start-page: 25 year: 2003 ident: 10.1016/j.annemergmed.2006.10.020_bib14 article-title: The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews publication-title: BMC Med Res Methodol. doi: 10.1186/1471-2288-3-25 – volume: 35 start-page: 156 year: 2002 ident: 10.1016/j.annemergmed.2006.10.020_bib38 article-title: Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever publication-title: Clin Infect Dis. doi: 10.1086/341023 – volume: 58 start-page: 894 year: 2005 ident: 10.1016/j.annemergmed.2006.10.020_bib25 article-title: In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias publication-title: J Clin Epidemiol. doi: 10.1016/j.jclinepi.2005.01.006 – volume: 36 start-page: 365 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib28 article-title: Use of inflammatory markers for early detection of bacteraemia in patients with febrile neutropenia publication-title: Scand J Infect Dis. doi: 10.1080/00365540410020217 – volume: 5 start-page: 20 year: 2005 ident: 10.1016/j.annemergmed.2006.10.020_bib16 article-title: How does study quality affect the results of a diagnostic meta-analysis? publication-title: BMC Med Res Methodol. doi: 10.1186/1471-2288-5-20 – volume: 32 start-page: S495 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib47 article-title: Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review publication-title: Crit Care Med. doi: 10.1097/01.CCM.0000143118.41100.14 – volume: 31 start-page: 1343 year: 2000 ident: 10.1016/j.annemergmed.2006.10.020_bib42 article-title: Endotoxin, cytokines, and procalcitonin in febrile patients admitted to the hospital: identification of subjects at high risk of mortality publication-title: Clin Infect Dis. doi: 10.1086/317480 – volume: 48 start-page: 119 year: 1995 ident: 10.1016/j.annemergmed.2006.10.020_bib19 article-title: Meta-analytic methods for diagnostic test accuracy publication-title: J Clin Epidemiol. doi: 10.1016/0895-4356(94)00099-C – volume: 22 start-page: 1198 year: 1993 ident: 10.1016/j.annemergmed.2006.10.020_bib6 article-title: Practice guideline for the management of infants and children 0 to 36 months of age with fever without source: Agency for Health Care Policy and Research publication-title: Ann Emerg Med. doi: 10.1016/S0196-0644(05)80991-6 – volume: 9 start-page: 1 year: 2005 ident: 10.1016/j.annemergmed.2006.10.020_bib17 article-title: A methodological review of how heterogeneity has been examined in systematic reviews of diagnostic test accuracy publication-title: Health Technol Assess doi: 10.3310/hta9120 – volume: 53 start-page: 964 year: 2000 ident: 10.1016/j.annemergmed.2006.10.020_bib43 article-title: What contributions do languages other than English make on the results of meta-analysis? publication-title: J Clin Epidemiol. doi: 10.1016/S0895-4356(00)00188-8 – volume: 142 start-page: 1048 year: 2005 ident: 10.1016/j.annemergmed.2006.10.020_bib26 article-title: Challenges in systematic reviews of diagnostic technologies publication-title: Ann Intern Med. doi: 10.7326/0003-4819-142-12_Part_2-200506211-00004 – volume: 11 start-page: 393 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib31 article-title: Bacteremic elder emergency department patients: procalcitonin and white count publication-title: Acad Emerg Med. doi: 10.1197/j.aem.2003.10.027 – volume: 340 start-page: 149 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib32 article-title: Procalcitonin levels in plasma in oncohaematologic patients with and without bacterial infections publication-title: Clin Chim Acta. doi: 10.1016/j.cccn.2003.10.014 – volume: 327 start-page: 557 year: 2003 ident: 10.1016/j.annemergmed.2006.10.020_bib23 article-title: Measuring inconsistency in meta-analyses publication-title: BMJ doi: 10.1136/bmj.327.7414.557 – volume: 62 start-page: 337 year: 2003 ident: 10.1016/j.annemergmed.2006.10.020_bib37 article-title: Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes? publication-title: Ann Rheum Dis. doi: 10.1136/ard.62.4.337 – volume: 33 start-page: 85 year: 1999 ident: 10.1016/j.annemergmed.2006.10.020_bib15 article-title: Evaluating bias and variability in diagnostic test reports publication-title: Ann Emerg Med. doi: 10.1016/S0196-0644(99)70422-1 – volume: 32 start-page: 1703 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib7 article-title: Randomized controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients publication-title: Crit Care Med. doi: 10.1097/01.CCM.0000133017.34137.82 – volume: 7 start-page: 177 year: 1986 ident: 10.1016/j.annemergmed.2006.10.020_bib24 article-title: Meta-analysis in clinical trials publication-title: Control Clin Trials doi: 10.1016/0197-2456(86)90046-2 – volume: 271 start-page: 703 year: 1994 ident: 10.1016/j.annemergmed.2006.10.020_bib46 article-title: Users’ guides to the medical literature, III: how to use an article about a diagnostic test, B: what are the results and will they help me in caring for my patients? publication-title: JAMA doi: 10.1001/jama.1994.03510330081039 – volume: 23 start-page: 136 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib33 article-title: Use of quantitative and semiquantitative procalcitonin measurements to identify children with sepsis and meningitis publication-title: Eur J Clin Microbiol Infect Dis. doi: 10.1007/s10096-003-1066-4 – volume: 131 start-page: 595 year: 2001 ident: 10.1016/j.annemergmed.2006.10.020_bib3 article-title: Procalcitonin: how a hormone became a marker and mediator of sepsis publication-title: Swiss Med Wkly. – volume: 9 start-page: CR426 year: 2003 ident: 10.1016/j.annemergmed.2006.10.020_bib35 article-title: Serum procalcitonin concentration as a negative predictor of serious bacterial infection in acute sickle cell pain crisis publication-title: Med Sci Monit. – volume: 10 start-page: 628 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib30 article-title: Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study publication-title: Clin Microbiol Infect. doi: 10.1111/j.1469-0691.2004.00883.x – volume: 58 start-page: 882 year: 2005 ident: 10.1016/j.annemergmed.2006.10.020_bib45 article-title: The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed publication-title: J Clin Epidemiol. doi: 10.1016/j.jclinepi.2005.01.016 – volume: 122 start-page: 675 year: 1998 ident: 10.1016/j.annemergmed.2006.10.020_bib20 article-title: Meta-analyses of studies of the diagnostic accuracy of laboratory tests: a review of the concepts and methods publication-title: Arch Pathol Lab Med. – volume: 135 start-page: 451 year: 2005 ident: 10.1016/j.annemergmed.2006.10.020_bib2 article-title: Procalcitonin in bacterial infections: hype, hope, more or less? publication-title: Swiss Med Wkly. – volume: 282 start-page: 1061 year: 1999 ident: 10.1016/j.annemergmed.2006.10.020_bib13 article-title: Empirical evidence of design-related bias in studies of diagnostic tests publication-title: JAMA doi: 10.1001/jama.282.11.1061 – volume: 160 start-page: 95 year: 2001 ident: 10.1016/j.annemergmed.2006.10.020_bib40 article-title: Procalcitonin, IL-6, IL-8, IL-1 receptor antagonist and C-reactive protein as identifiers of serious bacterial infections in children with fever without localizing signs publication-title: Eur J Pediatr. doi: 10.1007/s004310000681 – volume: 19 start-page: 152 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib4 article-title: Should procalcitonin be introduced in the diagnostic criteria for the systemic inflammatory response syndrome and sepsis? publication-title: J Crit Care doi: 10.1016/j.jcrc.2004.07.001 – volume: 23 start-page: 699 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib27 article-title: Laboratory markers of systemic inflammation as predictors of bloodstream infection in acutely ill patients admitted to hospital in medical emergency publication-title: Eur J Clin Microbiol Infect Dis. doi: 10.1007/s10096-004-1191-8 – volume: 291 start-page: 1203 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib5 article-title: Management and outcomes of care of fever in early infancy publication-title: JAMA doi: 10.1001/jama.291.10.1203 – volume: 35 start-page: 156 year: 2002 ident: 10.1016/j.annemergmed.2006.10.020_bib10 article-title: Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever publication-title: Clin Infect Dis. doi: 10.1086/341023 – volume: 155 start-page: 593 year: 1995 ident: 10.1016/j.annemergmed.2006.10.020_bib9 article-title: How bad are bacteremia and sepsis? publication-title: Arch Intern Med. doi: 10.1001/archinte.1995.00430060050006 – volume: 16 start-page: 114 year: 2004 ident: 10.1016/j.annemergmed.2006.10.020_bib29 article-title: The potential role of procalcitonin in the emergency department management of febrile young adults during a sustained meningococcal epidemic publication-title: Emerg Med Australas. doi: 10.1111/j.1742-6723.2004.00561.x – volume: 4 start-page: 21 year: 2003 ident: 10.1016/j.annemergmed.2006.10.020_bib36 article-title: Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis publication-title: Pediatr Crit Care Med. doi: 10.1097/00130478-200301000-00004 – volume: 112 start-page: 1054 year: 2003 ident: 10.1016/j.annemergmed.2006.10.020_bib34 article-title: Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center publication-title: Pediatrics doi: 10.1542/peds.112.5.1054 – volume: 12 start-page: 1293 year: 1993 ident: 10.1016/j.annemergmed.2006.10.020_bib18 article-title: Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations publication-title: Stat Med. doi: 10.1002/sim.4780121403 – start-page: 97 year: 2005 ident: 10.1016/j.annemergmed.2006.10.020_bib22 article-title: Analyzing and presenting results – volume: 341 start-page: 515 year: 1993 ident: 10.1016/j.annemergmed.2006.10.020_bib1 article-title: High serum procalcitonin concentrations in patients with sepsis and infection publication-title: Lancet doi: 10.1016/0140-6736(93)90277-N – volume: 111 start-page: 1093 year: 2000 ident: 10.1016/j.annemergmed.2006.10.020_bib41 article-title: Procalcitonin in paediatric cancer patients: its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumor necrosis factor receptor II publication-title: Br J Haematol. doi: 10.1046/j.1365-2141.2000.02458.x |
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We... Study objectiveWe seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED)... Study objective We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED)... We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population.STUDY... |
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| SubjectTerms | Adult Age Factors Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacteremia - blood Bacteremia - epidemiology Bacterial diseases Bacterial diseases of the genital system Biological and medical sciences Calcitonin - blood Calcitonin Gene-Related Peptide Child Emergency Emergency and intensive care: infection, septic shock Emergency Medicine - methods Emergency Medicine - statistics & numerical data Human bacterial diseases Humans Infectious diseases Intensive care medicine Medical sciences Odds Ratio Prevalence Protein Precursors - blood Sensitivity and Specificity |
| Title | Procalcitonin Test in the Diagnosis of Bacteremia: A Meta-analysis |
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