Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application

Raloxifene hydrochloride, a highly effective drug for the treatment of invasive breast cancer and osteoporosis in post-menopausal women, shows poor oral bioavailability of 2%. The aim of this study was to develop, statistically optimize, and characterize raloxifene hydrochloride-loaded transfersomes...

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Bibliographic Details
Published in:	International journal of nanomedicine Vol. 9; no. Issue 1; pp. 4331 - 4346
Main Authors:	Mandal, Uttam, Mahmood, Syed, Taher, Muhammad
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01.01.2014 Taylor & Francis Ltd Dove Press Dove Medical Press
Subjects:	Administration, Cutaneous Animals Bioavailability Bone density Box-Behnken Breast cancer Cancer therapies Complications and side effects Dosage and administration Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Carriers - pharmacology Drug delivery systems Drug dosages Drugs Fourier transforms Fractures Hormone replacement therapy Lipids Metabolism Models, Biological Nanoparticles Nanostructures - chemistry Original Research Osteoporosis Particle Size Pharmacy Phospholipids Properties Raloxifene raloxifene hydrochloride Raloxifene Hydrochloride - chemistry Raloxifene Hydrochloride - pharmacokinetics Rats Rats, Wistar Reproducibility of Results Research Design RSM Skin - chemistry Skin Absorption - drug effects Surface-Active Agents Surfactants transdermal flux Transdermal medication transfersomes Vehicles Womens health Malaysia United States > US Germany Box-Behnken transfersomes RSM raloxifene hydrochloride transdermal flux
ISSN:	1178-2013, 1176-9114, 1178-2013
Online Access:	Get full text
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