The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan
Physicochemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every biological process, at all levels, from small molecules to cells. The damage is too numerous to be repaired, is partially invisible to natur...
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| Vydáno v: | Trends in genetics Ročník 29; číslo 9; s. 506 - 512 |
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| Hlavní autor: | |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Elsevier Ltd
01.09.2013
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| ISSN: | 0168-9525 |
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| Abstract | Physicochemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every biological process, at all levels, from small molecules to cells. The damage is too numerous to be repaired, is partially invisible to natural selection, and manifests as aging. I propose that the inherent imperfectness of biological systems is the true root of the aging process. Because each biomolecule generates specific forms of damage, the cumulative damage is largely non-random and is indirectly encoded in the genome. I consider this concept in light of other proposed theories of aging and integrate these disparate ideas into a single model. I also discuss the evolutionary significance of damage accumulation and strategies for reducing damage. Finally, I suggest ways to test this integrated model of aging. |
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| AbstractList | Physicochemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every biological process, at all levels, from small molecules to cells. The damage is too numerous to be repaired, is partially invisible to natural selection, and manifests as aging. I propose that the inherent imperfectness of biological systems is the true root of the aging process. Because each biomolecule generates specific forms of damage, the cumulative damage is largely non-random and is indirectly encoded in the genome. I consider this concept in light of other proposed theories of aging and integrate these disparate ideas into a single model. I also discuss the evolutionary significance of damage accumulation and strategies for reducing damage. Finally, I suggest ways to test this integrated model of aging. Physicochemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every biological process, at all levels, from small molecules to cells. The damage is too numerous to be repaired, is partially invisible to natural selection, and manifests as aging. I propose that the inherent imperfectness of biological systems is the true root of the aging process. Because each biomolecule generates specific forms of damage, the cumulative damage is largely non-random and is indirectly encoded in the genome. I consider this concept in light of other proposed theories of aging and integrate these disparate ideas into a single model. I also discuss the evolutionary significance of damage accumulation and strategies for reducing damage. Finally, I suggest ways to test this integrated model of aging.Physicochemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every biological process, at all levels, from small molecules to cells. The damage is too numerous to be repaired, is partially invisible to natural selection, and manifests as aging. I propose that the inherent imperfectness of biological systems is the true root of the aging process. Because each biomolecule generates specific forms of damage, the cumulative damage is largely non-random and is indirectly encoded in the genome. I consider this concept in light of other proposed theories of aging and integrate these disparate ideas into a single model. I also discuss the evolutionary significance of damage accumulation and strategies for reducing damage. Finally, I suggest ways to test this integrated model of aging. Physico-chemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every biological process, at all levels, from small molecules to cells. The damage is too numerous to be repaired, is partially invisible to natural selection and manifests as aging. I propose that it is the inherent imperfectness of biological systems that is the true root of the aging process. As each biomolecule generates specific forms of damage, the cumulative damage is largely non-random and is indirectly encoded in the genome. I consider this concept in light of other proposed theories of aging and integrate these disparate ideas into a single model. I also discuss the evolutionary significance of damage accumulation and strategies for reducing damage. Finally, I suggest ways to test this integrated model of aging. |
| Author | Gladyshev, Vadim N. |
| Author_xml | – sequence: 1 givenname: Vadim N. surname: Gladyshev fullname: Gladyshev, Vadim N. email: vgladyshev@rics.bwh.harvard.edu organization: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23769208$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1083/jcb.127.6.1985 10.1038/nature08221 10.1038/nchembio.441 10.1073/pnas.0307929101 10.1126/science.1083532 10.1111/j.1749-6632.1958.tb46828.x 10.1093/geronj/11.3.298 10.1096/fj.12-210872 10.1038/451644a 10.1038/nature08619 10.1016/j.cell.2012.07.023 10.1038/nature02936 10.1038/nature05985 10.4161/cc.7.21.6965 10.1038/243441a0 10.1038/270301a0 10.2307/2406060 10.1089/ars.2012.4840 10.1126/science.1411540 10.1016/0022-2836(68)90392-6 10.1038/nrg1706 10.1016/0022-5193(66)90184-6 10.4161/cc.9.10.11872 10.1038/nature11331 10.1038/nature00829 10.1007/BF00569695 10.1038/nature07216 10.1002/bies.201200092 10.1002/bies.201100189 10.1038/35041682 10.1093/gerona/62.2.149 |
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| References | Kirkwood (bib0090) 1977; 270 Failla (bib0120) 1958; 71 Kirkwood (bib0105) 2008; 451 Hamilton (bib0085) 1966; 12 Gladyshev (bib0035) 2012; 34 Grandison (bib0100) 2009; 462 Ackermann (bib0155) 2003; 300 Crick (bib0040) 1968; 38 Muller (bib0165) 2012; 488 Reznick (bib0095) 2004; 431 Ackerman, Gems (bib0055) 2012; 34 Harman (bib0110) 1956; 11 Kennedy (bib0130) 1994; 127 Carey (bib0150) 1992; 258 Longo (bib0050) 2005; 6 Blagosklonny (bib0020) 2008; 7 Williams (bib0080) 1957; 11 Vijg (bib0175) 2007 Vijg, Campisi (bib0010) 2008; 454 Tawfik (bib0025) 2010; 6 de Magalhães (bib0135) 2007; 62 Kirkwood, Cremer (bib0045) 1982; 60 Medawar (bib0075) 1952 Gems, de la Guardia (bib0060) 2013 Blagosklonny (bib0070) 2010; 9 Nijhawan (bib0170) 2012; 150 de Magalhaes (bib0065) 2012; 26 Koc (bib0115) 2004; 101 Finkel (bib0160) 2007; 448 Lin (bib0140) 2002; 418 Weng, Noel (bib0030) 2013 Harrison (bib0145) 2009; 460 Kirkwood, Austad (bib0005) 2000; 408 Orgel (bib0015) 1973; 243 Hamilton (10.1016/j.tig.2013.05.004_bib0085) 1966; 12 Harman (10.1016/j.tig.2013.05.004_bib0110) 1956; 11 Ackermann (10.1016/j.tig.2013.05.004_bib0155) 2003; 300 Williams (10.1016/j.tig.2013.05.004_bib0080) 1957; 11 Harrison (10.1016/j.tig.2013.05.004_bib0145) 2009; 460 Carey (10.1016/j.tig.2013.05.004_bib0150) 1992; 258 Kirkwood (10.1016/j.tig.2013.05.004_bib0105) 2008; 451 Crick (10.1016/j.tig.2013.05.004_bib0040) 1968; 38 Gems (10.1016/j.tig.2013.05.004_bib0060) 2013 Nijhawan (10.1016/j.tig.2013.05.004_bib0170) 2012; 150 Grandison (10.1016/j.tig.2013.05.004_bib0100) 2009; 462 Kennedy (10.1016/j.tig.2013.05.004_bib0130) 1994; 127 Blagosklonny (10.1016/j.tig.2013.05.004_bib0020) 2008; 7 de Magalhaes (10.1016/j.tig.2013.05.004_bib0065) 2012; 26 Medawar (10.1016/j.tig.2013.05.004_bib0075) 1952 Gladyshev (10.1016/j.tig.2013.05.004_bib0035) 2012; 34 Longo (10.1016/j.tig.2013.05.004_bib0050) 2005; 6 Weng (10.1016/j.tig.2013.05.004_bib0030) 2013 Reznick (10.1016/j.tig.2013.05.004_bib0095) 2004; 431 Failla (10.1016/j.tig.2013.05.004_bib0120) 1958; 71 Lin (10.1016/j.tig.2013.05.004_bib0140) 2002; 418 Tawfik (10.1016/j.tig.2013.05.004_bib0025) 2010; 6 Koc (10.1016/j.tig.2013.05.004_bib0115) 2004; 101 Ackerman (10.1016/j.tig.2013.05.004_bib0055) 2012; 34 Vijg (10.1016/j.tig.2013.05.004_bib0175) 2007 Kirkwood (10.1016/j.tig.2013.05.004_bib0045) 1982; 60 de Magalhães (10.1016/j.tig.2013.05.004_bib0135) 2007; 62 Vijg (10.1016/j.tig.2013.05.004_bib0010) 2008; 454 Muller (10.1016/j.tig.2013.05.004_bib0165) 2012; 488 Blagosklonny (10.1016/j.tig.2013.05.004_bib0070) 2010; 9 Kirkwood (10.1016/j.tig.2013.05.004_bib0090) 1977; 270 Orgel (10.1016/j.tig.2013.05.004_bib0015) 1973; 243 Finkel (10.1016/j.tig.2013.05.004_bib0160) 2007; 448 Kirkwood (10.1016/j.tig.2013.05.004_bib0005) 2000; 408 1411540 - Science. 1992 Oct 16;258(5081):457-61 23269558 - Cold Spring Harb Symp Quant Biol. 2012;77:309-20 7042533 - Hum Genet. 1982;60(2):101-21 12817142 - Science. 2003 Jun 20;300(5627):1920 6015424 - J Theor Biol. 1966 Sep;12(1):12-45 4887876 - J Mol Biol. 1968 Dec;38(3):367-79 11089980 - Nature. 2000 Nov 9;408(6809):233-8 15141092 - Proc Natl Acad Sci U S A. 2004 May 25;101(21):7999-8004 20436272 - Cell Cycle. 2010 May 15;9(10):1859-62 18256658 - Nature. 2008 Feb 7;451(7179):644-7 22371137 - Bioessays. 2012 Jun;34(6):466-71 22870907 - Antioxid Redox Signal. 2013 Jul 20;19(3):321-9 15510147 - Nature. 2004 Oct 28;431(7012):1095-9 22915358 - Bioessays. 2012 Nov;34(11):925-9 19587680 - Nature. 2009 Jul 16;460(7253):392-5 13332224 - J Gerontol. 1956 Jul;11(3):298-300 12124627 - Nature. 2002 Jul 18;418(6895):344-8 593350 - Nature. 1977 Nov 24;270(5635):301-4 20852602 - Nat Chem Biol. 2010 Oct;6(10):692-6 17339640 - J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):149-60 16304601 - Nat Rev Genet. 2005 Nov;6(11):866-72 17700693 - Nature. 2007 Aug 16;448(7155):767-74 22895339 - Nature. 2012 Aug 16;488(7411):337-42 4591306 - Nature. 1973 Jun 22;243(5408):441-5 22964300 - FASEB J. 2012 Dec;26(12):4821-6 18756247 - Nature. 2008 Aug 28;454(7208):1065-71 18971624 - Cell Cycle. 2008 Nov 1;7(21):3344-54 13583876 - Ann N Y Acad Sci. 1958 Sep 30;71(6):1124-40 19956092 - Nature. 2009 Dec 24;462(7276):1061-4 22901813 - Cell. 2012 Aug 17;150(4):842-54 7806576 - J Cell Biol. 1994 Dec;127(6 Pt 2):1985-93 |
| References_xml | – volume: 258 start-page: 457 year: 1992 end-page: 461 ident: bib0150 article-title: Slowing of mortality rates at older ages in large medfly cohorts publication-title: Science – volume: 11 start-page: 298 year: 1956 end-page: 300 ident: bib0110 article-title: Aging: a theory based on free radical and radiation chemistry publication-title: J. Gerontol. – volume: 448 start-page: 767 year: 2007 end-page: 774 ident: bib0160 article-title: The common biology of cancer and ageing publication-title: Nature – volume: 488 start-page: 337 year: 2012 end-page: 342 ident: bib0165 article-title: Passenger deletions generate therapeutic vulnerabilities in cancer publication-title: Nature – volume: 451 start-page: 644 year: 2008 end-page: 647 ident: bib0105 article-title: A systematic look at an old problem publication-title: Nature – year: 2013 ident: bib0060 article-title: Alternative perspectives on aging in publication-title: Antioxid. Redox Signal. – year: 1952 ident: bib0075 article-title: An Unsolved Problem of Biology – year: 2007 ident: bib0175 article-title: Aging of the genome publication-title: The Dual Role of DNA in Life and Death – volume: 26 start-page: 4821 year: 2012 end-page: 4826 ident: bib0065 article-title: Programmatic features of aging originating in development: aging mechanisms beyond molecular damage? publication-title: FASEB J. – volume: 270 start-page: 301 year: 1977 end-page: 304 ident: bib0090 article-title: Evolution of ageing publication-title: Nature – volume: 462 start-page: 1061 year: 2009 end-page: 1064 ident: bib0100 article-title: Amino-acid imbalance explains extension of lifespan by dietary restriction in publication-title: Nature – volume: 431 start-page: 1095 year: 2004 end-page: 1099 ident: bib0095 article-title: Effect of extrinsic mortality on the evolution of senescence in guppies publication-title: Nature – volume: 9 start-page: 1859 year: 2010 end-page: 1862 ident: bib0070 article-title: Rapamycin and quasi-programmed aging: four years later publication-title: Cell Cycle – volume: 243 start-page: 441 year: 1973 end-page: 445 ident: bib0015 article-title: Ageing of clones of mammalian cells publication-title: Nature – volume: 34 start-page: 466 year: 2012 end-page: 471 ident: bib0055 article-title: The mystery of publication-title: Bioessays – volume: 300 start-page: 1920 year: 2003 ident: bib0155 article-title: Senescence in a bacterium with asymmetric division publication-title: Science – volume: 454 start-page: 1065 year: 2008 end-page: 1071 ident: bib0010 article-title: Puzzles, promises and a cure for ageing publication-title: Nature – volume: 408 start-page: 233 year: 2000 end-page: 238 ident: bib0005 article-title: Why do we age? publication-title: Nature – volume: 6 start-page: 692 year: 2010 end-page: 696 ident: bib0025 article-title: Messy biology and the origins of evolutionary innovations publication-title: Nat. Chem. Biol. – volume: 127 start-page: 1985 year: 1994 end-page: 1993 ident: bib0130 article-title: Daughter cells of publication-title: J. Cell Biol. – volume: 150 start-page: 842 year: 2012 end-page: 854 ident: bib0170 article-title: Cancer vulnerabilities unveiled by genomic loss publication-title: Cell – year: 2013 ident: bib0030 article-title: The remarkable pliability and promiscuity of specialized metabolism publication-title: Cold Spring Harb. Symp. Quant. Biol. – volume: 11 start-page: 398 year: 1957 end-page: 411 ident: bib0080 article-title: Pleiotropy, natural selection, and the evolution of senescence publication-title: Evolution – volume: 62 start-page: 149 year: 2007 end-page: 160 ident: bib0135 article-title: An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts publication-title: J. Gerontol. A: Biol. Sci. Med. Sci. – volume: 12 start-page: 12 year: 1966 end-page: 45 ident: bib0085 article-title: The moulding of senescence by natural selection publication-title: J. Theor. Biol. – volume: 7 start-page: 3344 year: 2008 end-page: 3354 ident: bib0020 article-title: Aging: ROS or TOR publication-title: Cell Cycle – volume: 418 start-page: 344 year: 2002 end-page: 348 ident: bib0140 article-title: Calorie restriction extends publication-title: Nature – volume: 71 start-page: 1124 year: 1958 end-page: 1140 ident: bib0120 article-title: The aging process and cancerogenesis publication-title: Ann. N. Y. Acad. Sci. – volume: 38 start-page: 367 year: 1968 end-page: 379 ident: bib0040 article-title: The origin of the genetic code publication-title: J. Mol. Biol. – volume: 60 start-page: 101 year: 1982 end-page: 121 ident: bib0045 article-title: Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress publication-title: Hum. Genet. – volume: 6 start-page: 866 year: 2005 end-page: 872 ident: bib0050 article-title: Programmed and altruistic ageing publication-title: Nat. Rev. Genet. – volume: 460 start-page: 392 year: 2009 end-page: 395 ident: bib0145 article-title: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice publication-title: Nature – volume: 34 start-page: 925 year: 2012 end-page: 929 ident: bib0035 article-title: On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan publication-title: Bioessays – volume: 101 start-page: 7999 year: 2004 end-page: 8004 ident: bib0115 article-title: Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 127 start-page: 1985 year: 1994 ident: 10.1016/j.tig.2013.05.004_bib0130 article-title: Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span publication-title: J. Cell Biol. doi: 10.1083/jcb.127.6.1985 – volume: 460 start-page: 392 year: 2009 ident: 10.1016/j.tig.2013.05.004_bib0145 article-title: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice publication-title: Nature doi: 10.1038/nature08221 – volume: 6 start-page: 692 year: 2010 ident: 10.1016/j.tig.2013.05.004_bib0025 article-title: Messy biology and the origins of evolutionary innovations publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.441 – volume: 101 start-page: 7999 year: 2004 ident: 10.1016/j.tig.2013.05.004_bib0115 article-title: Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0307929101 – volume: 300 start-page: 1920 year: 2003 ident: 10.1016/j.tig.2013.05.004_bib0155 article-title: Senescence in a bacterium with asymmetric division publication-title: Science doi: 10.1126/science.1083532 – volume: 71 start-page: 1124 year: 1958 ident: 10.1016/j.tig.2013.05.004_bib0120 article-title: The aging process and cancerogenesis publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1958.tb46828.x – volume: 11 start-page: 298 year: 1956 ident: 10.1016/j.tig.2013.05.004_bib0110 article-title: Aging: a theory based on free radical and radiation chemistry publication-title: J. Gerontol. doi: 10.1093/geronj/11.3.298 – volume: 26 start-page: 4821 year: 2012 ident: 10.1016/j.tig.2013.05.004_bib0065 article-title: Programmatic features of aging originating in development: aging mechanisms beyond molecular damage? publication-title: FASEB J. doi: 10.1096/fj.12-210872 – volume: 451 start-page: 644 year: 2008 ident: 10.1016/j.tig.2013.05.004_bib0105 article-title: A systematic look at an old problem publication-title: Nature doi: 10.1038/451644a – year: 2007 ident: 10.1016/j.tig.2013.05.004_bib0175 article-title: Aging of the genome – volume: 462 start-page: 1061 year: 2009 ident: 10.1016/j.tig.2013.05.004_bib0100 article-title: Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila publication-title: Nature doi: 10.1038/nature08619 – volume: 150 start-page: 842 year: 2012 ident: 10.1016/j.tig.2013.05.004_bib0170 article-title: Cancer vulnerabilities unveiled by genomic loss publication-title: Cell doi: 10.1016/j.cell.2012.07.023 – volume: 431 start-page: 1095 year: 2004 ident: 10.1016/j.tig.2013.05.004_bib0095 article-title: Effect of extrinsic mortality on the evolution of senescence in guppies publication-title: Nature doi: 10.1038/nature02936 – volume: 448 start-page: 767 year: 2007 ident: 10.1016/j.tig.2013.05.004_bib0160 article-title: The common biology of cancer and ageing publication-title: Nature doi: 10.1038/nature05985 – volume: 7 start-page: 3344 year: 2008 ident: 10.1016/j.tig.2013.05.004_bib0020 article-title: Aging: ROS or TOR publication-title: Cell Cycle doi: 10.4161/cc.7.21.6965 – volume: 243 start-page: 441 year: 1973 ident: 10.1016/j.tig.2013.05.004_bib0015 article-title: Ageing of clones of mammalian cells publication-title: Nature doi: 10.1038/243441a0 – year: 2013 ident: 10.1016/j.tig.2013.05.004_bib0030 article-title: The remarkable pliability and promiscuity of specialized metabolism publication-title: Cold Spring Harb. Symp. Quant. Biol. – volume: 270 start-page: 301 year: 1977 ident: 10.1016/j.tig.2013.05.004_bib0090 article-title: Evolution of ageing publication-title: Nature doi: 10.1038/270301a0 – volume: 11 start-page: 398 year: 1957 ident: 10.1016/j.tig.2013.05.004_bib0080 article-title: Pleiotropy, natural selection, and the evolution of senescence publication-title: Evolution doi: 10.2307/2406060 – year: 2013 ident: 10.1016/j.tig.2013.05.004_bib0060 article-title: Alternative perspectives on aging in C. elegans: reactive oxygen species or hyperfunction? publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2012.4840 – volume: 258 start-page: 457 year: 1992 ident: 10.1016/j.tig.2013.05.004_bib0150 article-title: Slowing of mortality rates at older ages in large medfly cohorts publication-title: Science doi: 10.1126/science.1411540 – volume: 38 start-page: 367 year: 1968 ident: 10.1016/j.tig.2013.05.004_bib0040 article-title: The origin of the genetic code publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(68)90392-6 – volume: 6 start-page: 866 year: 2005 ident: 10.1016/j.tig.2013.05.004_bib0050 article-title: Programmed and altruistic ageing publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1706 – volume: 12 start-page: 12 year: 1966 ident: 10.1016/j.tig.2013.05.004_bib0085 article-title: The moulding of senescence by natural selection publication-title: J. Theor. Biol. doi: 10.1016/0022-5193(66)90184-6 – volume: 9 start-page: 1859 year: 2010 ident: 10.1016/j.tig.2013.05.004_bib0070 article-title: Rapamycin and quasi-programmed aging: four years later publication-title: Cell Cycle doi: 10.4161/cc.9.10.11872 – volume: 488 start-page: 337 year: 2012 ident: 10.1016/j.tig.2013.05.004_bib0165 article-title: Passenger deletions generate therapeutic vulnerabilities in cancer publication-title: Nature doi: 10.1038/nature11331 – volume: 418 start-page: 344 year: 2002 ident: 10.1016/j.tig.2013.05.004_bib0140 article-title: Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration publication-title: Nature doi: 10.1038/nature00829 – volume: 60 start-page: 101 year: 1982 ident: 10.1016/j.tig.2013.05.004_bib0045 article-title: Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress publication-title: Hum. Genet. doi: 10.1007/BF00569695 – volume: 454 start-page: 1065 year: 2008 ident: 10.1016/j.tig.2013.05.004_bib0010 article-title: Puzzles, promises and a cure for ageing publication-title: Nature doi: 10.1038/nature07216 – volume: 34 start-page: 925 year: 2012 ident: 10.1016/j.tig.2013.05.004_bib0035 article-title: On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan publication-title: Bioessays doi: 10.1002/bies.201200092 – volume: 34 start-page: 466 year: 2012 ident: 10.1016/j.tig.2013.05.004_bib0055 article-title: The mystery of C. elegans aging: An emerging role for fat: Distant parallels between C. elegans aging and metabolic syndrome? publication-title: Bioessays doi: 10.1002/bies.201100189 – volume: 408 start-page: 233 year: 2000 ident: 10.1016/j.tig.2013.05.004_bib0005 article-title: Why do we age? publication-title: Nature doi: 10.1038/35041682 – year: 1952 ident: 10.1016/j.tig.2013.05.004_bib0075 – volume: 62 start-page: 149 year: 2007 ident: 10.1016/j.tig.2013.05.004_bib0135 article-title: An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts publication-title: J. Gerontol. A: Biol. Sci. Med. Sci. doi: 10.1093/gerona/62.2.149 – reference: 1411540 - Science. 1992 Oct 16;258(5081):457-61 – reference: 19587680 - Nature. 2009 Jul 16;460(7253):392-5 – reference: 4887876 - J Mol Biol. 1968 Dec;38(3):367-79 – reference: 20852602 - Nat Chem Biol. 2010 Oct;6(10):692-6 – reference: 18756247 - Nature. 2008 Aug 28;454(7208):1065-71 – reference: 23269558 - Cold Spring Harb Symp Quant Biol. 2012;77:309-20 – reference: 18971624 - Cell Cycle. 2008 Nov 1;7(21):3344-54 – reference: 6015424 - J Theor Biol. 1966 Sep;12(1):12-45 – reference: 22915358 - Bioessays. 2012 Nov;34(11):925-9 – reference: 19956092 - Nature. 2009 Dec 24;462(7276):1061-4 – reference: 22371137 - Bioessays. 2012 Jun;34(6):466-71 – reference: 7806576 - J Cell Biol. 1994 Dec;127(6 Pt 2):1985-93 – reference: 20436272 - Cell Cycle. 2010 May 15;9(10):1859-62 – reference: 12124627 - Nature. 2002 Jul 18;418(6895):344-8 – reference: 22870907 - Antioxid Redox Signal. 2013 Jul 20;19(3):321-9 – reference: 15141092 - Proc Natl Acad Sci U S A. 2004 May 25;101(21):7999-8004 – reference: 15510147 - Nature. 2004 Oct 28;431(7012):1095-9 – reference: 593350 - Nature. 1977 Nov 24;270(5635):301-4 – reference: 22901813 - Cell. 2012 Aug 17;150(4):842-54 – reference: 17700693 - Nature. 2007 Aug 16;448(7155):767-74 – reference: 4591306 - Nature. 1973 Jun 22;243(5408):441-5 – reference: 12817142 - Science. 2003 Jun 20;300(5627):1920 – reference: 18256658 - Nature. 2008 Feb 7;451(7179):644-7 – reference: 22895339 - Nature. 2012 Aug 16;488(7411):337-42 – reference: 13332224 - J Gerontol. 1956 Jul;11(3):298-300 – reference: 17339640 - J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):149-60 – reference: 22964300 - FASEB J. 2012 Dec;26(12):4821-6 – reference: 7042533 - Hum Genet. 1982;60(2):101-21 – reference: 13583876 - Ann N Y Acad Sci. 1958 Sep 30;71(6):1124-40 – reference: 11089980 - Nature. 2000 Nov 9;408(6809):233-8 – reference: 16304601 - Nat Rev Genet. 2005 Nov;6(11):866-72 |
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| SubjectTerms | Aging - genetics Aging - physiology biochemical compounds Biological Evolution DNA Damage - physiology genome Genome, Human Humans longevity Longevity - physiology Medical Education Models, Biological natural selection Oxidative Stress - genetics physicochemical properties process control Selection, Genetic |
| Title | The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan |
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