N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscri...

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Bibliographic Details
Published in:	Journal of hematology and oncology Vol. 14; no. 1; pp. 1 - 19
Main Authors:	Huang, Wei, Chen, Tian-Qi, Fang, Ke, Zeng, Zhan-Cheng, Ye, Hua, Chen, Yue-Qin
Format:	Journal Article
Language:	English
Published:	London BioMed Central 27.07.2021 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Biology Cancer Cancer Research Chemotherapy Drug discovery Epigenetics Gene expression Genes Genetic aspects Genomes Hematology Immunotherapy m6A m6A methyltransferase Medicine Medicine & Public Health Methyltransferase Methyltransferases MicroRNAs N6-methyladenosine Oncology Post-transcription Proteins Radiation therapy Review RNA polymerase Roles Therapy resistance Transcriptomes Tumorigenesis m6A Therapy resistance Drug discovery m6A methyltransferase Cancer
ISSN:	1756-8722, 1756-8722
Online Access:	Get full text
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