Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small mole...

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Published in:Nature (London) Vol. 514; no. 7523; pp. 513 - 517
Main Authors: Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Welstead, G. Grant, Trimarchi, Thomas, Bakogianni, Sofia, Xu, Luyao, Loizou, Evangelia, Holmfeldt, Linda, Strikoudis, Alexandros, King, Bryan, Mullenders, Jasper, Becksfort, Jared, Nedjic, Jelena, Paietta, Elisabeth, Tallman, Martin S., Rowe, Jacob M., Tonon, Giovanni, Satoh, Takashi, Kruidenier, Laurens, Prinjha, Rab, Akira, Shizuo, Van Vlierberghe, Pieter, Ferrando, Adolfo A., Jaenisch, Rudolf, Mullighan, Charles G., Aifantis, Iannis
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 23.10.2014
Nature Publishing Group
Subjects:
13/31
38
38/23
38/39
45
45/15
45/91
59/5
631/337/100/2285
631/67/1990/283
Animals
Benzazepines - pharmacology
Binding sites
Epigenesis, Genetic - drug effects
Genes
Genetic aspects
Genomes
Health aspects
Histone Demethylases - genetics
Histone Demethylases - metabolism
Histones
Histones - chemistry
Histones - metabolism
Humanities and Social Sciences
Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors
Jumonji Domain-Containing Histone Demethylases - metabolism
letter
Leukemia
Lymphocytic leukemia
Lysine
Lysine - metabolism
Methylation - drug effects
Methyltransferases
Mice
multidisciplinary
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Proteins
Pyrimidines - pharmacology
Science
Studies
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
ISSN:0028-0836, 1476-4687, 1476-4687
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Abstract T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small molecule demethylase inhibitor is found to inhibit the growth of T-ALL cell lines, introducing a potential therapeutic avenue for acute leukaemia. Targeting acute lymphoblastic leukaemia Two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown here to have contrasting roles in human T-cell acute lymphoblastic leukaemia (T-ALL) cells and a mouse model of the disease. JMJD3 is overexpressed in T-ALL and essential for initiation and maintenance of disease, whereas UTX is a target of inactivating mutations in human T-ALL and acts a tumour suppressor. A small-molecule demethylase inhibitor inhibits the growth of T-ALL cell lines, introducing a potential therapeutic avenue for an acute leukemia that has a poor prognosis and no currently available targeted therapies. T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders 1 , and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified 2 , 3 ; however, ‘epigenetic’ drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL 4 . Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5 ) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
AbstractList T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders, and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified; however, 'epigenetic' drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL. Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders (1), and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified (2,3); however, 'epigenetic' drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL4. Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small molecule demethylase inhibitor is found to inhibit the growth of T-ALL cell lines, introducing a potential therapeutic avenue for acute leukaemia. Targeting acute lymphoblastic leukaemia Two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown here to have contrasting roles in human T-cell acute lymphoblastic leukaemia (T-ALL) cells and a mouse model of the disease. JMJD3 is overexpressed in T-ALL and essential for initiation and maintenance of disease, whereas UTX is a target of inactivating mutations in human T-ALL and acts a tumour suppressor. A small-molecule demethylase inhibitor inhibits the growth of T-ALL cell lines, introducing a potential therapeutic avenue for an acute leukemia that has a poor prognosis and no currently available targeted therapies. T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders 1 , and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified 2 , 3 ; however, ‘epigenetic’ drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL 4 . Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5 ) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders, and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified; however, 'epigenetic' drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL. Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders, and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified; however, 'epigenetic' drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL. Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
T cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy with dismal overall prognosis, exhibiting up to a 25% relapse rate, mainly due to the absence of non-cytotoxic targeted therapy options. Despite the fact that drugs targeting the function of key epigenetic factors have been approved in the context of hematopoietic disorders1 and the recent identification of mutations affecting chromatin modulators in a variety of leukemias2,3, “epigenetic” drugs are not currently used for TALL treatment. Recently, we described a tumor suppressor role of the polycomb repressive complex 2 (PRC2) in this tumor4. Here we sought out to delineate the role of histone 3 lysine 27 (H3K27) demethylases, JMJD3 and UTX. We show that JMJD3 is essential for initiation and maintenance of disease, as it controls important oncogenic gene targets through the modulation of H3K27 methylation. In contrast, UTX acts a tumor suppressor and frequently genetically inactivated in T-ALL. Moreover, we demonstrate that the small molecule inhibitor GSKJ45 affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with similar enzymatic function can play opposing roles in the context of the same disease and pave the way for the use of a new category of epigenetic inhibitors in hematopoietic malignancies.
Audience Academic
Author Van Vlierberghe, Pieter
Mullenders, Jasper
Rowe, Jacob M.
Nedjic, Jelena
Tallman, Martin S.
King, Bryan
Trimarchi, Thomas
Bakogianni, Sofia
Kruidenier, Laurens
Becksfort, Jared
Paietta, Elisabeth
Jaenisch, Rudolf
Ferrando, Adolfo A.
Loizou, Evangelia
Welstead, G. Grant
Mullighan, Charles G.
Satoh, Takashi
Prinjha, Rab
Xu, Luyao
Tonon, Giovanni
Ntziachristos, Panagiotis
Tsirigos, Aristotelis
Holmfeldt, Linda
Strikoudis, Alexandros
Akira, Shizuo
Aifantis, Iannis
AuthorAffiliation 1 Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York, USA
19 Department of Pediatrics, Columbia University Medical Center, New York, New York, USA
11 Technion, Israel Institute of Technology, Haifa, Israel
15 Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1Yamada-oka, Suita, Osaka 565-0871, Japan
3 Center for Health Informatics and Bioinformatics, NYU School of Medicine, New York, New York, USA
7 Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA
9 Montefiore Medical Center North, Bronx, New York, NY 10467, USA
4 Whitehead Institute for Biomedical Research, Cambridge, MA, USA
16 Epinova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline R&D, Medicines Research Centre, GunnelsWood Road, Stevenage SG1 2NY, UK
8 Department of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA
5 Department of Biology, Massachusetts Institute of Technology
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/25132549$$D View this record in MEDLINE/PubMed
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Snippet T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3...
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly...
T cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy with dismal overall prognosis, exhibiting up to a 25% relapse rate, mainly due to the...
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SubjectTerms 13/31
38
38/23
38/39
45
45/15
45/91
59/5
631/337/100/2285
631/67/1990/283
Animals
Benzazepines - pharmacology
Binding sites
Epigenesis, Genetic - drug effects
Genes
Genetic aspects
Genomes
Health aspects
Histone Demethylases - genetics
Histone Demethylases - metabolism
Histones
Histones - chemistry
Histones - metabolism
Humanities and Social Sciences
Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors
Jumonji Domain-Containing Histone Demethylases - metabolism
letter
Leukemia
Lymphocytic leukemia
Lysine
Lysine - metabolism
Methylation - drug effects
Methyltransferases
Mice
multidisciplinary
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Proteins
Pyrimidines - pharmacology
Science
Studies
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Title Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
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Volume 514
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