Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex

The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-relat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one Jg. 18; H. 11; S. e0293673
Hauptverfasser:	van Leeuwen, Anoek L. I., Beijer, Elise, Ibelings, Roselique, Dekker, Nicole A. M., van der Steen, Marjolein R. A., Roelofs, Joris J. T. H., van Meurs, Matijs, Molema, Grietje, van den Brom, Charissa E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	San Francisco Public Library of Science 16.11.2023 Public Library of Science (PLoS)
Schlagworte:	Angiopoietin Animals Circulation Deletion Demographic aspects Diagnosis Dropsy Dry weight Edema Endothelium Enzyme-linked immunosorbent assay Estrogen Estrogen receptors Estrogens Ethylenediaminetetraacetic acid Experiments Females Gender differences Gene expression Genes Hemorrhagic shock Kidneys Kinases Lungs Males Neutrophils Permeability Phosphatase Phosphorylation Proteins R&D Renal agenesis Research & development Risk factors RNA Sex differences Sexual dimorphism Vascular endothelial growth factor Weight Netherlands Minneapolis Minnesota United States > US
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation. Adult male and female heterozygous Tie2 knockout mice (Tie2.sup.+/-) and wild-type controls (Tie2.sup.+/+) were included (n = 9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR. In Tie2.sup.+/+ mice, females had higher circulating angiopoietin-2 (138%, p<0.05) compared to males. Gene expression of angiopoietin-1 (204%, p<0.01), angiopoietin-2 (542%, p<0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in both organs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2.sup.+/+ females and males. Tie2.sup.+/+ females had lower circulating NGAL (41%, p<0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected. Female sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system.
AbstractList	Background The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation. Methods Adult male and female heterozygous Tie2 knockout mice (Tie2.sup.+/-) and wild-type controls (Tie2.sup.+/+) were included (n = 9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR. Results In Tie2.sup.+/+ mice, females had higher circulating angiopoietin-2 (138%, p<0.05) compared to males. Gene expression of angiopoietin-1 (204%, p<0.01), angiopoietin-2 (542%, p<0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in both organs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2.sup.+/+ females and males. Tie2.sup.+/+ females had lower circulating NGAL (41%, p<0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected. Interestingly, male Tie2.sup.+/- mice had 28% higher renal wet/dry weight ratio (p<0.05) compared to Tie2.sup.+/+ males, which was not observed in females nor in lungs. Partial deletion of Tie2 did not affect circulating angiopoietin-1 or angiopoietin-2, but soluble Tie2 was 44% and 53% lower in males and females, respectively, compared to Tie2.sup.+/+ mice of the same sex. Renal and pulmonary gene expression of angiopoietin-1, angiopoietin-2, estrogen receptors and other endothelial barrier regulators was comparable between Tie2.sup.+/- and Tie2.sup.+/+ mice in both sexes. Conclusion Female sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system. BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation.MethodsAdult male and female heterozygous Tie2 knockout mice (Tie2+/-) and wild-type controls (Tie2+/+) were included (n = 9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR.ResultsIn Tie2+/+ mice, females had higher circulating angiopoietin-2 (138%, p<0.05) compared to males. Gene expression of angiopoietin-1 (204%, p<0.01), angiopoietin-2 (542%, p<0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in both organs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2+/+ females and males. Tie2+/+ females had lower circulating NGAL (41%, p<0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected. Interestingly, male Tie2+/- mice had 28% higher renal wet/dry weight ratio (p<0.05) compared to Tie2+/+ males, which was not observed in females nor in lungs. Partial deletion of Tie2 did not affect circulating angiopoietin-1 or angiopoietin-2, but soluble Tie2 was 44% and 53% lower in males and females, respectively, compared to Tie2+/+ mice of the same sex. Renal and pulmonary gene expression of angiopoietin-1, angiopoietin-2, estrogen receptors and other endothelial barrier regulators was comparable between Tie2+/- and Tie2+/+ mice in both sexes.ConclusionFemale sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system. Background The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation. Methods Adult male and female heterozygous Tie2 knockout mice (Tie2 +/− ) and wild-type controls (Tie2 +/+ ) were included (n = 9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR. Results In Tie2 +/+ mice, females had higher circulating angiopoietin-2 (138%, p<0.05) compared to males. Gene expression of angiopoietin-1 (204%, p<0.01), angiopoietin-2 (542%, p<0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in both organs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2 +/+ females and males. Tie2 +/+ females had lower circulating NGAL (41%, p<0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected. Interestingly, male Tie2 +/- mice had 28% higher renal wet/dry weight ratio (p<0.05) compared to Tie2 +/+ males, which was not observed in females nor in lungs. Partial deletion of Tie2 did not affect circulating angiopoietin-1 or angiopoietin-2, but soluble Tie2 was 44% and 53% lower in males and females, respectively, compared to Tie2 +/+ mice of the same sex. Renal and pulmonary gene expression of angiopoietin-1, angiopoietin-2, estrogen receptors and other endothelial barrier regulators was comparable between Tie2 +/- and Tie2 +/+ mice in both sexes. Conclusion Female sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system. The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation. Adult male and female heterozygous Tie2 knockout mice (Tie2.sup.+/-) and wild-type controls (Tie2.sup.+/+) were included (n = 9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR. In Tie2.sup.+/+ mice, females had higher circulating angiopoietin-2 (138%, p<0.05) compared to males. Gene expression of angiopoietin-1 (204%, p<0.01), angiopoietin-2 (542%, p<0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in both organs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2.sup.+/+ females and males. Tie2.sup.+/+ females had lower circulating NGAL (41%, p<0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected. Female sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system. BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation.MethodsAdult male and female heterozygous Tie2 knockout mice (Tie2+/−) and wild-type controls (Tie2+/+) were included (n = 9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR.ResultsIn Tie2+/+ mice, females had higher circulating angiopoietin-2 (138%, p<0.05) compared to males. Gene expression of angiopoietin-1 (204%, p<0.01), angiopoietin-2 (542%, p<0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in both organs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2+/+ females and males. Tie2+/+ females had lower circulating NGAL (41%, p<0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected.Interestingly, male Tie2+/- mice had 28% higher renal wet/dry weight ratio (p<0.05) compared to Tie2+/+ males, which was not observed in females nor in lungs. Partial deletion of Tie2 did not affect circulating angiopoietin-1 or angiopoietin-2, but soluble Tie2 was 44% and 53% lower in males and females, respectively, compared to Tie2+/+ mice of the same sex. Renal and pulmonary gene expression of angiopoietin-1, angiopoietin-2, estrogen receptors and other endothelial barrier regulators was comparable between Tie2+/- and Tie2+/+ mice in both sexes.ConclusionFemale sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system. The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation.BACKGROUNDThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation.Adult male and female heterozygous Tie2 knockout mice (Tie2+/-) and wild-type controls (Tie2+/+) were included (n = 9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR.METHODSAdult male and female heterozygous Tie2 knockout mice (Tie2+/-) and wild-type controls (Tie2+/+) were included (n = 9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR.In Tie2+/+ mice, females had higher circulating angiopoietin-2 (138%, p<0.05) compared to males. Gene expression of angiopoietin-1 (204%, p<0.01), angiopoietin-2 (542%, p<0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in both organs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2+/+ females and males. Tie2+/+ females had lower circulating NGAL (41%, p<0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected. Interestingly, male Tie2+/- mice had 28% higher renal wet/dry weight ratio (p<0.05) compared to Tie2+/+ males, which was not observed in females nor in lungs. Partial deletion of Tie2 did not affect circulating angiopoietin-1 or angiopoietin-2, but soluble Tie2 was 44% and 53% lower in males and females, respectively, compared to Tie2+/+ mice of the same sex. Renal and pulmonary gene expression of angiopoietin-1, angiopoietin-2, estrogen receptors and other endothelial barrier regulators was comparable between Tie2+/- and Tie2+/+ mice in both sexes.RESULTSIn Tie2+/+ mice, females had higher circulating angiopoietin-2 (138%, p<0.05) compared to males. Gene expression of angiopoietin-1 (204%, p<0.01), angiopoietin-2 (542%, p<0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in both organs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2+/+ females and males. Tie2+/+ females had lower circulating NGAL (41%, p<0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected. Interestingly, male Tie2+/- mice had 28% higher renal wet/dry weight ratio (p<0.05) compared to Tie2+/+ males, which was not observed in females nor in lungs. Partial deletion of Tie2 did not affect circulating angiopoietin-1 or angiopoietin-2, but soluble Tie2 was 44% and 53% lower in males and females, respectively, compared to Tie2+/+ mice of the same sex. Renal and pulmonary gene expression of angiopoietin-1, angiopoietin-2, estrogen receptors and other endothelial barrier regulators was comparable between Tie2+/- and Tie2+/+ mice in both sexes.Female sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system.CONCLUSIONFemale sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system.
Audience	Academic
Author	Ibelings, Roselique van Meurs, Matijs van Leeuwen, Anoek L. I. van den Brom, Charissa E. Roelofs, Joris J. T. H. Molema, Grietje Beijer, Elise van der Steen, Marjolein R. A. Dekker, Nicole A. M.
Author_xml	– sequence: 1 givenname: Anoek L. I. orcidid: 0000-0001-6552-0830 surname: van Leeuwen fullname: van Leeuwen, Anoek L. I. – sequence: 2 givenname: Elise orcidid: 0000-0003-1982-458X surname: Beijer fullname: Beijer, Elise – sequence: 3 givenname: Roselique surname: Ibelings fullname: Ibelings, Roselique – sequence: 4 givenname: Nicole A. M. surname: Dekker fullname: Dekker, Nicole A. M. – sequence: 5 givenname: Marjolein R. A. surname: van der Steen fullname: van der Steen, Marjolein R. A. – sequence: 6 givenname: Joris J. T. H. surname: Roelofs fullname: Roelofs, Joris J. T. H. – sequence: 7 givenname: Matijs surname: van Meurs fullname: van Meurs, Matijs – sequence: 8 givenname: Grietje orcidid: 0000-0002-4147-6676 surname: Molema fullname: Molema, Grietje – sequence: 9 givenname: Charissa E. orcidid: 0000-0002-0886-1388 surname: van den Brom fullname: van den Brom, Charissa E.
BookMark	eNqNkmFr1DAYx4tMcJt-A8GAIAre2SRtmvhujE0PBgOdvg1p8rSXI9ecSYrzo-zbmnp3shtDpC_SPP39_0_y9H9SHA1-gKJ4ics5pg3-sPJjGJSbb3J5XhJBWUOfFMdYUDJjpKRH996fFScxrsqyppyx4-LuEtbKAYpwizbBJ9ApItUrO8SEAmRXBCYj71E7JjT4hNw49PuaHdDaakA_bVqijQrJZt6Ag2T9gHyH0hIQDMbn1U3fWhWChZCd-9Gp5AO6sUCQ9uusBoOSR_vjPC-edspFeLFbT4tvlxc3559nV9efFudnVzPNcJVmmBPoqk6RWnQC13knCMWEK1qJSnPeCGJEhWvCmOKYtrw0Ruu2NXVdAalqelq82vpunI9yN8ooackE4WXDRSYWW8J4tZKbYNcq_JJeWfmn4EMvp6trB5IonZtSY2pWVbrmCvNO8RYDY9OmyV5vd92C_zFCTHJtowbn1AB-jJJwgZu6JpRl9PUD9PHD7ag-z03aofMpKD2ZyrOmoSUXrJnazh-h8pP_o9U5Np3N9QPBuwNBZhLcpl6NMcrF1y__z15_P2Tf3GOXoFxaRu_GKTDxEKy2oA4-xgDd38HjUk6p309DTqmXu9Rn2ccHMm2Tmtzzha37t_g3NtEKGA
CitedBy_id	crossref_primary_10_3390_ijms26073000
Cites_doi	10.1186/cc13806 10.1016/j.amjsurg.2015.03.021 10.1371/journal.pbio.3000411 10.1084/jem.20090389 10.1002/mrd.21163 10.1097/TA.0000000000001113 10.1016/j.injury.2014.08.013 10.1016/j.surg.2009.05.006 10.1161/01.HYP.37.2.645 10.1097/00024382-200301000-00006 10.1159/000049033 10.1097/CCM.0b013e3181760c14 10.1084/jem.20150718 10.1161/01.RES.0000218275.54089.12 10.1097/CCM.0000000000003269 10.1097/SHK.0b013e3181b2f978 10.1016/j.ccc.2019.12.003 10.1186/s13293-014-0018-2 10.1016/j.surg.2004.04.037 10.1097/ALN.0000000000001907 10.1083/jcb.200507082 10.1152/ajprenal.00049.2017 10.1016/S0039-128X(01)00163-5 10.1093/cvr/cvq142 10.1186/s13049-019-0589-3 10.1016/j.cyto.2016.03.019 10.1007/s12020-006-0012-5 10.1016/B978-012369454-6/50074-1 10.1007/978-3-319-77932-4_20 10.1213/ANE.0000000000005023 10.3233/CH-190642 10.1161/CIRCGENETICS.109.914556 10.1073/pnas.1519467113 10.1186/s40635-021-00389-5 10.1016/j.bja.2018.05.049 10.1016/j.genm.2008.03.002 10.1242/jcs.017897 10.1152/ajprenal.00137.2009 10.1038/s41419-020-2486-0 10.1042/CS20190379 10.1371/journal.pone.0009421 10.2741/4347 10.1124/jpet.112.201061 10.1038/nrg2415 10.1097/SHK.0000000000001226
ContentType	Journal Article
Copyright	COPYRIGHT 2023 Public Library of Science 2023 van Leeuwen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright: © 2023 van Leeuwen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2023 van Leeuwen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: COPYRIGHT 2023 Public Library of Science – notice: 2023 van Leeuwen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright: © 2023 van Leeuwen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. – notice: 2023 van Leeuwen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	AAYXX CITATION IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 DOA
DOI	10.1371/journal.pone.0293673
DatabaseName	CrossRef Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Materials Science & Engineering ProQuest Central (Alumni) One Sustainability ProQuest Central Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Database ProQuest Central Essentials Biological Science Database ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection (ProQuest) ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database ProQuest Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Databases ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Agricultural Science Database MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Open Access Full Text url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: PIMPY name: ProQuest Publicly Available Content url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General)
EISSN	1932-6203
ExternalDocumentID	3069280789 oai_doaj_org_article_2ac4c83dd5644c58a18fa8b1e6658a17 A773089677 10_1371_journal_pone_0293673
GeographicLocations	Netherlands Minneapolis Minnesota United States--US
GeographicLocations_xml	– name: Netherlands – name: Minneapolis Minnesota – name: United States--US
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO
ID	FETCH-LOGICAL-c614t-182ef4fa259f91582e923128a3494c88792d9415266a813b80ddccbbd554e2453
IEDL.DBID	M7P
ISICitedReferencesCount	1
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001119675000120&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Thu Nov 28 02:59:45 EST 2024 Mon Nov 10 04:31:54 EST 2025 Wed Oct 01 13:14:30 EDT 2025 Tue Oct 07 07:52:25 EDT 2025 Sat Nov 29 14:15:05 EST 2025 Sat Nov 29 10:59:02 EST 2025 Wed Nov 26 11:14:03 EST 2025 Wed Nov 26 11:17:26 EST 2025 Thu May 22 21:21:45 EDT 2025 Tue Nov 18 20:57:44 EST 2025 Sat Nov 29 05:40:33 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	11
Language	English
License	Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c614t-182ef4fa259f91582e923128a3494c88792d9415266a813b80ddccbbd554e2453
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0003-1982-458X 0000-0002-4147-6676 0000-0001-6552-0830 0000-0002-0886-1388
OpenAccessLink	https://www.proquest.com/docview/3069280789?pq-origsite=%requestingapplication%
PQID	3069280789
PQPubID	1436336
PageCount	e0293673
ParticipantIDs	plos_journals_3069280789 doaj_primary_oai_doaj_org_article_2ac4c83dd5644c58a18fa8b1e6658a17 proquest_miscellaneous_2891755236 proquest_journals_3069280789 gale_infotracmisc_A773089677 gale_infotracacademiconefile_A773089677 gale_incontextgauss_ISR_A773089677 gale_incontextgauss_IOV_A773089677 gale_healthsolutions_A773089677 crossref_primary_10_1371_journal_pone_0293673 crossref_citationtrail_10_1371_journal_pone_0293673
PublicationCentury	2000
PublicationDate	2023-11-16
PublicationDateYYYYMMDD	2023-11-16
PublicationDate_xml	– month: 11 year: 2023 text: 2023-11-16 day: 16
PublicationDecade	2020
PublicationPlace	San Francisco
PublicationPlace_xml	– name: San Francisco
PublicationTitle	PloS one
PublicationYear	2023
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	T Liu (pone.0293673.ref001) 2015; 210 E Dejana (pone.0293673.ref018) 2008; 121 K Flurkey (pone.0293673.ref027) 2007 AH Haider (pone.0293673.ref007) 2009; 146 W Lieb (pone.0293673.ref029) 2010; 3 TW Bonagura (pone.0293673.ref032) 2010; 77 M van der Heijden (pone.0293673.ref019) 2010; 33 M Frye (pone.0293673.ref017) 2015; 212 NP Juffermans (pone.0293673.ref023) 2020; 131 J Neugarten (pone.0293673.ref046) 2002; 90 K Thamm (pone.0293673.ref030) 2018; 46 S Cvitic (pone.0293673.ref042) 2020; 134 R Boddu (pone.0293673.ref048) 2017; 313 H Liu (pone.0293673.ref009) 2015; 20 MC Lopez (pone.0293673.ref003) 2016; 81 F Ye (pone.0293673.ref034) 2002; 67 D Doucet (pone.0293673.ref043) 2010; 5 VH Huxley (pone.0293673.ref024) 2018; 1065 A Aslan (pone.0293673.ref036) 2014; 18 K Thamm (pone.0293673.ref014) 2016; 83 JL Sperry (pone.0293673.ref004) 2008; 36 VH Huxley (pone.0293673.ref039) 2010; 87 M Trieu (pone.0293673.ref012) 2018; 128 N Percie du Sert (pone.0293673.ref025) 2020; 18 H Trentzsch (pone.0293673.ref005) 2014; 45 I Cascone (pone.0293673.ref020) 2005; 170 P Ananthakrishnan (pone.0293673.ref044) 2005; 137 C Ober (pone.0293673.ref031) 2008; 9 S Xiao (pone.0293673.ref047) 2001; 37 J Gu (pone.0293673.ref035) 2020; 11 S David (pone.0293673.ref016) 2013; 345 NP Brindle (pone.0293673.ref015) 2006; 98 L Kugathasan (pone.0293673.ref038) 2009; 206 ALI van Leeuwen (pone.0293673.ref010) 2021; 9 AH Haider (pone.0293673.ref008) 2010; 69 M van Meurs (pone.0293673.ref021) 2009; 297 pone.0293673.ref028 RM Jongman (pone.0293673.ref026) 2019; 51 CC Ghosh (pone.0293673.ref037) 2016; 113 NAM Dekker (pone.0293673.ref022) 2018; 121 S Silbiger (pone.0293673.ref045) 2008; 5 M Pape (pone.0293673.ref006) 2019; 27 ALI van Leeuwen (pone.0293673.ref011) 2020; 75 KD Sack (pone.0293673.ref013) 2020; 36 ML Johnson (pone.0293673.ref033) 2006; 30 AC Shore (pone.0293673.ref040) 1995; 268 RL George (pone.0293673.ref002) 2003; 19 R Addis (pone.0293673.ref041) 2014; 5
References_xml	– volume: 18 start-page: 423 year: 2014 ident: pone.0293673.ref036 article-title: The renal angiopoietin/Tie2 system in lethal human sepsis publication-title: Crit Care doi: 10.1186/cc13806 – volume: 210 start-page: 911 year: 2015 ident: pone.0293673.ref001 article-title: The influence of sex on outcomes in trauma patients: a meta-analysis publication-title: Am J Surg doi: 10.1016/j.amjsurg.2015.03.021 – volume: 18 start-page: e3000411 year: 2020 ident: pone.0293673.ref025 article-title: Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 publication-title: PLoS Biol doi: 10.1371/journal.pbio.3000411 – volume: 206 start-page: 2221 year: 2009 ident: pone.0293673.ref038 article-title: The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice publication-title: J Exp Med doi: 10.1084/jem.20090389 – volume: 77 start-page: 430 year: 2010 ident: pone.0293673.ref032 article-title: Divergent regulation of angiopoietin-1 and -2, Tie-2, and thrombospondin-1 expression by estrogen in the baboon endometrium publication-title: Mol Reprod Dev doi: 10.1002/mrd.21163 – volume: 81 start-page: 478 year: 2016 ident: pone.0293673.ref003 article-title: Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock publication-title: J Trauma Acute Care Surg doi: 10.1097/TA.0000000000001113 – volume: 45 start-page: S20 issue: Suppl 3 year: 2014 ident: pone.0293673.ref005 article-title: Female sex protects from organ failure and sepsis after major trauma haemorrhage publication-title: Injury doi: 10.1016/j.injury.2014.08.013 – volume: 146 start-page: 308 year: 2009 ident: pone.0293673.ref007 article-title: Females have fewer complications and lower mortality following trauma than similarly injured males: a risk adjusted analysis of adults in the National Trauma Data Bank publication-title: Surgery doi: 10.1016/j.surg.2009.05.006 – volume: 37 start-page: 645 year: 2001 ident: pone.0293673.ref047 article-title: Effects of estradiol and its metabolites on glomerular endothelial nitric oxide synthesis and mesangial cell growth publication-title: Hypertension doi: 10.1161/01.HYP.37.2.645 – volume: 19 start-page: 28 year: 2003 ident: pone.0293673.ref002 article-title: Age-related gender differential in outcome after blunt or penetrating trauma publication-title: Shock doi: 10.1097/00024382-200301000-00006 – volume: 90 start-page: 139 year: 2002 ident: pone.0293673.ref046 article-title: Effects of sex on renal structure publication-title: Nephron doi: 10.1159/000049033 – volume: 36 start-page: 1838 year: 2008 ident: pone.0293673.ref004 article-title: Inflammation and the Host Response to Injury Investigators. Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible? publication-title: Crit Care Med doi: 10.1097/CCM.0b013e3181760c14 – volume: 212 start-page: 2267 year: 2015 ident: pone.0293673.ref017 article-title: Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin publication-title: J Exp Med doi: 10.1084/jem.20150718 – volume: 98 start-page: 1014 year: 2006 ident: pone.0293673.ref015 article-title: Signaling and functions of angiopoietin-1 in vascular protection publication-title: Circ Res doi: 10.1161/01.RES.0000218275.54089.12 – volume: 46 start-page: e928 year: 2018 ident: pone.0293673.ref030 article-title: Molecular Regulation of Acute Tie2 Suppression in Sepsis publication-title: Crit Care Med doi: 10.1097/CCM.0000000000003269 – volume: 33 start-page: 263 issue: 3 year: 2010 ident: pone.0293673.ref019 article-title: The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients publication-title: Shock doi: 10.1097/SHK.0b013e3181b2f978 – volume: 36 start-page: 201 year: 2020 ident: pone.0293673.ref013 article-title: The Angiopoietin-Tie2 Pathway in Critical Illness publication-title: Crit Care Clin doi: 10.1016/j.ccc.2019.12.003 – volume: 5 start-page: 18 year: 2014 ident: pone.0293673.ref041 article-title: Human umbilical endothelial cells (HUVECs) have a sex: characterisation of the phenotype of male and female cells publication-title: Biol Sex Differ doi: 10.1186/s13293-014-0018-2 – volume: 137 start-page: 56 year: 2005 ident: pone.0293673.ref044 article-title: Sex hormones modulate distant organ injury in both a trauma/hemorrhagic shock model and a burn model publication-title: Surgery doi: 10.1016/j.surg.2004.04.037 – volume: 128 start-page: 361 year: 2018 ident: pone.0293673.ref012 article-title: Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock publication-title: Anesthesiology doi: 10.1097/ALN.0000000000001907 – volume: 170 start-page: 993 issue: 6 year: 2005 ident: pone.0293673.ref020 article-title: Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1 publication-title: J Cell Biol doi: 10.1083/jcb.200507082 – volume: 313 start-page: F740 issue: 3 year: 2017 ident: pone.0293673.ref048 article-title: Unique sex- and age-dependent effects in protective pathways in acute kidney injury publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00049.2017 – volume: 67 start-page: 305 year: 2002 ident: pone.0293673.ref034 article-title: Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen publication-title: Steroids doi: 10.1016/S0039-128X(01)00163-5 – volume: 87 start-page: 230 year: 2010 ident: pone.0293673.ref039 article-title: Cardiovascular sex differences influencing microvascular exchange publication-title: Cardiovasc Res doi: 10.1093/cvr/cvq142 – volume: 27 start-page: 16 year: 2019 ident: pone.0293673.ref006 article-title: Is there an association between female gender and outcome in severe trauma? A multi-center analysis in the Netherlands publication-title: Scand J Trauma Resusc Emerg Med doi: 10.1186/s13049-019-0589-3 – volume: 83 start-page: 61 year: 2016 ident: pone.0293673.ref014 article-title: Role of angiopoietin-2 in infection—A double-edged sword? publication-title: Cytokine doi: 10.1016/j.cyto.2016.03.019 – volume: 30 start-page: 333 year: 2006 ident: pone.0293673.ref033 article-title: Effects of estradiol-17beta on expression of mRNA for seven angiogenic factors and their receptors in the endometrium of ovariectomized (OVX) ewes publication-title: Endocrine doi: 10.1007/s12020-006-0012-5 – volume: 69 start-page: 537 year: 2010 ident: pone.0293673.ref008 article-title: Evidence of hormonal basis for improved survival among females with trauma-associated shock: an analysis of the National Trauma Data Bank publication-title: J Trauma – start-page: 637 volume-title: The Mouse in Biomedical Research year: 2007 ident: pone.0293673.ref027 doi: 10.1016/B978-012369454-6/50074-1 – volume: 1065 start-page: 307 year: 2018 ident: pone.0293673.ref024 article-title: Sex-Specific Characteristics of the Microcirculation publication-title: Adv Exp Med Biol doi: 10.1007/978-3-319-77932-4_20 – volume: 131 start-page: 1708 year: 2020 ident: pone.0293673.ref023 article-title: Targeting Endothelial Dysfunction in Acute Critical Illness to Reduce Organ Failure publication-title: Anesth Analg doi: 10.1213/ANE.0000000000005023 – volume: 75 start-page: 121 year: 2020 ident: pone.0293673.ref011 article-title: In vitro endothelial hyperpermeability occurs early following traumatic hemorrhagic shock publication-title: Clin Hemorheol Microcirc doi: 10.3233/CH-190642 – volume: 3 start-page: 300 year: 2010 ident: pone.0293673.ref029 article-title: Clinical and genetic correlates of circulating angiopoietin-2 and soluble Tie-2 in the community publication-title: Circ Cardiovasc Genet doi: 10.1161/CIRCGENETICS.109.914556 – volume: 268 start-page: H147 year: 1995 ident: pone.0293673.ref040 article-title: Capillary pressure, pulse pressure amplitude, and pressure waveform in healthy volunteers publication-title: Am J Physiol – volume: 113 start-page: 2472 year: 2016 ident: pone.0293673.ref037 article-title: Gene control of tyrosine kinase TIE2 and vascular manifestations of infections publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1519467113 – volume: 9 start-page: 23 year: 2021 ident: pone.0293673.ref010 article-title: The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats publication-title: Intensive Care Med Exp doi: 10.1186/s40635-021-00389-5 – volume: 121 start-page: 1041 year: 2018 ident: pone.0293673.ref022 article-title: Vasculotide, an angiopoietin-1 mimetic, reduces pulmonary vascular leakage and preserves microcirculatory perfusion during cardiopulmonary bypass in rats publication-title: Br J Anaesth doi: 10.1016/j.bja.2018.05.049 – volume: 5 start-page: S3 issue: Suppl A year: 2008 ident: pone.0293673.ref045 article-title: Gender and human chronic renal disease publication-title: Gend Med doi: 10.1016/j.genm.2008.03.002 – volume: 121 start-page: 2115 issue: Pt 13 year: 2008 ident: pone.0293673.ref018 article-title: The role of adherens junctions and VE-cadherin in the control of vascular permeability publication-title: J Cell Sci doi: 10.1242/jcs.017897 – volume: 297 start-page: F272 year: 2009 ident: pone.0293673.ref021 article-title: Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00137.2009 – volume: 11 start-page: 367 year: 2020 ident: pone.0293673.ref035 article-title: Targeting the ERbeta/Angiopoietin-2/Tie-2 signaling-mediated angiogenesis with the FDA-approved anti-estrogen Faslodex to increase the Sunitinib sensitivity in RCC publication-title: Cell Death Dis doi: 10.1038/s41419-020-2486-0 – volume: 134 start-page: 39 year: 2020 ident: pone.0293673.ref042 article-title: Sexual dimorphism of miRNA signatures in feto-placental endothelial cells is associated with altered barrier function and actin organization publication-title: Clin Sci (Lond) doi: 10.1042/CS20190379 – volume: 5 start-page: e9421 year: 2010 ident: pone.0293673.ref043 article-title: Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats publication-title: PLoS One doi: 10.1371/journal.pone.0009421 – volume: 20 start-page: 927 year: 2015 ident: pone.0293673.ref009 article-title: Systemic inflammation and multiple organ injury in traumatic hemorrhagic shock publication-title: Front Biosci (Landmark Ed) doi: 10.2741/4347 – volume: 345 start-page: 2 issue: 1 year: 2013 ident: pone.0293673.ref016 article-title: Mending leaky blood vessels: the angiopoietin-Tie2 pathway in sepsis publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.112.201061 – volume: 9 start-page: 911 year: 2008 ident: pone.0293673.ref031 article-title: Sex-specific genetic architecture of human disease publication-title: Nat Rev Genet doi: 10.1038/nrg2415 – volume: 51 start-page: 757 year: 2019 ident: pone.0293673.ref026 article-title: Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in A Vascular Bed and Organ-Specific Way publication-title: Shock doi: 10.1097/SHK.0000000000001226 – ident: pone.0293673.ref028
SSID	ssj0053866
Score	2.4409304
Snippet	Background The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced... The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema... BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced... Background The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced...
SourceID	plos doaj proquest gale crossref
SourceType	Open Website Aggregation Database Enrichment Source Index Database
StartPage	e0293673
SubjectTerms	Angiopoietin Animals Circulation Deletion Demographic aspects Diagnosis Dropsy Dry weight Edema Endothelium Enzyme-linked immunosorbent assay Estrogen Estrogen receptors Estrogens Ethylenediaminetetraacetic acid Experiments Females Gender differences Gene expression Genes Hemorrhagic shock Kidneys Kinases Lungs Males Neutrophils Permeability Phosphatase Phosphorylation Proteins R&D Renal agenesis Research & development Risk factors RNA Sex differences Sexual dimorphism Vascular endothelial growth factor Weight
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA-y-OCLeH5wq6eOIqhg79q0TdvHU1z05RQ95d5CmqTHwtouTVf8V_xvnUnT4qJwPvjY5NfQzkzmo83MMPYsr8tYVzqONJqfKDOViZRRCmMeYXlRVHXNjW82UZydlRcX1cffWn3RmbCxPPBIuBOudKbL1JgcLbfOS5WUjSrrxApBFz6PHL2eKZgadTDuYiFColxaJCeBL8fbrrXHMVo4UaR7hsjX65-18mK76dwfytlbnNUtdjO4inA6PuIBu2bb2-wgbEYHL0LF6Jd32M-V_YZLgrM_IBRecKAuMeh3A_SWVrEGIa-g3g3QdgNscI9PY-sWqCc90CdZ2BJFEE_9cYhn0DWAPiLY1lCu1obmatVTnztc2fex73o4X1sO03F2GDqYHucu-7J6e_7mXRR6LkQaDfUQYbhhm6xRGBU1VZLjFXmAvFRUxkajRqq4qcjoC6HKJEVOG6N1XRt0SyzP8vQeW7RI5UMGhVB5o7PUxrHNKAE4s5rcRYxIbZ4W-ZKlEwOkDgXJqS_GRvq_bAUGJiOhJbFNBrYtWTTftR0LclyBf028nbFUTtsPoJDJIGTyKiFbssckGXLMTZ2VgjwtUEGWlSgQ8dQjqKRGS2d2LtXOOfn-w9d_AH3-tAd6HkBNh-TQKuRJ4DtRqa495NEeEhWD3ps-JDmeqOIkRocV9_0F8M5Jtv8-_WSepkXpHF5ru52TGJ6jv5nzVNz_H3R9wG5wdBoptzMRR2wx9Dv7kF3X34e16x_5Lf0LflFQ8A priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1fb9QwDI_g4IEXYPzRbgwwCAmQ6GjTNmkfB-IEEhoTDLS3KE3S6aRbe2p7iK_Ct8XupUUFJuCxzS9R4tiO3cY2Y0_SIgtNbsLA4PETJDa3gbZao88jHJcyLwpu-2IT8ugoOz3Nj386ir_8wY9l9NLT9GBdV-4gxNNJyPgyu8JjIegK1-L4_aB5UXaF8OFxF_WcHD99lv5RF8_Wq7r9TSX358zixv_O8Ca77i1KONyywA675KpbbMfLbAvPfGLp57fZ94U7xzlA676Bz8_Qgj7TSzQRoXE0irMIeQHFpoOq7mCFqmB4t6yAStcDfbmFNXEc4qmMDm0t1CWgKQmushTStaK2QjdUDg9H7svd1w2cLB2H4dY7dDUM07nDPi_enLx-G_jSDIHB87wL0CtxZVJqdJ7KPErxiQxFnmnKdmNQceXc5mQbCKGzKEaGsNaYorBovTiepPFdNquQXLsMpNBpaZLYhaFLKE44cYasSnRcXRrLdM7iYceU8XnLqXzGSvU_4yT6L1tCK6K_8vSfs2Dstd7m7fgL_hUxw4ilrNv9C9xo5YVYcW1wcbG1KVqRJs10lJU6KyInBD3IOXtIrKS2Iayj7lCHEvVolguJiMc9gjJvVHS150xv2la9-_DlH0CfPk5ATz2orJEcRvtwClwTZfSaIPcnSNQfZtK8S4w_UKVV6ETmvC9DgD0HYfhz86OxmQal63qVqzetQi8ezdIUZXTv4tHvsWscLUYK7IzEPpt1zcbdZ1fN127ZNg96yf4Bo05NTw priority: 102 providerName: Public Library of Science
Title	Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex
URI	https://www.proquest.com/docview/3069280789 https://www.proquest.com/docview/2891755236 https://doaj.org/article/2ac4c83dd5644c58a18fa8b1e6658a17 http://dx.doi.org/10.1371/journal.pone.0293673
Volume	18
WOSCitedRecordID	wos001119675000120&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Open Access Full Text customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: PROQUEST customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1db9Mw0GIdD7wA40MrjGIQEiCRLp928oTWaRXTWIm6MXW8RI7tVJVKUpIW8Vf4t9y5TlEFAiReTkp8thzf-Xzn3AchL6I8dmUiXUfC8eOEKlGOUEKAzcO0z3mS574yxSb4aBRPJklqL9wa61bZykQjqFUl8Y78EFTbxDfJ0d8uvjhYNQr_rtoSGjtkF7MkBMZ1L20lMexlxmy4XMC9Q0ud_qIqdd-Fc47xYOs4Mln7N7K5s5hXzS8i2pw7wzv_O-O75LbVOOnRmkX2yA1d3iN7dk839JVNPP36Pvk-1J9hTrTR36jN39BQMRUzUCFprXEUrQDlDc1XS1pWSzoHUdG-m5UUS9tTvNmlC-RIwMcyO0h6WhUUVE2qS4UhX3Nsy0WN5fJg5CnWEKtqejnTPm294umyou10HpCPw5PL43eOLd3gSDjvlw5YLboICwHGVZF4ETyhIunHArPhSBBsia8S1B0YE7EXAMMoJWWeK9ButB9GwUPSKYFM-4RyJqJChoF2XR1iHHGoJWqdYNjqKOBRlwQtBTNp85pjeY15Zn7WcbBv1gudId0zS_cucTa9Fuu8Hn_BHyBzbHAxK7d5UdXTzG7yzBcSPi5QKgItU0ax8OJCxLmnGcMH3iVPkbWydYjrRrZkRxzkbJwwDhjPDQZm5ijR9WcqVk2TnX64-geki_EW0kuLVFSwHFLYcAv4Jsz4tYV5sIUJ8kVuNe_jRmhXpcl-8jX0bDn_983PNs04KLrzlbpaNRlY-aC2Rn7AHv15iMfklg9aJQZ_euyAdJb1Sj8hN-XX5aype2SHj68QTriBMcD42OuR3cHJKB33zAULwGH6HuDZoA_w3D3rGSlh4AXANPoEPdLT8_T6Bx5na6Q
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELemMglegPGhFQYzCARIZGucxE4e0DQ-qlUbBY0y7c04tlNV6pKSpHz8KfwT_I3cpU5RBQJe9sBj4otVX-9-93PiuyPkQZTGPZ3onqch_HihSYynjFKw5-GWCZGkKTNNswkxHManp8nbNfK9zYXBY5UtJjZAbQqN78h3gdomrCmOvjf76GHXKPy62rbQWJjFof36GbZs1bPBS_h_HzLWfzV6ceC5rgKehlBUe0CobRZmCnh_lvgRXCHHYbHCQi0afC5hJsGwxrmK_QDWYozWaWog8FoWYpcIgPwLgOM-HiETxyct8gN2cO7S8wLh7zpr2JkVud3pQVzlIlgJf02XgGUs6MymRfVLSGjiXP_K_6ahq-SyY9R0f-ECG2TN5tfIhsOsij52hbWfXCff-vYMdEAr-4W6-hQVVWM1AYpMS4uzWAMiT2k6r2le1HQKUNjem-T0DFCV4ptrOkOPA3lsI4SmTYuMApWmNjeY0jbFsVSV2A4QZh5jj7SipKOJZbQ99U_rgrY_5wZ5fy4qukk6OZjFJqGCqyjTYWB7PRtinnRoNbJq2LjbKBBRlwStxUjt6rZj-5CpbD5GCti_LRQt0c6ks7Mu8ZZPzRZ1S_4i_xyNcSmLVcebG0U5lg7EJFMaFhcYEwGL1lGs_DhTcepbzvFCdMk2mrJcpPAusVPuC4gjccIFSNxvJLDySI5Hm8ZqXlVy8ObkH4TeHa8IPXJCWQHq0Mqlk8CasKLZiuTWiiTgp14Z3kTHa7VSyZ9-BE-2nvb74XvLYZwUjyvmtphXksUJ0PKIBfzWn6fYJhcPRq-P5NFgeHibXGLAoDHR1edbpFOXc3uHrOtP9aQq7zZIQ8mH83bcH2pruSg
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLamghAvwLhohcEMAgESWRsnsZMHhMZGRTVUJhhob8axnapSl5Qk5fJT-Cv8Os5JnaAKBLzsgcfEX6z69DsXJz7nEHI_SuOhTvTQ0-B-vNAkxlNGKdjzcMuESNKUmabZhJhM4pOT5GiDfG9zYfBYZWsTG0NtCo3vyAcQ2iasKY4-yNyxiKOD0bPFRw87SOGX1radxooih_brZ9i-VU_HB_BfP2Bs9OJ4_6XnOgx4GtxS7UFwbbMwU7AHyBI_giuMd1issGiLBv1LmEnQxXGuYj-AdRmjdZoacMKWhdgxAsz_OREAizFLfb87XgJ2hHOXqhcIf-CYsbsocrs7BB_LRbDmCpuOAZ1f6C3mRfWLe2h83ujy_yytK-SSi7Tp3ko1NsmGza-STWfLKvrIFdx-fI18G9lTkAet7Bfq6lZUVE3VDEJnWlqcxRqAPKHpsqZ5UdM5mMj23iynp2BtKb7RpgvURMBjeyGkPC0yCiE2tbnBVLc5jqWqxDaBMPMUe6cVJT2eWUbbbABaF7T9OdfJuzMR0Q3Sy4EiW4QKrqJMh4EdDm2I-dOh1Rhtw4beRoGI-iRo2SO1q-eObUXmsvlIKWBftxK0RM5Jx7k-8bqnFqt6Jn_BP0didlisRt7cKMqpdMZNMqVhcYExEUTXOoqVH2cqTn3LOV6IPtlBWstVam9nU-WeAP8SJ1wA4l6DwIokObJ1qpZVJcev3_8D6O2bNdBDB8oKEIdWLs0E1oSVztaQ22tIsKt6bXgLlbCVSiV_6hQ82Wrd74fvdsM4KR5jzG2xrCSLEwjXIxbwm3-eYodcAH2Vr8aTw1vkIoPAGvNffb5NenW5tLfJef2pnlXlncboUPLhrPX2BymdwYM
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Female+sex+protects+against+renal+edema%2C+but+not+lung+edema%2C+in+mice+with+partial+deletion+of+the+endothelial+barrier+regulator+Tie2+compared+to+male+sex&rft.jtitle=PloS+one&rft.au=van+Leeuwen%2C+Anoek+L.+I&rft.au=Beijer%2C+Elise&rft.au=Ibelings%2C+Roselique&rft.au=Dekker%2C+Nicole+A.+M&rft.date=2023-11-16&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=18&rft.issue=11&rft.spage=e0293673&rft_id=info:doi/10.1371%2Fjournal.pone.0293673&rft.externalDBID=IOV&rft.externalDocID=A773089677
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon