N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscri...

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Vydáno v:Journal of hematology and oncology Ročník 14; číslo 1; s. 1 - 19
Hlavní autoři: Huang, Wei, Chen, Tian-Qi, Fang, Ke, Zeng, Zhan-Cheng, Ye, Hua, Chen, Yue-Qin
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 27.07.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Biology
Cancer
Cancer Research
Chemotherapy
Drug discovery
Epigenetics
Gene expression
Genes
Genetic aspects
Genomes
Hematology
Immunotherapy
m6A
m6A methyltransferase
Medicine
Medicine & Public Health
Methyltransferase
Methyltransferases
MicroRNAs
N6-methyladenosine
Oncology
Post-transcription
Proteins
Radiation therapy
Review
RNA polymerase
Roles
Therapy resistance
Transcriptomes
Tumorigenesis
m6A
Therapy resistance
Drug discovery
m6A methyltransferase
Cancer
ISSN:1756-8722, 1756-8722
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Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscriptional regulation. To date, m6A methyltransferases have been reported to execute m6A deposition on distinct RNAs by their own or forming different complexes with additional partner proteins. In this review, we summarize the function of these m6A methyltransferases or complexes in regulating the key genes and pathways of cancer biology. We also highlight the progress in the use of m6A methyltransferases in mediating therapy resistance, including chemotherapy, targeted therapy, immunotherapy and radiotherapy. Finally, we discuss the current approaches and clinical potential of m6A methyltransferase-targeting strategies.
AbstractList Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscriptional regulation. To date, m6A methyltransferases have been reported to execute m6A deposition on distinct RNAs by their own or forming different complexes with additional partner proteins. In this review, we summarize the function of these m6A methyltransferases or complexes in regulating the key genes and pathways of cancer biology. We also highlight the progress in the use of m6A methyltransferases in mediating therapy resistance, including chemotherapy, targeted therapy, immunotherapy and radiotherapy. Finally, we discuss the current approaches and clinical potential of m6A methyltransferase-targeting strategies.
N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscriptional regulation. To date, m6A methyltransferases have been reported to execute m6A deposition on distinct RNAs by their own or forming different complexes with additional partner proteins. In this review, we summarize the function of these m6A methyltransferases or complexes in regulating the key genes and pathways of cancer biology. We also highlight the progress in the use of m6A methyltransferases in mediating therapy resistance, including chemotherapy, targeted therapy, immunotherapy and radiotherapy. Finally, we discuss the current approaches and clinical potential of m6A methyltransferase-targeting strategies.
N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscriptional regulation. To date, m6A methyltransferases have been reported to execute m6A deposition on distinct RNAs by their own or forming different complexes with additional partner proteins. In this review, we summarize the function of these m6A methyltransferases or complexes in regulating the key genes and pathways of cancer biology. We also highlight the progress in the use of m6A methyltransferases in mediating therapy resistance, including chemotherapy, targeted therapy, immunotherapy and radiotherapy. Finally, we discuss the current approaches and clinical potential of m6A methyltransferase-targeting strategies. Keywords: m6A, m6A methyltransferase, Cancer, Therapy resistance, Drug discovery
N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscriptional regulation. To date, m6A methyltransferases have been reported to execute m6A deposition on distinct RNAs by their own or forming different complexes with additional partner proteins. In this review, we summarize the function of these m6A methyltransferases or complexes in regulating the key genes and pathways of cancer biology. We also highlight the progress in the use of m6A methyltransferases in mediating therapy resistance, including chemotherapy, targeted therapy, immunotherapy and radiotherapy. Finally, we discuss the current approaches and clinical potential of m6A methyltransferase-targeting strategies.N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscriptional regulation. To date, m6A methyltransferases have been reported to execute m6A deposition on distinct RNAs by their own or forming different complexes with additional partner proteins. In this review, we summarize the function of these m6A methyltransferases or complexes in regulating the key genes and pathways of cancer biology. We also highlight the progress in the use of m6A methyltransferases in mediating therapy resistance, including chemotherapy, targeted therapy, immunotherapy and radiotherapy. Finally, we discuss the current approaches and clinical potential of m6A methyltransferase-targeting strategies.
ArticleNumber 117
Audience Academic
Author Chen, Tian-Qi
Fang, Ke
Zeng, Zhan-Cheng
Ye, Hua
Chen, Yue-Qin
Huang, Wei
Author_xml – sequence: 1
  givenname: Wei
  surname: Huang
  fullname: Huang, Wei
  organization: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University
– sequence: 2
  givenname: Tian-Qi
  surname: Chen
  fullname: Chen, Tian-Qi
  organization: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University
– sequence: 3
  givenname: Ke
  surname: Fang
  fullname: Fang, Ke
  organization: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University
– sequence: 4
  givenname: Zhan-Cheng
  surname: Zeng
  fullname: Zeng, Zhan-Cheng
  organization: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University
– sequence: 5
  givenname: Hua
  surname: Ye
  fullname: Ye, Hua
  organization: Department of Hepatobiliary, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
– sequence: 6
  givenname: Yue-Qin
  orcidid: 0000-0002-5140-1993
  surname: Chen
  fullname: Chen, Yue-Qin
  email: lsscyq@mail.sysu.edu.cn
  organization: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University
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Issue 1
Keywords m6A
Therapy resistance
Drug discovery
m6A methyltransferase
Cancer
Language English
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Snippet N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs....
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and...
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SubjectTerms Biology
Cancer
Cancer Research
Chemotherapy
Drug discovery
Epigenetics
Gene expression
Genes
Genetic aspects
Genomes
Hematology
Immunotherapy
m6A
m6A methyltransferase
Medicine
Medicine & Public Health
Methyltransferase
Methyltransferases
MicroRNAs
N6-methyladenosine
Oncology
Post-transcription
Proteins
Radiation therapy
Review
RNA polymerase
Roles
Therapy resistance
Transcriptomes
Tumorigenesis
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Title N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
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