Removing batch effects from purified plasma cell gene expression microarrays with modified ComBat

Background Gene expression profiling (GEP) via microarray analysis is a widely used tool for assessing risk and other patient diagnostics in clinical settings. However, non-biological factors such as systematic changes in sample preparation, differences in scanners, and other potential batch effects...

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Veröffentlicht in:	BMC bioinformatics Jg. 16; H. 1; S. 63
Hauptverfasser:	Stein, Caleb K, Qu, Pingping, Epstein, Joshua, Buros, Amy, Rosenthal, Adam, Crowley, John, Morgan, Gareth, Barlogie, Bart
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 25.02.2015 BioMed Central Ltd
Schlagworte:	Algorithms Analysis Bioinformatics Biomedical and Life Sciences Bone Marrow - metabolism Complications and side effects Computational Biology/Bioinformatics Computer Appl. in Life Sciences Data Interpretation, Statistical Gene expression Gene Expression Profiling - standards Humans Life Sciences Medical research Medicine, Experimental Methodology Methodology Article Microarray Analysis - methods Microarrays Multiple myeloma Plasma Cells - metabolism Transcriptome analysis M-ComBat ComBat Gene expression profiling (GEP) Batch effect Microarray analysis Meta-analysis Multiple myeloma (MM)
ISSN:	1471-2105, 1471-2105
Online-Zugang:	Volltext
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