The genetic architecture of Parkinson's disease

Parkinson's disease is a complex neurodegenerative disorder for which both rare and common genetic variants contribute to disease risk, onset, and progression. Mutations in more than 20 genes have been associated with the disease, most of which are highly penetrant and often cause early onset o...

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Veröffentlicht in:	Lancet neurology Jg. 19; H. 2; S. 170 - 178
Hauptverfasser:	Blauwendraat, Cornelis, Nalls, Mike A, Singleton, Andrew B
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.02.2020 Elsevier Limited
Schlagworte:	Alleles Dementia - genetics Deoxyribonucleic acid Disease Progression DNA Genes Genetic diversity Genetic Predisposition to Disease - genetics Genetic variability Genetics Genome-wide association studies Genome-Wide Association Study Genomes Humans Kinases Learning algorithms Movement disorders Mutation Mutation - genetics Neurodegenerative diseases Neurodegenerative Diseases - diagnosis Neurodegenerative Diseases - genetics Parkinson Disease - diagnosis Parkinson Disease - genetics Parkinson's disease Ribonucleic acid Risk Factors RNA
ISSN:	1474-4422, 1474-4465, 1474-4465
Online-Zugang:	Volltext
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