DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are thought to decline in their regenerative capacity. However, HSPC function has been mostly assessed using transplantation as...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 2184 - 14
Main Authors:	Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.04.2023 Nature Publishing Group Nature Portfolio
Subjects:	13 13/31 14 38 38/77 42 45 49 49/23 49/91 59 631/250/232 631/532/2118/1542 631/532/7 64 64/110 96 Adult Aged Aging Bone Marrow Bone Marrow Cells Cell lineage Cells (biology) Cellular Biology Composition Drag Hematopoietic Stem Cells Humanities and Social Sciences Humans Immune system Life Sciences Microenvironments multidisciplinary Myeloid Cells Myelopoiesis Myelopoiesis - genetics Progenitor cells Science Science (multidisciplinary) Subcellular Processes Tracing Transcriptomics Transplantation barcoding ageing hematopoiesis single cell clonality lineage tracing
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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