Convergence of congenic mapping and allele-specific alterations in tumors for the resolution of the Skts1 skin tumor susceptibility locus

Although several familial cancer genes with high-penetrance mutations have been identified, the major genetic component of susceptibility to sporadic cancers is attributable to low-penetrance alleles. These ‘weak’ tumor susceptibility genes do not segregate as single Mendelian traits and are therefo...

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Bibliographic Details
Published in:	Oncogene Vol. 26; no. 28; pp. 4171 - 4178
Main Authors:	de Koning, J P, Wakabayashi, Y, Nagase, H, Mao, J-H, Balmain, A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.06.2007 Nature Publishing Nature Publishing Group
Subjects:	Alleles Analysis Animal models Animals Apoptosis Biological and medical sciences Cancer Cell Biology Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Chromosome 7 Chromosome mapping Chromosomes Fundamental and applied biological sciences. Psychology Gene expression Gene mapping Genetic analysis Genetic aspects Genetic diversity Genetic Predisposition to Disease Health aspects Human Genetics In Situ Hybridization, Fluorescence Internal Medicine Linkage analysis Medicine Medicine & Public Health Methods Molecular and cellular biology Molecular biology Mutation Oncogenes oncogenomics Oncology Population studies Recombination Risk factors Skin cancer Skin Neoplasms - genetics Skin tumors Susceptibility Tumors United States congenic skin susceptibility LOH allele-specific papilloma Allele Sensitivity Loss of heterozygosity Papilloma Congenic Skin Benign neoplasm Carcinogenesis
ISSN:	0950-9232, 1476-5594
Online Access:	Get full text
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