Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study

In neonatal encephalopathy, the clinical manifestations of injury can only be reliably assessed several years after an intervention, complicating early prognostication and rendering trials of promising neuroprotectants slow and expensive. We aimed to determine the accuracy of thalamic proton magneti...

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Bibliographic Details
Published in:	Lancet neurology Vol. 18; no. 1; pp. 35 - 45
Main Authors:	Lally, Peter J, Montaldo, Paolo, Oliveira, Vânia, Soe, Aung, Swamy, Ravi, Bassett, Paul, Mendoza, Josephine, Atreja, Gaurav, Kariholu, Ujwal, Pattnayak, Santosh, Sashikumar, Palaniappan, Harizaj, Helen, Mitchell, Martin, Ganesh, Vijayakumar, Harigopal, Sundeep, Dixon, Jennifer, English, Philip, Clarke, Paul, Muthukumar, Priya, Satodia, Prakash, Wayte, Sarah, Abernethy, Laurence J, Yajamanyam, Kiran, Bainbridge, Alan, Price, David, Huertas, Angela, Sharp, David J, Kalra, Vaneet, Chawla, Sanjay, Shankaran, Seetha, Thayyil, Sudhin, Harigopal, Sundeeep
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.01.2019 Elsevier Limited Lancet Pub. Group
Subjects:	Accuracy Anisotropy Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Basal ganglia Biomarkers Brain - diagnostic imaging Brain - metabolism Brain injury Brain research Choline Clinical trials Cohort analysis Congenital defects Cortex Creatine EEG Encephalopathy Female Humans Hypothermia Hypothermia, Induced Hypoxia-Ischemia, Brain - diagnostic imaging Hypoxia-Ischemia, Brain - metabolism Hypoxia-Ischemia, Brain - therapy Infant Infant, Newborn Infants Intensive care units Lactic acid Magnetic resonance imaging Magnetic Resonance Spectroscopy Male N-Acetylaspartate Neonates Neurodevelopmental disorders Neuroprotection Newborn babies NMR Nuclear magnetic resonance Prospective Studies Protons Scanners Software Spectrum analysis Thalamus Traumatic brain injury Treatment Outcome United Kingdom > UK United States > US
ISSN:	1474-4422, 1474-4465, 1474-4465
Online Access:	Get full text
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