Guards of the great wall: bacterial lysozyme inhibitors

Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if not all, animals produce lysozymes as key effectors of their innate immune system. Recently, highly sp...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) Vol. 20; no. 10; pp. 501 - 510
Main Authors: Callewaert, Lien, Van Herreweghe, Joris M., Vanderkelen, Lise, Leysen, Seppe, Voet, Arnout, Michiels, Chris W.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.10.2012
Subjects:
Animals
autolysin inhibition
Bacteria
Bacteria - enzymology
Bacteria - metabolism
bacterial lysozyme inhibitors
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
bacteria–host interaction
cell walls
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - metabolism
Humans
innate immunity
Internal Medicine
lysozyme
Models, Biological
Models, Molecular
Muramidase - antagonists & inhibitors
peptidoglycan
peptidoglycans
Phylogeny
Sequence Homology
turgor
peptidoglycan
autolysin inhibition
bacterial lysozyme inhibitors
bacteria–host interaction
ISSN:0966-842X, 1878-4380, 1878-4380
Online Access:Get full text
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Summary:Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if not all, animals produce lysozymes as key effectors of their innate immune system. Recently, highly specific bacterial proteinaceous lysozyme inhibitors against the three major animal lysozyme families have been discovered in bacteria, and these may represent a bacterial answer to animal lysozymes. Here, we will review their properties and phylogenetic distribution, present their structure and molecular interaction mechanism with lysozyme, and discuss their possible biological functions and potential applications.
Bibliography:http://dx.doi.org/10.1016/j.tim.2012.06.005
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ISSN:0966-842X
1878-4380
1878-4380
DOI:10.1016/j.tim.2012.06.005