Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations

Alzheimer disease (AD) is the most common form of senile dementia, with high incidence late in life in many populations including Caribbean Hispanic (CH) populations. Such admixed populations, descended from more than one ancestral population, can present challenges for genetic studies, including li...

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Bibliographic Details
Published in:	HGG advances Vol. 4; no. 3; p. 100207
Main Authors:	Horimoto, Andrea R.V.R., Boyken, Lisa A., Blue, Elizabeth E., Grinde, Kelsey E., Nafikov, Rafael A., Sohi, Harkirat K., Nato, Alejandro Q., Bis, Joshua C., Brusco, Luis I., Morelli, Laura, Ramirez, Alfredo, Dalmasso, Maria Carolina, Temple, Seth, Satizabal, Claudia, Browning, Sharon R., Seshadri, Sudha, Wijsman, Ellen M., Thornton, Timothy A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 13.07.2023 Elsevier
Subjects:	Alzheimer disease Alzheimer Disease - genetics ancestry Argentina Caribbean Ethnicity gene mapping Genetic Loci - genetics genetic variation Genetics Genome-Wide Association Study genomics haplotype haplotypes Hispanic or Latino - genetics human genetics Humans Latinos local ancestry loci multi-ethnic non-coding population structure protective rare variation risk risk reduction statistical models whole genome sequence Caribbean Argentina haplotype population structure local ancestry non-coding gene mapping whole genome sequence protective multi-ethnic rare variation
ISSN:	2666-2477, 2666-2477
Online Access:	Get full text
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