Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Joint modeling of a number of phenotypes using multivariate methods has often been neglected in genome-wide association studies and if used, replication has not been sought. Modern omics technologies allow characterization of functional phenomena using a large number of related phenotype measures, w...

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Bibliographic Details
Published in:	Nature communications Vol. 8; no. 1; pp. 447 - 10
Main Authors:	Shen, Xia, Klarić, Lucija, Sharapov, Sodbo, Mangino, Massimo, Ning, Zheng, Wu, Di, Trbojević-Akmačić, Irena, Pučić-Baković, Maja, Rudan, Igor, Polašek, Ozren, Hayward, Caroline, Spector, Timothy D., Wilson, James F., Lauc, Gordan, Aulchenko, Yurii S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.09.2017 Nature Publishing Group Nature Portfolio
Subjects:	631/114/2163 631/208/205/2138 Adolescent Adult Aged Aged, 80 and over B-Lymphocytes - metabolism Cell Cycle Proteins - genetics Cohort Studies Cytoskeletal Proteins Female Fucosyltransferases - genetics Genetic Loci Genetic Pleiotropy Genome-wide association studies Genome-Wide Association Study Glycosylation Humanities and Social Sciences Humans Immune system Immunoglobulin G Immunoglobulin G - genetics Immunoglobulin G - metabolism Loci Lymphocytes Male Microtubule Proteins - genetics Middle Aged multidisciplinary Multivariate analysis Phenotype Science Science (multidisciplinary) Transcriptional Elongation Factors - genetics United Kingdom Young Adult United Kingdom
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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