Guards of the great wall: bacterial lysozyme inhibitors

Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if not all, animals produce lysozymes as key effectors of their innate immune system. Recently, highly sp...

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Podrobná bibliografia
Vydané v:	Trends in microbiology (Regular ed.) Ročník 20; číslo 10; s. 501 - 510
Hlavní autori:	Callewaert, Lien, Van Herreweghe, Joris M., Vanderkelen, Lise, Leysen, Seppe, Voet, Arnout, Michiels, Chris W.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Ltd 01.10.2012
Predmet:	Animals autolysin inhibition Bacteria Bacteria - enzymology Bacteria - metabolism bacterial lysozyme inhibitors Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism bacteria–host interaction cell walls Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Humans innate immunity Internal Medicine lysozyme Models, Biological Models, Molecular Muramidase - antagonists & inhibitors peptidoglycan peptidoglycans Phylogeny Sequence Homology turgor peptidoglycan autolysin inhibition bacterial lysozyme inhibitors bacteria–host interaction
ISSN:	0966-842X, 1878-4380, 1878-4380
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Popis
Shrnutí:	Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if not all, animals produce lysozymes as key effectors of their innate immune system. Recently, highly specific bacterial proteinaceous lysozyme inhibitors against the three major animal lysozyme families have been discovered in bacteria, and these may represent a bacterial answer to animal lysozymes. Here, we will review their properties and phylogenetic distribution, present their structure and molecular interaction mechanism with lysozyme, and discuss their possible biological functions and potential applications.
Bibliografia:	http://dx.doi.org/10.1016/j.tim.2012.06.005 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0966-842X 1878-4380 1878-4380
DOI:	10.1016/j.tim.2012.06.005