First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy

Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied the possible association between PFASs and fetal biometry. In 1230 mother–child pairs of...

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Published in:Environment international Vol. 130; p. 104830
Main Authors: Costa, Olga, Iñiguez, Carmen, Manzano-Salgado, Cyntia B., Amiano, Pilar, Murcia, Mario, Casas, Maribel, Irizar, Amaia, Basterrechea, Mikel, Beneito, Andrea, Schettgen, Thomas, Sunyer, Jordi, Vrijheid, Martine, Ballester, Ferran, Lopez-Espinosa, Maria-Jose
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.09.2019
Elsevier
Subjects:
Adult
anthropometric measurements
Cohort Studies
Female
femur
Fetal Development
Fetal growth
Fetus
Fluorine Compounds - analysis
Humans
Male
maternal exposure
meta-analysis
perfluorohexane sulfonic acid
perfluorononanoic acid
perfluorooctane sulfonic acid
perfluorooctanoic acid
PFASs
PFHxS
PFNA
PFOA
PFOS
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, First
regression analysis
smoking (habit)
ultrasonics
Fetal growth
PCBs
df
PFASs
FL
PFNA
NO2
P
SD
EFW
AIC
INMA
BMI
Hg
eGFR
AC
OR
PFHxS
CI
HCB
PBDEs
DAG
SGA
PFOA
LMP
LOQ
GAM
Ref
BPD
PFOS
ISSN:0160-4120, 1873-6750, 1873-6750
Online Access:Get full text
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Summary:Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied the possible association between PFASs and fetal biometry. In 1230 mother–child pairs of three cohorts from the Spanish INMA-Project, we analyzed perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in first-trimester maternal plasma (collection: 2003–2008). We measured abdominal circumference (AC), femur length (FL), biparietal diameter (BPD), and estimated fetal weight (EFW) by ultrasounds at 12, 20, and 34 gestational weeks. We conducted multivariable linear regression analyses between log2-transformed (PFASs) and SD-scores of fetal parameters in each cohort and subsequent meta-analysis. We also assessed effect modification by sex and maternal smoking. PFHxS, PFOA, PFOS, and PFNA medians were: 0.58, 2.35, 6.05, and 0.65 ng/mL, respectively. There were no associations for the whole population in any trimester of pregnancy. However, we found an indication that maternal smoking modified the effect in different directions depending on the PFAS. Among smokers (31%), we found negative associations between both PFOA and PFNA and FL or EFW at week 20 (% change ranging between −6.8% and −5.7% per twofold PFAS increase) and positive associations between PFHxS or PFOS and BPD at week 34 (6.8% and 6.3%, respectively). Results did not suggest an overall association between prenatal PFASs and fetal growth. The results among smokers should be taken with caution and further studies are warranted to elucidate the possible role of smoking in this association. •First study on maternal PFASs and fetal growth assessed longitudinally by ultrasounds•No evidence of an association between prenatal PFAS exposure and fetal growth•However, there was effect modification by maternal smoking during pregnancy.•Associations were only found among smokers with different directions depending on the PFAS.
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ISSN:0160-4120
1873-6750
1873-6750
DOI:10.1016/j.envint.2019.05.024