Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

Jessica Zucman-Rossi and colleagues identify clonal integrations of adeno-associated virus type 2 (AAV2) in hepatocellular carcinomas. These AAV2 integrations occurred within known cancer driver genes, suggesting a pathogenic role of AAV2 in these patients. Hepatocellular carcinomas (HCCs) are liver...

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Bibliographic Details
Published in:	Nature genetics Vol. 47; no. 10; pp. 1187 - 1193
Main Authors:	Nault, Jean-Charles, Datta, Shalini, Imbeaud, Sandrine, Franconi, Andrea, Mallet, Maxime, Couchy, Gabrielle, Letouzé, Eric, Pilati, Camilla, Verret, Benjamin, Blanc, Jean-Frédéric, Balabaud, Charles, Calderaro, Julien, Laurent, Alexis, Letexier, Mélanie, Bioulac-Sage, Paulette, Calvo, Fabien, Zucman-Rossi, Jessica
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2015 Nature Publishing Group
Subjects:	45 45/23 45/70 45/91 631/208/514/1948 631/337 692/699/67/1504 Agriculture Animal Genetics and Genomics Biomedicine Cancer Research Carcinoma, Hepatocellular - genetics Cell cycle Cyclin A2 - genetics Cyclin E - genetics Dependovirus - genetics Dependoviruses Development and progression Disease susceptibility Gene Function Gene mutation Genetic aspects Genomes Health aspects Hepatitis B Hepatocellular carcinoma Human Genetics Humans Identification and classification Infections Kinases letter Liver cancer Liver cirrhosis Liver Neoplasms - genetics Molecular Sequence Data Mutagenesis Mutagenesis, Insertional Mutation Oncogene Proteins - genetics Risk factors Telomerase Telomerase - genetics TNF-Related Apoptosis-Inducing Ligand - genetics Tumor necrosis factor-TNF Tumors Virus Integration Viruses
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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