Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistence

Background Mycobacterium abscessus subsp. abscessus (MAB) is a highly drug resistant mycobacterium and the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria. MAB is also one of the most deadly of the emerging cystic fibrosis (CF) pathogens requiring prolonged tr...

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Veröffentlicht in:	BMC genomics Jg. 17; H. 1; S. 553
Hauptverfasser:	Miranda-CasoLuengo, Aleksandra A., Staunton, Patrick M., Dinan, Adam M., Lohan, Amanda J., Loftus, Brendan J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 05.08.2016 BioMed Central Ltd
Schlagworte:	Adaptation, Biological - genetics Animal Genetics and Genomics Anti-Bacterial Agents - pharmacology Antibiotics Biomedical and Life Sciences Care and treatment Cystic fibrosis Dosage and administration Drug Resistance, Bacterial Evolution, Molecular Fatty Acids - metabolism Gene Expression Profiling Gene Expression Regulation, Bacterial Genetic aspects Genetic transcription Genome, Bacterial High-Throughput Nucleotide Sequencing Host-Pathogen Interactions Hypoxia Iron - metabolism Life Sciences Microarrays Microbial Genetics and Genomics Mycobacteria Mycobacterium Mycobacterium - genetics Mycobacterium - metabolism Open Reading Frames Physiological aspects Plant Genetics and Genomics Prokaryote microbial genomics Protein Isoforms Proteomics Research Article Risk factors RNA, Bacterial Siderophores - biosynthesis Stress, Physiological - genetics Transcriptome Cystic fibrosis Antibiotic Integrated map WhiB7 Mycobacterium abscessus
ISSN:	1471-2164, 1471-2164
Online-Zugang:	Volltext
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