The essential kinase ATR: ensuring faithful duplication of a challenging genome

Key Points Ataxia telangiectasia and Rad3-related (ATR) is an essential kinase that is active in S phase, senses stressed replication forks and orchestrates a multifaceted response to DNA replication stress. This response helps ensure completion of DNA replication and maintains the integrity of the...

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Bibliographic Details
Published in:	Nature reviews. Molecular cell biology Vol. 18; no. 10; pp. 622 - 636
Main Authors:	Saldivar, Joshua C., Cortez, David, Cimprich, Karlene A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2017 Nature Publishing Group
Subjects:	631/337/151 631/337/151/2356 631/337/641/2187 Animals Ataxia Ataxia telangiectasia Ataxia Telangiectasia Mutated Proteins - metabolism Biochemistry Cancer Research Cell Biology Cell cycle Cellular signal transduction Control stability Deoxyribonucleic acid Developmental Biology DNA DNA Replication Eukaryota - metabolism Gene amplification Genetic aspects Genetic research Genome Genome, Human Genomes Health aspects Humans Kinases Life Sciences Phosphotransferases Replication Replication forks Replication origins Reproduction (copying) review-article Signal Transduction Signaling Stem Cells
ISSN:	1471-0072, 1471-0080, 1471-0080
Online Access:	Get full text
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