Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex

The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-relat...

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Bibliographic Details
Published in:	PloS one Vol. 18; no. 11; p. e0293673
Main Authors:	van Leeuwen, Anoek L. I., Beijer, Elise, Ibelings, Roselique, Dekker, Nicole A. M., van der Steen, Marjolein R. A., Roelofs, Joris J. T. H., van Meurs, Matijs, Molema, Grietje, van den Brom, Charissa E.
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 16.11.2023 Public Library of Science (PLoS)
Subjects:	Angiopoietin Animals Circulation Deletion Demographic aspects Diagnosis Dropsy Dry weight Edema Endothelium Enzyme-linked immunosorbent assay Estrogen Estrogen receptors Estrogens Ethylenediaminetetraacetic acid Experiments Females Gender differences Gene expression Genes Hemorrhagic shock Kidneys Kinases Lungs Males Neutrophils Permeability Phosphatase Phosphorylation Proteins R&D Renal agenesis Research & development Risk factors RNA Sex differences Sexual dimorphism Vascular endothelial growth factor Weight Netherlands Minneapolis Minnesota United States > US
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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