Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans

Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides . We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human...

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Bibliographic Details
Published in:	eLife Vol. 9
Main Authors:	Easton, Alice, Gao, Shenghan, Lawton, Scott P, Bennuru, Sasisekhar, Khan, Asis, Dahlstrom, Eric, Oliveira, Rita G, Kepha, Stella, Porcella, Stephen F, Webster, Joanne, Anderson, Roy, Grigg, Michael E, Davis, Richard E, Wang, Jianbin, Nutman, Thomas B
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 06.11.2020 eLife Sciences Publications, Ltd eLife Sciences Publications Ltd
Subjects:	Analysis Animals Ascariasis - parasitology Ascariasis - veterinary Ascaris lumbricoides Ascaris lumbricoides - genetics Ascaris lumbricoides - pathogenicity Ascaris suum Ascaris suum - genetics Ascaris suum - pathogenicity Cyclooxygenase 1 - genetics Epidemiology and Global Health Female Genes Genetics and Genomics Genome, Helminth - genetics Genome, Mitochondrial - genetics Genomes Genomics Heterozygote Humans Hybridization, Genetic - genetics Kenya Male Phylogenetics Phylogeny Polymorphism, Single Nucleotide - genetics Proteome - genetics reference genome Roundworms species complex Swine Swine Diseases - parasitology zoonoses Kenya global health Ascaris lumbricoides epidemiology genetics species complex Ascaris suum Phylogenetics genomics reference genome zoonoses human
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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