The landscape of somatic mutation in normal colorectal epithelial cells

The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer 1 . However, our understanding of the earliest phases of colorectal neoplastic changes—which may occur in morp...

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Bibliographic Details
Published in:	Nature (London) Vol. 574; no. 7779; pp. 532 - 537
Main Authors:	Lee-Six, Henry, Olafsson, Sigurgeir, Ellis, Peter, Osborne, Robert J., Sanders, Mathijs A., Moore, Luiza, Georgakopoulos, Nikitas, Torrente, Franco, Noorani, Ayesha, Goddard, Martin, Robinson, Philip, Coorens, Tim H. H., O’Neill, Laura, Alder, Christopher, Wang, Jingwei, Fitzgerald, Rebecca C., Zilbauer, Matthias, Coleman, Nicholas, Saeb-Parsy, Kourosh, Martincorena, Inigo, Campbell, Peter J., Stratton, Michael R.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2019 Nature Publishing Group
Subjects:	45/100 45/22 45/23 45/41 631/532/2437 631/67/1504/1885/1393 631/67/69 Adenoma - genetics Adenoma - pathology Aged Axin Protein - genetics Carcinoma - genetics Carcinoma - pathology Cell Transformation, Neoplastic Clone Cells - cytology Clone Cells - metabolism Colon (Anatomy) Colon - cytology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Copy Number Variations DNA Mutational Analysis Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Female Genetic aspects Humanities and Social Sciences Humans Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Middle Aged multidisciplinary Mutation Mutation (Biology) Physiological aspects Prodromal Symptoms Rectum Rectum - cytology Science Science (multidisciplinary) Stem Cells - cytology Stem Cells - metabolism United Kingdom
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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