Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small mole...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nature (London) Ročník 514; číslo 7523; s. 513 - 517
Hlavní autoři: Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Welstead, G. Grant, Trimarchi, Thomas, Bakogianni, Sofia, Xu, Luyao, Loizou, Evangelia, Holmfeldt, Linda, Strikoudis, Alexandros, King, Bryan, Mullenders, Jasper, Becksfort, Jared, Nedjic, Jelena, Paietta, Elisabeth, Tallman, Martin S., Rowe, Jacob M., Tonon, Giovanni, Satoh, Takashi, Kruidenier, Laurens, Prinjha, Rab, Akira, Shizuo, Van Vlierberghe, Pieter, Ferrando, Adolfo A., Jaenisch, Rudolf, Mullighan, Charles G., Aifantis, Iannis
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 23.10.2014
Nature Publishing Group
Témata:
13/31
38
38/23
38/39
45
45/15
45/91
59/5
631/337/100/2285
631/67/1990/283
Animals
Benzazepines - pharmacology
Binding sites
Epigenesis, Genetic - drug effects
Genes
Genetic aspects
Genomes
Health aspects
Histone Demethylases - genetics
Histone Demethylases - metabolism
Histones
Histones - chemistry
Histones - metabolism
Humanities and Social Sciences
Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors
Jumonji Domain-Containing Histone Demethylases - metabolism
letter
Leukemia
Lymphocytic leukemia
Lysine
Lysine - metabolism
Methylation - drug effects
Methyltransferases
Mice
multidisciplinary
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Proteins
Pyrimidines - pharmacology
Science
Studies
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
ISSN:0028-0836, 1476-4687, 1476-4687
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small molecule demethylase inhibitor is found to inhibit the growth of T-ALL cell lines, introducing a potential therapeutic avenue for acute leukaemia. Targeting acute lymphoblastic leukaemia Two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown here to have contrasting roles in human T-cell acute lymphoblastic leukaemia (T-ALL) cells and a mouse model of the disease. JMJD3 is overexpressed in T-ALL and essential for initiation and maintenance of disease, whereas UTX is a target of inactivating mutations in human T-ALL and acts a tumour suppressor. A small-molecule demethylase inhibitor inhibits the growth of T-ALL cell lines, introducing a potential therapeutic avenue for an acute leukemia that has a poor prognosis and no currently available targeted therapies. T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders 1 , and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified 2 , 3 ; however, ‘epigenetic’ drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL 4 . Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5 ) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
AbstractList T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders (1), and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified (2,3); however, 'epigenetic' drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL4. Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders, and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified; however, 'epigenetic' drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL. Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small molecule demethylase inhibitor is found to inhibit the growth of T-ALL cell lines, introducing a potential therapeutic avenue for acute leukaemia. Targeting acute lymphoblastic leukaemia Two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown here to have contrasting roles in human T-cell acute lymphoblastic leukaemia (T-ALL) cells and a mouse model of the disease. JMJD3 is overexpressed in T-ALL and essential for initiation and maintenance of disease, whereas UTX is a target of inactivating mutations in human T-ALL and acts a tumour suppressor. A small-molecule demethylase inhibitor inhibits the growth of T-ALL cell lines, introducing a potential therapeutic avenue for an acute leukemia that has a poor prognosis and no currently available targeted therapies. T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders 1 , and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified 2 , 3 ; however, ‘epigenetic’ drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL 4 . Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5 ) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders, and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified; however, 'epigenetic' drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL. Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the context of haematopoietic disorders, and mutations that affect chromatin modulators in a variety of leukaemias have recently been identified; however, 'epigenetic' drugs are not currently used for T-ALL treatment. Recently, we described that the polycomb repressive complex 2 (PRC2) has a tumour-suppressor role in T-ALL. Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL. We show that JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation. By contrast, we found that UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL. Moreover, we demonstrated that the small molecule inhibitor GSKJ4 (ref. 5) affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with a similar enzymatic function can have opposing roles in the context of the same disease, paving the way for treating haematopoietic malignancies with a new category of epigenetic inhibitors.
T cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy with dismal overall prognosis, exhibiting up to a 25% relapse rate, mainly due to the absence of non-cytotoxic targeted therapy options. Despite the fact that drugs targeting the function of key epigenetic factors have been approved in the context of hematopoietic disorders1 and the recent identification of mutations affecting chromatin modulators in a variety of leukemias2,3, “epigenetic” drugs are not currently used for TALL treatment. Recently, we described a tumor suppressor role of the polycomb repressive complex 2 (PRC2) in this tumor4. Here we sought out to delineate the role of histone 3 lysine 27 (H3K27) demethylases, JMJD3 and UTX. We show that JMJD3 is essential for initiation and maintenance of disease, as it controls important oncogenic gene targets through the modulation of H3K27 methylation. In contrast, UTX acts a tumor suppressor and frequently genetically inactivated in T-ALL. Moreover, we demonstrate that the small molecule inhibitor GSKJ45 affects T-ALL growth, by targeting JMJD3 activity. These findings show that two proteins with similar enzymatic function can play opposing roles in the context of the same disease and pave the way for the use of a new category of epigenetic inhibitors in hematopoietic malignancies.
Audience Academic
Author Van Vlierberghe, Pieter
Mullenders, Jasper
Rowe, Jacob M.
Nedjic, Jelena
Tallman, Martin S.
King, Bryan
Trimarchi, Thomas
Bakogianni, Sofia
Kruidenier, Laurens
Becksfort, Jared
Paietta, Elisabeth
Jaenisch, Rudolf
Ferrando, Adolfo A.
Loizou, Evangelia
Welstead, G. Grant
Mullighan, Charles G.
Satoh, Takashi
Prinjha, Rab
Xu, Luyao
Tonon, Giovanni
Ntziachristos, Panagiotis
Tsirigos, Aristotelis
Holmfeldt, Linda
Strikoudis, Alexandros
Akira, Shizuo
Aifantis, Iannis
AuthorAffiliation 1 Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York, USA
19 Department of Pediatrics, Columbia University Medical Center, New York, New York, USA
11 Technion, Israel Institute of Technology, Haifa, Israel
15 Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1Yamada-oka, Suita, Osaka 565-0871, Japan
3 Center for Health Informatics and Bioinformatics, NYU School of Medicine, New York, New York, USA
7 Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA
9 Montefiore Medical Center North, Bronx, New York, NY 10467, USA
4 Whitehead Institute for Biomedical Research, Cambridge, MA, USA
16 Epinova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline R&D, Medicines Research Centre, GunnelsWood Road, Stevenage SG1 2NY, UK
8 Department of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA
5 Department of Biology, Massachusetts Institute of Technology
AuthorAffiliation_xml – name: 1 Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York, USA
– name: 13 Functional Genomics of Cancer Unit, Division of Molecular Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy
– name: 10 Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
– name: 16 Epinova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline R&D, Medicines Research Centre, GunnelsWood Road, Stevenage SG1 2NY, UK
– name: 11 Technion, Israel Institute of Technology, Haifa, Israel
– name: 4 Whitehead Institute for Biomedical Research, Cambridge, MA, USA
– name: 2 NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York, USA
– name: 3 Center for Health Informatics and Bioinformatics, NYU School of Medicine, New York, New York, USA
– name: 9 Montefiore Medical Center North, Bronx, New York, NY 10467, USA
– name: 6 Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA
– name: 7 Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA
– name: 17 Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
– name: 14 Laboratory of Host Defense, WPI Immunology Frontier Research Center (WPI IFReC), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
– name: 8 Department of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA
– name: 5 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
– name: 18 Department of Pathology, Columbia University Medical Center, New York, New York, USA
– name: 19 Department of Pediatrics, Columbia University Medical Center, New York, New York, USA
– name: 12 Shaare Zedek Medical Center, Jerusalem, Israel
– name: 15 Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1Yamada-oka, Suita, Osaka 565-0871, Japan
Author_xml – sequence: 1
  givenname: Panagiotis
  surname: Ntziachristos
  fullname: Ntziachristos, Panagiotis
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
– sequence: 2
  givenname: Aristotelis
  surname: Tsirigos
  fullname: Tsirigos, Aristotelis
  email: Aristotelis.Tsirigos@nyumc.org
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, Center for Health Informatics and Bioinformatics, NYU School of Medicine
– sequence: 3
  givenname: G. Grant
  surname: Welstead
  fullname: Welstead, G. Grant
  organization: Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Present address: Editas Medicine, Cambridge, Massachusetts 02142, USA
– sequence: 4
  givenname: Thomas
  surname: Trimarchi
  fullname: Trimarchi, Thomas
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
– sequence: 5
  givenname: Sofia
  surname: Bakogianni
  fullname: Bakogianni, Sofia
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
– sequence: 6
  givenname: Luyao
  surname: Xu
  fullname: Xu, Luyao
  organization: Institute for Cancer Genetics, Columbia University Medical Center
– sequence: 7
  givenname: Evangelia
  surname: Loizou
  fullname: Loizou, Evangelia
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
– sequence: 8
  givenname: Linda
  surname: Holmfeldt
  fullname: Holmfeldt, Linda
  organization: Department of Pathology, St. Jude Children’s Research Hospital
– sequence: 9
  givenname: Alexandros
  surname: Strikoudis
  fullname: Strikoudis, Alexandros
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
– sequence: 10
  givenname: Bryan
  surname: King
  fullname: King, Bryan
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
– sequence: 11
  givenname: Jasper
  surname: Mullenders
  fullname: Mullenders, Jasper
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
– sequence: 12
  givenname: Jared
  surname: Becksfort
  fullname: Becksfort, Jared
  organization: Department of Computational Biology, St. Jude Children’s Research Hospital
– sequence: 13
  givenname: Jelena
  surname: Nedjic
  fullname: Nedjic, Jelena
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
– sequence: 14
  givenname: Elisabeth
  surname: Paietta
  fullname: Paietta, Elisabeth
  organization: Montefiore Medical Center North, Bronx
– sequence: 15
  givenname: Martin S.
  surname: Tallman
  fullname: Tallman, Martin S.
  organization: Memorial Sloan Kettering Cancer Center
– sequence: 16
  givenname: Jacob M.
  surname: Rowe
  fullname: Rowe, Jacob M.
  organization: Technion, Israel Institute of Technology, Shaare Zedek Medical Center
– sequence: 17
  givenname: Giovanni
  surname: Tonon
  fullname: Tonon, Giovanni
  organization: Division of Molecular Oncology, Functional Genomics of Cancer Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy
– sequence: 18
  givenname: Takashi
  surname: Satoh
  fullname: Satoh, Takashi
  organization: Laboratory of Host Defense, WPI Immunology Frontier Research Center (WPI IFReC), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan, Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1Yamada-oka, Suita, Osaka 565-0871, Japan
– sequence: 19
  givenname: Laurens
  surname: Kruidenier
  fullname: Kruidenier, Laurens
  organization: Epinova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline R&D, Medicines Research Centre, GunnelsWood Road, Stevenage SG1 2NY, UK
– sequence: 20
  givenname: Rab
  surname: Prinjha
  fullname: Prinjha, Rab
  organization: Epinova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline R&D, Medicines Research Centre, GunnelsWood Road, Stevenage SG1 2NY, UK
– sequence: 21
  givenname: Shizuo
  surname: Akira
  fullname: Akira, Shizuo
  organization: Laboratory of Host Defense, WPI Immunology Frontier Research Center (WPI IFReC), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan, Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1Yamada-oka, Suita, Osaka 565-0871, Japan
– sequence: 22
  givenname: Pieter
  surname: Van Vlierberghe
  fullname: Van Vlierberghe, Pieter
  organization: Institute for Cancer Genetics, Columbia University Medical Center, Center for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium
– sequence: 23
  givenname: Adolfo A.
  surname: Ferrando
  fullname: Ferrando, Adolfo A.
  organization: Institute for Cancer Genetics, Columbia University Medical Center, Department of Pathology, Columbia University Medical Center, Department of Pediatrics, Columbia University Medical Center
– sequence: 24
  givenname: Rudolf
  surname: Jaenisch
  fullname: Jaenisch, Rudolf
  organization: Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology
– sequence: 25
  givenname: Charles G.
  surname: Mullighan
  fullname: Mullighan, Charles G.
  email: charles.mullighan@stjude.org
  organization: Department of Pathology, St. Jude Children’s Research Hospital
– sequence: 26
  givenname: Iannis
  surname: Aifantis
  fullname: Aifantis, Iannis
  email: Iannis.Aifantis@nyumc.org
  organization: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25132549$$D View this record in MEDLINE/PubMed
BookMark eNpt0ktv1DAUBlALFdFpYcUeRbABQYofieNskKoRj0qVkHhtLce5ybg49jR2UOff18O0MFNFWSSyjz_H1_cEHTnvAKHnBJ8RzMR7p-I0AmEcl4_QghQVzwsuqiO0wJiKHAvGj9FJCFcY45JUxRN0TEvCaFnUC_Rr6V0cVYjG9dnoLYTMd9nKhJg2yVhmN8GkD1plLQwQVxurQjLGZUpPEdL8sF75xm4TdGZh-q1gMOopetwpG-DZ3fsU_fz08cfyS3759fPF8vwy15zQmDdE05YLTVlbNrxtucKtprpTutaqFnUrNCtKpatSV7ostaJMtIxXNfCG8q5mp-jDLnc9NQO0GraHsXI9mkGNG-mVkYczzqxk7__IguKaYpYCXt8FjP56ghDlYIIGa5UDPwVJOOGFwISIRF89oFd-Gl06XlKUMi7qqvivemVBGtf5tK_ehspzJgTlBa6rpPIZ1YOD9JOp8p1Jwwf-5YzXa3Mt99HZDEpPujqjZ1PfHCxIJsJN7NUUgrz4_u3Qvtiv9L8S37dSAmQH9OhDGKGT2kQVzd_-MlYSLLftKvfaNa15-2DNfey8frfTISnXw7h3ATP8Fg3r-WE
CODEN NATUAS
CitedBy_id crossref_primary_10_1007_s12185_022_03466_x
crossref_primary_10_1038_s44319_025_00502_9
crossref_primary_10_1002_ijc_32116
crossref_primary_10_1101_gad_284109_116
crossref_primary_10_1038_s41389_018_0112_0
crossref_primary_10_1038_s41572_024_00525_x
crossref_primary_10_1038_s41698_017_0005_2
crossref_primary_10_3390_cancers9010002
crossref_primary_10_1016_j_semcancer_2017_09_001
crossref_primary_10_1038_s41467_021_24618_3
crossref_primary_10_1016_j_bbcan_2016_03_002
crossref_primary_10_1186_s12885_021_08282_w
crossref_primary_10_3389_fonc_2019_00198
crossref_primary_10_1182_blood_2017_02_739490
crossref_primary_10_1101_gad_255182_114
crossref_primary_10_3389_fimmu_2018_02272
crossref_primary_10_1182_blood_2024026848
crossref_primary_10_1038_s41598_020_79122_3
crossref_primary_10_1182_blood_2019001044
crossref_primary_10_3389_fonc_2017_00218
crossref_primary_10_1016_j_gde_2016_01_003
crossref_primary_10_1016_j_it_2015_12_004
crossref_primary_10_1186_s12920_018_0469_0
crossref_primary_10_1002_path_4647
crossref_primary_10_1038_s41375_023_01928_7
crossref_primary_10_1002_cmdc_201800198
crossref_primary_10_1124_molpharm_121_000372
crossref_primary_10_1136_gutjnl_2021_325405
crossref_primary_10_1016_j_biocel_2015_07_006
crossref_primary_10_1210_jc_2018_00423
crossref_primary_10_3389_fnmol_2017_00051
crossref_primary_10_1016_j_exphem_2017_10_002
crossref_primary_10_1007_s00432_018_2631_7
crossref_primary_10_1038_s41418_020_00694_8
crossref_primary_10_1146_annurev_cancerbio_050216_034333
crossref_primary_10_1038_srep26711
crossref_primary_10_1172_JCI163964
crossref_primary_10_1016_j_pharmthera_2015_07_004
crossref_primary_10_3390_cells11071113
crossref_primary_10_1007_s00345_018_2594_y
crossref_primary_10_1002_advs_202004319
crossref_primary_10_1080_15592294_2016_1278095
crossref_primary_10_1074_jbc_M115_662650
crossref_primary_10_1186_s13071_020_04094_2
crossref_primary_10_4049_jimmunol_1700475
crossref_primary_10_1016_j_ccell_2019_01_001
crossref_primary_10_3390_cells10123349
crossref_primary_10_1007_s13238_019_0653_9
crossref_primary_10_1038_ng_3726
crossref_primary_10_1038_s41598_021_83857_y
crossref_primary_10_1042_BCJ20180968
crossref_primary_10_1172_JCI173403
crossref_primary_10_1128_MCB_00341_20
crossref_primary_10_1038_s41375_019_0497_6
crossref_primary_10_1016_j_biopha_2019_109384
crossref_primary_10_1016_j_stem_2016_11_003
crossref_primary_10_1016_j_molcel_2015_10_042
crossref_primary_10_1080_14728222_2018_1451840
crossref_primary_10_1038_s41467_021_27502_2
crossref_primary_10_1182_blood_2015_07_655928
crossref_primary_10_1016_j_bmcl_2023_129466
crossref_primary_10_4049_jimmunol_2001459
crossref_primary_10_1038_s41568_020_00303_3
crossref_primary_10_1128_MCB_00089_16
crossref_primary_10_1007_s00381_016_3161_8
crossref_primary_10_1101_gr_266924_120
crossref_primary_10_4103_ijc_IJC_567_19
crossref_primary_10_1016_j_molcel_2025_06_025
crossref_primary_10_1186_s10020_024_01023_2
crossref_primary_10_1016_j_yexcr_2017_08_024
crossref_primary_10_1038_onc_2017_157
crossref_primary_10_3892_mmr_2025_13671
crossref_primary_10_1007_s00120_014_3756_1
crossref_primary_10_1038_ni_3644
crossref_primary_10_1038_s41467_018_05548_z
crossref_primary_10_1371_journal_pone_0152142
crossref_primary_10_1038_ng_3909
crossref_primary_10_1038_s41375_019_0462_4
crossref_primary_10_2217_epi_15_84
crossref_primary_10_1016_j_canlet_2020_11_031
crossref_primary_10_1038_s41375_023_02052_2
crossref_primary_10_1093_gpbjnl_qzaf029
crossref_primary_10_1016_j_exphem_2015_05_017
crossref_primary_10_1038_nrc_2016_63
crossref_primary_10_15252_embr_201540244
crossref_primary_10_1038_ncomms7094
crossref_primary_10_1038_ncomms9152
crossref_primary_10_1016_j_neuint_2019_01_006
crossref_primary_10_1016_j_exphem_2016_03_001
crossref_primary_10_1038_leu_2016_165
crossref_primary_10_3390_ijms22020968
crossref_primary_10_3389_fcell_2022_909557
crossref_primary_10_3390_jcm8030288
crossref_primary_10_1371_journal_pone_0255706
crossref_primary_10_1101_gad_351408_123
crossref_primary_10_1186_s13062_016_0158_x
crossref_primary_10_1038_ni_3517
crossref_primary_10_1016_j_exphem_2015_05_001
crossref_primary_10_1158_1078_0432_CCR_18_3890
crossref_primary_10_1016_j_pharmthera_2015_01_002
crossref_primary_10_3390_cancers12113166
crossref_primary_10_1002_jcb_27744
crossref_primary_10_1158_0008_5472_CAN_16_1306
crossref_primary_10_1038_nrc_2016_148
crossref_primary_10_1038_nchembio_2007
crossref_primary_10_1016_j_stem_2018_08_018
crossref_primary_10_1182_blood_2015_02_580043
crossref_primary_10_1158_1078_0432_CCR_20_1741
crossref_primary_10_1016_j_isci_2023_108079
crossref_primary_10_3389_fimmu_2022_881396
crossref_primary_10_1002_gcc_22806
crossref_primary_10_1182_bloodadvances_2018024166
crossref_primary_10_1016_j_csbj_2018_06_001
crossref_primary_10_1016_j_cancergen_2015_01_005
crossref_primary_10_1038_s41467_024_46119_9
crossref_primary_10_3390_epigenomes3010001
crossref_primary_10_1038_s41568_021_00357_x
crossref_primary_10_1038_nrg_2016_93
crossref_primary_10_3389_fonc_2018_00448
crossref_primary_10_1007_s00018_017_2596_8
crossref_primary_10_1038_s41392_019_0040_2
crossref_primary_10_1113_JP277367
crossref_primary_10_1073_pnas_1716589115
crossref_primary_10_3390_cancers16244149
crossref_primary_10_2217_epi_2017_0092
crossref_primary_10_1038_s41598_018_37340_w
crossref_primary_10_1158_2159_8290_CD_19_1436
crossref_primary_10_1038_s41418_021_00921_w
crossref_primary_10_1080_15592294_2017_1413517
crossref_primary_10_1080_15592294_2023_2222245
crossref_primary_10_1101_gad_276790_115
crossref_primary_10_1186_s13045_014_0094_0
crossref_primary_10_1038_nrc_2016_30
crossref_primary_10_1016_j_biochi_2021_02_005
crossref_primary_10_1002_ijc_34819
crossref_primary_10_1038_s41419_020_03354_4
crossref_primary_10_1182_blood_2016_10_706465
crossref_primary_10_1007_s00018_015_2023_y
crossref_primary_10_1096_fj_201801035R
crossref_primary_10_1126_science_aad9780
crossref_primary_10_1016_j_neuropharm_2018_08_030
crossref_primary_10_1158_0008_5472_CAN_16_0826
crossref_primary_10_1038_s41392_019_0043_z
crossref_primary_10_15252_embj_2019103949
crossref_primary_10_3389_fphar_2020_00632
crossref_primary_10_1172_JCI95946
crossref_primary_10_1172_JCI96915
crossref_primary_10_1016_j_gde_2016_03_010
crossref_primary_10_1182_bloodadvances_2019000938
crossref_primary_10_3390_cancers13205106
crossref_primary_10_1186_s12967_024_05990_2
crossref_primary_10_1007_s10120_018_0888_9
crossref_primary_10_1021_jacs_5c01662
crossref_primary_10_1016_j_molcel_2015_06_027
crossref_primary_10_3389_fgene_2021_680633
crossref_primary_10_1007_s12038_019_9969_0
crossref_primary_10_1038_s41375_022_01605_1
crossref_primary_10_1007_s12094_021_02773_9
crossref_primary_10_1016_j_phrs_2016_01_026
crossref_primary_10_3390_ijms18091904
crossref_primary_10_1002_jcp_31178
crossref_primary_10_1016_j_mcn_2017_09_003
crossref_primary_10_3389_fphar_2018_00792
crossref_primary_10_1016_j_ccell_2018_01_006
crossref_primary_10_1016_j_coph_2015_05_009
crossref_primary_10_1016_j_stem_2019_03_005
crossref_primary_10_1182_blood_2020010081
crossref_primary_10_1186_s13059_020_02152_7
crossref_primary_10_3390_epigenomes7020010
crossref_primary_10_1158_1078_0432_CCR_18_1740
crossref_primary_10_3390_cancers15123117
crossref_primary_10_3389_fcell_2021_642931
crossref_primary_10_2174_0929867324666170921101947
crossref_primary_10_1007_s11060_016_2349_9
crossref_primary_10_2217_ijh_14_44
crossref_primary_10_1016_j_ctarc_2017_06_003
crossref_primary_10_1080_14728222_2019_1580692
crossref_primary_10_1096_fj_15_277053
crossref_primary_10_1172_JCI86798
crossref_primary_10_7554_eLife_39380
crossref_primary_10_1038_s41467_020_18900_z
crossref_primary_10_1016_j_molcel_2024_11_040
crossref_primary_10_1016_j_semcancer_2022_12_011
crossref_primary_10_1016_j_it_2020_02_004
crossref_primary_10_1038_s41375_023_01853_9
crossref_primary_10_3389_fimmu_2017_00396
crossref_primary_10_52586_4981
crossref_primary_10_1097_HS9_0000000000000916
crossref_primary_10_1002_advs_202405537
crossref_primary_10_3390_ijms24054539
crossref_primary_10_1038_nrc3884
crossref_primary_10_1158_0008_5472_CAN_18_3511
crossref_primary_10_1038_nrclinonc_2015_38
crossref_primary_10_1111_gtc_12767
crossref_primary_10_1095_biolreprod_115_138115
crossref_primary_10_1002_ijc_33527
crossref_primary_10_1007_s00432_021_03800_6
crossref_primary_10_1016_j_cell_2016_04_012
crossref_primary_10_1016_j_gde_2016_04_002
crossref_primary_10_1038_leu_2017_141
crossref_primary_10_1186_s12935_020_01297_6
crossref_primary_10_1016_j_ejmech_2021_113865
crossref_primary_10_1016_j_cyto_2017_10_025
crossref_primary_10_1146_annurev_cancerbio_050216_034422
crossref_primary_10_1158_0008_5472_CAN_19_1471
crossref_primary_10_1038_s41588_018_0114_z
crossref_primary_10_3390_cancers12102792
crossref_primary_10_1371_journal_ppat_1010014
crossref_primary_10_1007_s00109_017_1512_x
crossref_primary_10_1016_j_biopha_2025_118254
crossref_primary_10_1080_15384101_2017_1295194
crossref_primary_10_1080_14737140_2023_2271662
crossref_primary_10_1242_dmm_049991
crossref_primary_10_4049_jimmunol_2000624
crossref_primary_10_3390_ijms22126321
crossref_primary_10_3390_genes12081118
crossref_primary_10_1038_ncb3424
crossref_primary_10_1126_scitranslmed_aal5272
crossref_primary_10_4155_fmc_15_127
crossref_primary_10_1007_s00281_019_00731_w
crossref_primary_10_3390_molecules23081958
crossref_primary_10_3389_fonc_2020_00799
crossref_primary_10_3390_cancers11040481
crossref_primary_10_1016_j_semcancer_2020_12_014
crossref_primary_10_1007_s12288_015_0609_z
crossref_primary_10_3390_ijms161126000
crossref_primary_10_1186_s13045_018_0567_7
crossref_primary_10_2217_epi_2017_0142
crossref_primary_10_1038_s41467_018_05084_w
crossref_primary_10_1038_s41419_025_07658_1
crossref_primary_10_1038_icb_2014_116
crossref_primary_10_1200_JCO_2016_71_8585
crossref_primary_10_1038_nm_3769
crossref_primary_10_1038_s41598_017_06914_5
crossref_primary_10_1136_bmjonc_2023_000199
crossref_primary_10_1002_iub_2110
crossref_primary_10_2217_epi_15_24
crossref_primary_10_1038_s41375_020_0845_6
crossref_primary_10_1158_0008_5472_CAN_15_0536
crossref_primary_10_1186_s13148_022_01305_8
crossref_primary_10_3389_fendo_2020_00062
crossref_primary_10_1038_s41375_018_0011_6
crossref_primary_10_1016_j_semcancer_2021_03_025
crossref_primary_10_1126_sciadv_1501354
crossref_primary_10_1016_j_prp_2025_156011
crossref_primary_10_1111_imr_12237
crossref_primary_10_1038_s41375_023_01833_z
crossref_primary_10_1371_journal_pone_0174775
crossref_primary_10_3389_fimmu_2019_00688
crossref_primary_10_1007_s41048_018_0062_2
crossref_primary_10_4155_fmc_15_140
crossref_primary_10_1016_j_bbamcr_2016_01_006
crossref_primary_10_1016_j_exphem_2016_05_006
crossref_primary_10_2217_epi_2019_0312
crossref_primary_10_1182_blood_2014_11_607838
crossref_primary_10_1002_jcp_29615
Cites_doi 10.1084/jem.20112239
10.1101/gad.511109
10.1016/j.ccr.2010.08.006
10.1182/blood-2012-08-452003
10.1084/jem.20042524
10.1073/pnas.1109023108
10.1038/nature09727
10.1038/nm.2651
10.1038/sj.leu.2404258
10.1182/blood-2009-08-231217
10.1038/nature06270
10.1214/11-AOAS466
10.1038/nrm3327
10.1073/pnas.1210787109
10.1016/j.cell.2007.08.019
10.1101/gad.1673508
10.1016/j.cell.2013.05.041
10.1038/ni.1920
10.1101/gad.186411.111
10.1038/nrc3130
10.1038/ng.349
10.1073/pnas.0506580102
10.1056/NEJMoa040465
10.1371/journal.pcbi.0010053
10.1038/nature10725
10.1182/blood-2008-02-138172
10.1007/978-1-61779-074-4_17
10.1128/MCB.01091-06
10.1101/pdb.prot5652
10.1182/blood-2010-10-311019
10.1101/gad.1882610
10.1101/sqb.2010.75.020
10.1101/gr.6151507
10.1038/nature11272
10.1038/ng1651
10.3324/haematol.13299
10.1016/j.cell.2013.02.006
10.1038/leu.2012.56
10.1126/science.1102160
10.1038/nature11262
10.1073/pnas.1204166109
10.1093/bioinformatics/btp612
10.1093/bioinformatics/btr646
10.1371/journal.pone.0060020
10.1101/gad.510809
10.1186/gb-2008-9-9-r137
10.1186/gb-2009-10-3-r25
ContentType Journal Article
Copyright Springer Nature Limited 2014
COPYRIGHT 2014 Nature Publishing Group
Copyright Nature Publishing Group Oct 23, 2014
Copyright_xml – notice: Springer Nature Limited 2014
– notice: COPYRIGHT 2014 Nature Publishing Group
– notice: Copyright Nature Publishing Group Oct 23, 2014
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QG
7QL
7QP
7QR
7RV
7SN
7SS
7ST
7T5
7TG
7TK
7TM
7TO
7U9
7X2
7X7
7XB
88A
88E
88G
88I
8AF
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
8G5
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BEC
BENPR
BGLVJ
BHPHI
BKSAR
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M2M
M2O
M2P
M7N
M7P
M7S
MBDVC
NAPCQ
P5Z
P62
P64
PATMY
PCBAR
PDBOC
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PSYQQ
PTHSS
PYCSY
Q9U
R05
RC3
S0X
SOI
7X8
5PM
DOI 10.1038/nature13605
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
Science Database (Alumni Edition)
STEM Database
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
Materials Science & Engineering Collection
ProQuest Central (Alumni Edition)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Computer Science Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
eLibrary
ProQuest Central
Technology Collection
Natural Science Collection
Earth, Atmospheric & Aquatic Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
ProQuest Biological Science Collection
Agricultural Science Database
Health & Medical Collection (Alumni Edition)
Medical Database
Psychology Database
Research Library
Science Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Research Library (Corporate)
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Earth, Atmospheric & Aquatic Science Database
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
Engineering Collection
Environmental Science Collection
ProQuest Central Basic
University of Michigan
Genetics Abstracts
SIRS Editorial
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
ProQuest One Psychology
Research Library Prep
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
elibrary
ProQuest AP Science
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Earth, Atmospheric & Aquatic Science Database
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
University of Michigan
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
SIRS Editorial
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Earth, Atmospheric & Aquatic Science Collection
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Research Library
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Central Basic
ProQuest Science Journals
ProQuest Nursing & Allied Health Source
ProQuest Psychology Journals (Alumni)
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
ProQuest Psychology Journals
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
Agricultural Science Database

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: PATMY
  name: Environmental Science Database
  url: http://search.proquest.com/environmentalscience
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Physics
EISSN 1476-4687
EndPage 517
ExternalDocumentID PMC4209203
3491369381
A388264097
25132549
10_1038_nature13605
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: U10 CA021115
– fundername: NCI NIH HHS
  grantid: R01 CA173636
– fundername: NCI NIH HHS
  grantid: U10 CA21115
– fundername: Howard Hughes Medical Institute
– fundername: NCI NIH HHS
  grantid: U10 CA180827
– fundername: NCI NIH HHS
  grantid: R01CA120196
– fundername: NCI NIH HHS
  grantid: 5P30CA16087-31
– fundername: NCI NIH HHS
  grantid: 1R01CA133379
– fundername: NCI NIH HHS
  grantid: T32 CA009161
– fundername: NCI NIH HHS
  grantid: R01 CA149655
GroupedDBID ---
--Z
-DZ
-ET
-~X
.55
.CO
.XZ
00M
07C
0R~
0WA
123
186
1OL
1VR
29M
2KS
2XV
39C
3V.
4.4
41X
53G
5RE
6TJ
70F
7RV
7X2
7X7
7XC
85S
88A
88E
88I
8AF
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
8G5
8R4
8R5
8WZ
97F
97L
A6W
A7Z
A8Z
AAEEF
AAHBH
AAHTB
AAIKC
AAKAB
AAKAS
AAMNW
AASDW
AAYEP
AAYZH
AAZLF
ABAWZ
ABDBF
ABDQB
ABFSI
ABIVO
ABJCF
ABJNI
ABLJU
ABOCM
ABPEJ
ABPPZ
ABUWG
ABWJO
ABZEH
ACBEA
ACBWK
ACGFO
ACGFS
ACGOD
ACIWK
ACKOT
ACMJI
ACNCT
ACPRK
ACUHS
ACWUS
ADBBV
ADFRT
ADUKH
ADYSU
ADZCM
AENEX
AEUYN
AFFNX
AFKRA
AFLOW
AFRAH
AFSHS
AGAYW
AGHSJ
AGHTU
AGNAY
AGSOS
AHMBA
AHSBF
AIDAL
AIDUJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
APEBS
ARAPS
ARMCB
ARTTT
ASPBG
ATCPS
ATWCN
AVWKF
AXYYD
AZFZN
AZQEC
B0M
BBNVY
BCU
BDKGC
BEC
BENPR
BGLVJ
BHPHI
BIN
BKEYQ
BKKNO
BKSAR
BLC
BPHCQ
BVXVI
CCPQU
CJ0
CS3
D1I
D1J
D1K
DO4
DU5
DWQXO
E.-
E.L
EAD
EAP
EAS
EAZ
EBC
EBD
EBO
EBS
ECC
EE.
EJD
EMB
EMF
EMH
EMK
EMOBN
EPL
EPS
ESE
ESN
ESX
EX3
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
GNUQQ
GUQSH
HCIFZ
HMCUK
HVGLF
HZ~
I-F
IAO
ICQ
IEA
IEP
IGS
IH2
IHR
INH
INR
IOF
IPY
ISR
ITC
K6-
KB.
KOO
L6V
L7B
LK5
LK8
LSO
M0K
M0L
M1P
M2M
M2O
M2P
M7P
M7R
M7S
N9A
NAPCQ
NEJ
NEPJS
O9-
OBC
OES
OHH
OMK
OVD
P-O
P2P
P62
PATMY
PCBAR
PDBOC
PKN
PM3
PQQKQ
PROAC
PSQYO
PSYQQ
PTHSS
PYCSY
Q2X
R05
RND
RNS
RNT
RNTTT
RXW
S0X
SC5
SHXYY
SIXXV
SJFOW
SJN
SNYQT
SOJ
SV3
TAE
TAOOD
TBHMF
TDRGL
TEORI
TH9
TN5
TSG
TUS
TWZ
U5U
UIG
UKHRP
UKR
UMD
UQL
VQA
VVN
WH7
WOW
X7M
XIH
XKW
XZL
Y6R
YAE
YCJ
YFH
YIF
YIN
YNT
YOC
YQT
YR2
YR5
YXB
YZZ
Z5M
ZCA
ZE2
ZKB
~02
~7V
~88
~8M
~KM
AARCD
AAYXX
ABFSG
ABUFD
ACSTC
ADXHL
AETEA
AFANA
AFFHD
ALPWD
ATHPR
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
ADGHP
CGR
CUY
CVF
ECM
EIF
NPM
ACMFV
AEIIB
PMFND
7QG
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7TG
7TK
7TM
7TO
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
KL.
M7N
MBDVC
P64
PKEHL
PQEST
PQUKI
PRINS
Q9U
RC3
SOI
7X8
ESTFP
PUEGO
5PM
ID FETCH-LOGICAL-c612t-b1c2d68c23d5b6dd6a0dc2cfac9ca989d8c345ac75c7c55ca238d3679e6b26f93
IEDL.DBID M7P
ISICitedReferencesCount 302
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000343775900045&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0028-0836
1476-4687
IngestDate Tue Nov 04 01:58:26 EST 2025
Thu Oct 02 20:27:43 EDT 2025
Sat Nov 29 14:33:48 EST 2025
Mon Nov 24 16:06:56 EST 2025
Mon Nov 24 15:52:38 EST 2025
Tue Jun 10 15:34:20 EDT 2025
Mon Nov 24 15:47:46 EST 2025
Wed Nov 26 10:08:47 EST 2025
Mon Jul 21 06:02:52 EDT 2025
Tue Nov 18 22:23:13 EST 2025
Sat Nov 29 05:17:33 EST 2025
Fri Feb 21 02:37:27 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7523
Language English
License Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c612t-b1c2d68c23d5b6dd6a0dc2cfac9ca989d8c345ac75c7c55ca238d3679e6b26f93
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC4209203
PMID 25132549
PQID 1622368974
PQPubID 40569
PageCount 5
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4209203
proquest_miscellaneous_1616480118
proquest_journals_1622368974
gale_infotracmisc_A388264097
gale_infotracgeneralonefile_A388264097
gale_infotraccpiq_388264097
gale_infotracacademiconefile_A388264097
gale_incontextgauss_ISR_A388264097
pubmed_primary_25132549
crossref_citationtrail_10_1038_nature13605
crossref_primary_10_1038_nature13605
springer_journals_10_1038_nature13605
PublicationCentury 2000
PublicationDate 2014-10-23
PublicationDateYYYYMMDD 2014-10-23
PublicationDate_xml – month: 10
  year: 2014
  text: 2014-10-23
  day: 23
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationSubtitle International weekly journal of science
PublicationTitle Nature (London)
PublicationTitleAbbrev Nature
PublicationTitleAlternate Nature
PublicationYear 2014
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Morales Torres, Laugesen, Helin (CR9) 2013; 8
van Haaften (CR20) 2009; 41
Wang (CR18) 2010; 24
Mullighan (CR37) 2011; 471
Li, Brown, Huang, Bickel (CR46) 2011; 5
Zhao (CR17) 2013; 152
Simon (CR6) 2012; 26
Sen, Webster, Barragan, Chang, Khavari (CR16) 2008; 22
King (CR32) 2013; 153
Van Vlierberghe (CR25) 2011; 208
Zhang (CR2) 2012; 481
Espinosa (CR23) 2010; 18
Marks (CR40) 2009; 114
Mansour (CR11) 2012; 488
Wang (CR27) 2011; 108
Kooistra, Helin (CR8) 2012; 13
Welstead (CR28) 2012; 109
Baylin, Jones (CR1) 2011; 11
Thieme (CR19) 2013; 121
Jepsen (CR15) 2007; 450
Palomero (CR30) 2006; 20
Barradas (CR14) 2009; 23
Langmead, Trapnell, Pop, Salzberg (CR43) 2009; 10
Agger (CR13) 2009; 23
Weng (CR22) 2004; 306
Sharma (CR31) 2006; 26
Wang, Feng, Wang, Wang, Zhang (CR44) 2010; 26
Dik (CR24) 2005; 201
Kruidenier (CR5) 2012; 488
Hubner, Spector (CR7) 2010; 75
Mar (CR21) 2012; 26
Zhong (CR35) 2011; 2011
Subramanian (CR42) 2005; 102
Zhang (CR45) 2008; 9
Mullighan (CR36) 2011; 730
Chen (CR39) 2007; 17
Wang (CR10) 2012; 109
Dickins (CR34) 2005; 37
Armstrong (CR33) 2009; 113
Satoh (CR29) 2010; 11
Jankowska (CR3) 2011; 118
Ntziachristos (CR4) 2012; 18
Valk (CR26) 2004; 350
Tsirigos, Haiminen, Bilal, Utro (CR47) 2012; 28
Verhaak (CR41) 2009; 94
Zhang (CR38) 2005; 1
De Santa (CR12) 2007; 130
PJ Valk (BFnature13605_CR26) 2004; 350
T Satoh (BFnature13605_CR29) 2010; 11
MR Hubner (BFnature13605_CR7) 2010; 75
S Thieme (BFnature13605_CR19) 2013; 121
RG Verhaak (BFnature13605_CR41) 2009; 94
B Langmead (BFnature13605_CR43) 2009; 10
G van Haaften (BFnature13605_CR20) 2009; 41
F De Santa (BFnature13605_CR12) 2007; 130
BG Mar (BFnature13605_CR21) 2012; 26
F Armstrong (BFnature13605_CR33) 2009; 113
CG Mullighan (BFnature13605_CR37) 2011; 471
WA Dik (BFnature13605_CR24) 2005; 201
P Ntziachristos (BFnature13605_CR4) 2012; 18
K Agger (BFnature13605_CR13) 2009; 23
SB Baylin (BFnature13605_CR1) 2011; 11
AP Weng (BFnature13605_CR22) 2004; 306
L Wang (BFnature13605_CR44) 2010; 26
M Barradas (BFnature13605_CR14) 2009; 23
W Zhao (BFnature13605_CR17) 2013; 152
C Morales Torres (BFnature13605_CR9) 2013; 8
J Zhang (BFnature13605_CR38) 2005; 1
C Wang (BFnature13605_CR10) 2012; 109
A Subramanian (BFnature13605_CR42) 2005; 102
JK Wang (BFnature13605_CR18) 2010; 24
H Wang (BFnature13605_CR27) 2011; 108
L Kruidenier (BFnature13605_CR5) 2012; 488
VM Sharma (BFnature13605_CR31) 2006; 26
DI Marks (BFnature13605_CR40) 2009; 114
AM Jankowska (BFnature13605_CR3) 2011; 118
B King (BFnature13605_CR32) 2013; 153
P Van Vlierberghe (BFnature13605_CR25) 2011; 208
GG Welstead (BFnature13605_CR28) 2012; 109
J Zhang (BFnature13605_CR2) 2012; 481
K Chen (BFnature13605_CR39) 2007; 17
CG Mullighan (BFnature13605_CR36) 2011; 730
L Espinosa (BFnature13605_CR23) 2010; 18
AA Mansour (BFnature13605_CR11) 2012; 488
RA Dickins (BFnature13605_CR34) 2005; 37
Q Li (BFnature13605_CR46) 2011; 5
T Palomero (BFnature13605_CR30) 2006; 20
K Jepsen (BFnature13605_CR15) 2007; 450
C Simon (BFnature13605_CR6) 2012; 26
Y Zhang (BFnature13605_CR45) 2008; 9
GL Sen (BFnature13605_CR16) 2008; 22
SM Kooistra (BFnature13605_CR8) 2012; 13
A Tsirigos (BFnature13605_CR47) 2012; 28
S Zhong (BFnature13605_CR35) 2011; 2011
References_xml – volume: 208
  start-page: 2571
  year: 2011
  end-page: 2579
  ident: CR25
  article-title: mutations in early immature human T cell leukemias
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20112239
– volume: 23
  start-page: 1177
  year: 2009
  end-page: 1182
  ident: CR14
  article-title: Histone demethylase JMJD3 contributes to epigenetic control of by oncogenic RAS
  publication-title: Genes Dev.
  doi: 10.1101/gad.511109
– volume: 18
  start-page: 268
  year: 2010
  end-page: 281
  ident: CR23
  article-title: The Notch/Hes1 pathway sustains NF-κB activation through repression in T cell leukemia
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2010.08.006
– volume: 121
  start-page: 2462
  year: 2013
  end-page: 2473
  ident: CR19
  article-title: The histone demethylase UTX regulates stem cell migration and hematopoiesis
  publication-title: Blood
  doi: 10.1182/blood-2012-08-452003
– volume: 201
  start-page: 1715
  year: 2005
  end-page: 1723
  ident: CR24
  article-title: New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20042524
– volume: 108
  start-page: 14908
  year: 2011
  end-page: 14913
  ident: CR27
  article-title: Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1109023108
– volume: 471
  start-page: 235
  year: 2011
  end-page: 239
  ident: CR37
  article-title: mutations in relapsed acute lymphoblastic leukaemia
  publication-title: Nature
  doi: 10.1038/nature09727
– volume: 18
  start-page: 298
  year: 2012
  end-page: 303
  ident: CR4
  article-title: Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
  publication-title: Nature Med.
  doi: 10.1038/nm.2651
– volume: 20
  start-page: 1279
  year: 2006
  end-page: 1287
  ident: CR30
  article-title: CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to γ-secretase inhibitors
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2404258
– volume: 114
  start-page: 5136
  year: 2009
  end-page: 5145
  ident: CR40
  article-title: T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)
  publication-title: Blood
  doi: 10.1182/blood-2009-08-231217
– volume: 450
  start-page: 415
  year: 2007
  end-page: 419
  ident: CR15
  article-title: SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
  publication-title: Nature
  doi: 10.1038/nature06270
– volume: 5
  start-page: 1752
  year: 2011
  end-page: 1779
  ident: CR46
  article-title: Measuring reproducibility of high-throughput experiments
  publication-title: Ann. Appl. Stat.
  doi: 10.1214/11-AOAS466
– volume: 13
  start-page: 297
  year: 2012
  end-page: 311
  ident: CR8
  article-title: Molecular mechanisms and potential functions of histone demethylases
  publication-title: Nature Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3327
– volume: 109
  start-page: 13004
  year: 2012
  end-page: 13009
  ident: CR28
  article-title: X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1210787109
– volume: 130
  start-page: 1083
  year: 2007
  end-page: 1094
  ident: CR12
  article-title: The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
  publication-title: Cell
  doi: 10.1016/j.cell.2007.08.019
– volume: 22
  start-page: 1865
  year: 2008
  end-page: 1870
  ident: CR16
  article-title: Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
  publication-title: Genes Dev.
  doi: 10.1101/gad.1673508
– volume: 153
  start-page: 1552
  year: 2013
  end-page: 1566
  ident: CR32
  article-title: The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.041
– volume: 11
  start-page: 936
  year: 2010
  end-page: 944
  ident: CR29
  article-title: The Jmjd3–Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
  publication-title: Nature Immunol.
  doi: 10.1038/ni.1920
– volume: 26
  start-page: 651
  year: 2012
  end-page: 656
  ident: CR6
  article-title: A key role for and associated genes in mouse and human adult T-cell acute leukemia
  publication-title: Genes Dev.
  doi: 10.1101/gad.186411.111
– volume: 11
  start-page: 726
  year: 2011
  end-page: 734
  ident: CR1
  article-title: A decade of exploring the cancer epigenome: biological and translational implications
  publication-title: Nature Rev. Cancer
  doi: 10.1038/nrc3130
– volume: 41
  start-page: 521
  year: 2009
  end-page: 523
  ident: CR20
  article-title: Somatic mutations of the histone H3K27 demethylase gene in human cancer
  publication-title: Nature Genet.
  doi: 10.1038/ng.349
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: CR42
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 350
  start-page: 1617
  year: 2004
  end-page: 1628
  ident: CR26
  article-title: Prognostically useful gene-expression profiles in acute myeloid leukemia
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa040465
– volume: 1
  start-page: e53
  year: 2005
  ident: CR38
  article-title: SNPdetector: a software tool for sensitive and accurate SNP detection
  publication-title: PLOS Comput. Biol.
  doi: 10.1371/journal.pcbi.0010053
– volume: 481
  start-page: 157
  year: 2012
  end-page: 163
  ident: CR2
  article-title: The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
  publication-title: Nature
  doi: 10.1038/nature10725
– volume: 113
  start-page: 1730
  year: 2009
  end-page: 1740
  ident: CR33
  article-title: NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity
  publication-title: Blood
  doi: 10.1182/blood-2008-02-138172
– volume: 10
  start-page: R25
  year: 2009
  ident: CR43
  article-title: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
  publication-title: Genome Biol.
– volume: 730
  start-page: 235
  year: 2011
  end-page: 258
  ident: CR36
  article-title: Single nucleotide polymorphism microarray analysis of genetic alterations in cancer
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-61779-074-4_17
– volume: 26
  start-page: 8022
  year: 2006
  end-page: 8031
  ident: CR31
  article-title: Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.01091-06
– volume: 2011
  start-page: 940
  year: 2011
  end-page: 949
  ident: CR35
  article-title: High-throughput Illumina strand-specific RNA sequencing library preparation
  publication-title: Cold Spring Harb. Protoc.
  doi: 10.1101/pdb.prot5652
– volume: 118
  start-page: 3932
  year: 2011
  end-page: 3941
  ident: CR3
  article-title: Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: , , and
  publication-title: Blood
  doi: 10.1182/blood-2010-10-311019
– volume: 24
  start-page: 327
  year: 2010
  end-page: 332
  ident: CR18
  article-title: The histone demethylase UTX enables RB-dependent cell fate control
  publication-title: Genes Dev.
  doi: 10.1101/gad.1882610
– volume: 75
  start-page: 43
  year: 2010
  end-page: 49
  ident: CR7
  article-title: Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation
  publication-title: Cold Spring Harb. Symp. Quant. Biol.
  doi: 10.1101/sqb.2010.75.020
– volume: 17
  start-page: 659
  year: 2007
  end-page: 666
  ident: CR39
  article-title: PolyScan: an automatic indel and SNP detection approach to the analysis of human resequencing data
  publication-title: Genome Res.
  doi: 10.1101/gr.6151507
– volume: 488
  start-page: 409
  year: 2012
  end-page: 413
  ident: CR11
  article-title: The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
  publication-title: Nature
  doi: 10.1038/nature11272
– volume: 37
  start-page: 1289
  year: 2005
  end-page: 1295
  ident: CR34
  article-title: Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
  publication-title: Nature Genet.
  doi: 10.1038/ng1651
– volume: 94
  start-page: 131
  year: 2009
  end-page: 134
  ident: CR41
  article-title: Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling
  publication-title: Haematologica
  doi: 10.3324/haematol.13299
– volume: 152
  start-page: 1037
  year: 2013
  end-page: 1050
  ident: CR17
  article-title: Jmjd3 inhibits reprogramming by upregulating expression of and targeting PHF20 for ubiquitination
  publication-title: Cell
  doi: 10.1016/j.cell.2013.02.006
– volume: 26
  start-page: 1881
  year: 2012
  end-page: 1883
  ident: CR21
  article-title: Sequencing histone-modifying enzymes identifies mutations in acute lymphoblastic leukemia
  publication-title: Leukemia
  doi: 10.1038/leu.2012.56
– volume: 306
  start-page: 269
  year: 2004
  end-page: 271
  ident: CR22
  article-title: Activating mutations of in human T cell acute lymphoblastic leukemia
  publication-title: Science
  doi: 10.1126/science.1102160
– volume: 488
  start-page: 404
  year: 2012
  end-page: 408
  ident: CR5
  article-title: A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
  publication-title: Nature
  doi: 10.1038/nature11262
– volume: 109
  start-page: 15324
  year: 2012
  end-page: 15329
  ident: CR10
  article-title: UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1204166109
– volume: 26
  start-page: 136
  year: 2010
  end-page: 138
  ident: CR44
  article-title: DEGseq: an R package for identifying differentially expressed genes from RNA-seq data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp612
– volume: 28
  start-page: 282
  year: 2012
  end-page: 283
  ident: CR47
  article-title: GenomicTools: a computational platform for developing high-throughput analytics in genomics
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr646
– volume: 8
  start-page: e60020
  year: 2013
  ident: CR9
  article-title: Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0060020
– volume: 23
  start-page: 1171
  year: 2009
  end-page: 1176
  ident: CR13
  article-title: The H3K27me3 demethylase JMJD3 contributes to the activation of the locus in response to oncogene- and stress-induced senescence
  publication-title: Genes Dev.
  doi: 10.1101/gad.510809
– volume: 9
  start-page: R137
  year: 2008
  ident: CR45
  article-title: Model-based analysis of ChIP-Seq (MACS)
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-9-r137
– volume: 41
  start-page: 521
  year: 2009
  ident: BFnature13605_CR20
  publication-title: Nature Genet.
  doi: 10.1038/ng.349
– volume: 481
  start-page: 157
  year: 2012
  ident: BFnature13605_CR2
  publication-title: Nature
  doi: 10.1038/nature10725
– volume: 26
  start-page: 651
  year: 2012
  ident: BFnature13605_CR6
  publication-title: Genes Dev.
  doi: 10.1101/gad.186411.111
– volume: 153
  start-page: 1552
  year: 2013
  ident: BFnature13605_CR32
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.041
– volume: 94
  start-page: 131
  year: 2009
  ident: BFnature13605_CR41
  publication-title: Haematologica
  doi: 10.3324/haematol.13299
– volume: 13
  start-page: 297
  year: 2012
  ident: BFnature13605_CR8
  publication-title: Nature Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3327
– volume: 471
  start-page: 235
  year: 2011
  ident: BFnature13605_CR37
  publication-title: Nature
  doi: 10.1038/nature09727
– volume: 10
  start-page: R25
  year: 2009
  ident: BFnature13605_CR43
  publication-title: Genome Biol.
  doi: 10.1186/gb-2009-10-3-r25
– volume: 18
  start-page: 298
  year: 2012
  ident: BFnature13605_CR4
  publication-title: Nature Med.
  doi: 10.1038/nm.2651
– volume: 5
  start-page: 1752
  year: 2011
  ident: BFnature13605_CR46
  publication-title: Ann. Appl. Stat.
  doi: 10.1214/11-AOAS466
– volume: 306
  start-page: 269
  year: 2004
  ident: BFnature13605_CR22
  publication-title: Science
  doi: 10.1126/science.1102160
– volume: 109
  start-page: 15324
  year: 2012
  ident: BFnature13605_CR10
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1204166109
– volume: 109
  start-page: 13004
  year: 2012
  ident: BFnature13605_CR28
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1210787109
– volume: 108
  start-page: 14908
  year: 2011
  ident: BFnature13605_CR27
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1109023108
– volume: 28
  start-page: 282
  year: 2012
  ident: BFnature13605_CR47
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr646
– volume: 201
  start-page: 1715
  year: 2005
  ident: BFnature13605_CR24
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20042524
– volume: 208
  start-page: 2571
  year: 2011
  ident: BFnature13605_CR25
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20112239
– volume: 113
  start-page: 1730
  year: 2009
  ident: BFnature13605_CR33
  publication-title: Blood
  doi: 10.1182/blood-2008-02-138172
– volume: 450
  start-page: 415
  year: 2007
  ident: BFnature13605_CR15
  publication-title: Nature
  doi: 10.1038/nature06270
– volume: 11
  start-page: 726
  year: 2011
  ident: BFnature13605_CR1
  publication-title: Nature Rev. Cancer
  doi: 10.1038/nrc3130
– volume: 730
  start-page: 235
  year: 2011
  ident: BFnature13605_CR36
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-61779-074-4_17
– volume: 26
  start-page: 1881
  year: 2012
  ident: BFnature13605_CR21
  publication-title: Leukemia
  doi: 10.1038/leu.2012.56
– volume: 18
  start-page: 268
  year: 2010
  ident: BFnature13605_CR23
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2010.08.006
– volume: 22
  start-page: 1865
  year: 2008
  ident: BFnature13605_CR16
  publication-title: Genes Dev.
  doi: 10.1101/gad.1673508
– volume: 8
  start-page: e60020
  year: 2013
  ident: BFnature13605_CR9
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0060020
– volume: 17
  start-page: 659
  year: 2007
  ident: BFnature13605_CR39
  publication-title: Genome Res.
  doi: 10.1101/gr.6151507
– volume: 75
  start-page: 43
  year: 2010
  ident: BFnature13605_CR7
  publication-title: Cold Spring Harb. Symp. Quant. Biol.
  doi: 10.1101/sqb.2010.75.020
– volume: 488
  start-page: 409
  year: 2012
  ident: BFnature13605_CR11
  publication-title: Nature
  doi: 10.1038/nature11272
– volume: 23
  start-page: 1171
  year: 2009
  ident: BFnature13605_CR13
  publication-title: Genes Dev.
  doi: 10.1101/gad.510809
– volume: 24
  start-page: 327
  year: 2010
  ident: BFnature13605_CR18
  publication-title: Genes Dev.
  doi: 10.1101/gad.1882610
– volume: 9
  start-page: R137
  year: 2008
  ident: BFnature13605_CR45
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-9-r137
– volume: 152
  start-page: 1037
  year: 2013
  ident: BFnature13605_CR17
  publication-title: Cell
  doi: 10.1016/j.cell.2013.02.006
– volume: 121
  start-page: 2462
  year: 2013
  ident: BFnature13605_CR19
  publication-title: Blood
  doi: 10.1182/blood-2012-08-452003
– volume: 37
  start-page: 1289
  year: 2005
  ident: BFnature13605_CR34
  publication-title: Nature Genet.
  doi: 10.1038/ng1651
– volume: 11
  start-page: 936
  year: 2010
  ident: BFnature13605_CR29
  publication-title: Nature Immunol.
  doi: 10.1038/ni.1920
– volume: 20
  start-page: 1279
  year: 2006
  ident: BFnature13605_CR30
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2404258
– volume: 26
  start-page: 136
  year: 2010
  ident: BFnature13605_CR44
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp612
– volume: 1
  start-page: e53
  year: 2005
  ident: BFnature13605_CR38
  publication-title: PLOS Comput. Biol.
  doi: 10.1371/journal.pcbi.0010053
– volume: 114
  start-page: 5136
  year: 2009
  ident: BFnature13605_CR40
  publication-title: Blood
  doi: 10.1182/blood-2009-08-231217
– volume: 488
  start-page: 404
  year: 2012
  ident: BFnature13605_CR5
  publication-title: Nature
  doi: 10.1038/nature11262
– volume: 118
  start-page: 3932
  year: 2011
  ident: BFnature13605_CR3
  publication-title: Blood
  doi: 10.1182/blood-2010-10-311019
– volume: 102
  start-page: 15545
  year: 2005
  ident: BFnature13605_CR42
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 2011
  start-page: 940
  year: 2011
  ident: BFnature13605_CR35
  publication-title: Cold Spring Harb. Protoc.
  doi: 10.1101/pdb.prot5652
– volume: 23
  start-page: 1177
  year: 2009
  ident: BFnature13605_CR14
  publication-title: Genes Dev.
  doi: 10.1101/gad.511109
– volume: 26
  start-page: 8022
  year: 2006
  ident: BFnature13605_CR31
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.01091-06
– volume: 130
  start-page: 1083
  year: 2007
  ident: BFnature13605_CR12
  publication-title: Cell
  doi: 10.1016/j.cell.2007.08.019
– volume: 350
  start-page: 1617
  year: 2004
  ident: BFnature13605_CR26
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa040465
SSID ssj0005174
Score 2.5987866
Snippet T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3...
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly...
T cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy with dismal overall prognosis, exhibiting up to a 25% relapse rate, mainly due to the...
SourceID pubmedcentral
proquest
gale
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 513
SubjectTerms 13/31
38
38/23
38/39
45
45/15
45/91
59/5
631/337/100/2285
631/67/1990/283
Animals
Benzazepines - pharmacology
Binding sites
Epigenesis, Genetic - drug effects
Genes
Genetic aspects
Genomes
Health aspects
Histone Demethylases - genetics
Histone Demethylases - metabolism
Histones
Histones - chemistry
Histones - metabolism
Humanities and Social Sciences
Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors
Jumonji Domain-Containing Histone Demethylases - metabolism
letter
Leukemia
Lymphocytic leukemia
Lysine
Lysine - metabolism
Methylation - drug effects
Methyltransferases
Mice
multidisciplinary
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Proteins
Pyrimidines - pharmacology
Science
Studies
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Title Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
URI https://link.springer.com/article/10.1038/nature13605
https://www.ncbi.nlm.nih.gov/pubmed/25132549
https://www.proquest.com/docview/1622368974
https://www.proquest.com/docview/1616480118
https://pubmed.ncbi.nlm.nih.gov/PMC4209203
Volume 514
WOSCitedRecordID wos000343775900045&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAQT
  databaseName: Nature
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: RNT
  dateStart: 19970101
  isFulltext: true
  titleUrlDefault: https://www.nature.com
  providerName: Nature Publishing
– providerCode: PRVPQU
  databaseName: Advanced Technologies & Aerospace Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: P5Z
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/hightechjournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Agricultural Science Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: M0K
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/agriculturejournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: M7P
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Earth, Atmospheric & Aquatic Science Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: PCBAR
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/eaasdb
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Engineering Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: M7S
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: http://search.proquest.com
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Environmental Science Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: PATMY
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/environmentalscience
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: 7X7
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Materials Science Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: KB.
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/materialsscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Nursing & Allied Health Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: 7RV
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/nahs
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: BENPR
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Psychology Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: M2M
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/psychology
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Public Health Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: 8C1
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/publichealth
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Research Library
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: M2O
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/pqrl
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Science Database
  customDbUrl:
  eissn: 1476-4687
  dateEnd: 20241209
  omitProxy: false
  ssIdentifier: ssj0005174
  issn: 0028-0836
  databaseCode: M2P
  dateStart: 19880107
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/sciencejournals
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYBhIvwMZX2KgC4lsKS-PEcZ7QNm0CTStVB1PFS2Sfk1FR0q5pkfjvuXPdrSkTL7ycEt0lceLz3cU-_46xF5DRYmZaBGEKMohLnQQqjtqBppLTGkMUbbQtNpF2OrLfz7puwq12aZULm2gNtRkBzZHvtgU6MiEx_P0wvgioahStrroSGmtsg1ASuE3d616leKygMLv9eSGXu3PYzDYXVLduySOt2uUlx7SaNLmycmod0tHd_32Ve-yOC0X9vbnubLIbRbXFbtmUUKi32KYb9rX_xmFTv73PzgjNaqJqSpb2KTOx9kelb0GLq8LnPgGc4EGU-qag4tS_MThHmUHlK5hNC-Sj9oz0kO4A_rCY_VDFz4F6wL4eHX45-Bi40gwBYEg0DXQbIiMkRNwkWhgjVGggglJBBiqTmZHA40RBmkAKSQIKIwPDRZoVQkeizPhDtl5hwx4zX5sIHXXKQSYmLkOuBRpREZpSC1BJDB57t-ieHBxuOZXPGOZ2_ZzLfKkvPdS-hfB4Dtdxvdhz6uecADAqyrA5V7O6zj-d9vI9jv8cglDAPPbaCZUjfCAot2EBm02YWQ3J7YYkjAcX-RL3VYN7Pu-z626z0xDEgQ5N9kKdcmdo6vxKlzz27JJNV1LyXFWMZiSD_8SSthh77NFciS8_Doa3nOYIPJY21PtSgODHm5xq8N3CkMdRmEUh99jLxUBYatbf3_zJv5u_zW5jLBpTWBDxHbY-ncyKp-wm_JoO6kmLraW9M6L91FKJVB60W2xj_7DT7eHZ8f57pCfhMdHoxNLPlnZb1ipYeoq0m3z7AxyYZAQ
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VBQQXoOVlWmBBlJdk1dm11_YBoQqoGrVEqLRVb2Z31i4RwUnjBNQ_xW9kxo80DhW3HrhZmom9Wc9rvd9-w9hziGkzM0xdL4TI9TMTuNoXHddQy2mDJYqxpmw2EfZ60fFx_HmJ_W7OwhCssomJZaC2Q6Bv5JsdhYlMRVj-vhudutQ1inZXmxYalVnspme_cMlWvO1-wPe7IcT2x4P3O27dVcAFzOYT13RAWBWBkDYwylqlPQsCMg0x6DiKbQTSDzSEAYQQBKAxqVmpwjhVRqiMyJcw5F_BON4hCFm4f3QOKVlgfa7PA3oy2qxoOjtSUZ-8uQy4mAfmEuEiSHNhp7ZMgNu3_repu81u1qU236p8Y4Utpfkqu1ZCXqFYZSt1WCv4q5p7-_UddkRsXWNdEBicE_Ky4MOMl6TMecolJwIXvBAhtyk13z7DxQfq9HOuYTpJUY7eMTQDugPwQTr9rtMffX2XHV7KP73HlnMc2APGjRVYiIQSosD6mSeNwiShPJsZBTrwwWFvGnNIoOZlp_Ygg6TEB8gombMdB72rUR5VdCQXqz0ju0qI4CMnBNGJnhZF0v2yn2xJXFMpYjlz2MtaKRviA0HXBzJw2MQJ1tJca2nCqH-azElftKQn1Tu76DbrLUUMZNAWN-ab1IG0SM5t12FPZ2L6JYED83Q4JR1c80d0hNph9yunmU0Olu-SvoE4LGy500yB6NXbkrz_raRZ94UXC086bKNxvLlh_T3nD_89_Cfs-s7Bp71kr9vbXWM3sO72qQQScp0tT8bT9BG7Cj8n_WL8uIwpnH29bE_8A8Rjt_E
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5V5SEuQMvLtMCCKC_Jir1rr-0DQlVLRFQUVUBRb2Y9a5eI4KRxAupf49cx40ewQ8WtB26RZuJsdue13m-_YewpRHSYGaS2E0Boe1ni29oTrp1Qy-kES5TEJGWziWA4DI-Po8M19qu5C0OwyiYmloHaTIDekfdchYlMhVj-9rIaFnG4338zPbWpgxSdtDbtNCoTOUjPfuL2rXg92Me13hGi__bT3ju77jBgA2b2uZ24IIwKQUjjJ8oYpR0DAjINEegojEwI0vM1BD4E4PugMcEZqYIoVYlQGRExYfi_FEi0YrqlvteCl6wwQNd3Ax0Z9irKTlcq6pnXyoarOaGVFFcBmyuntmUy7N_4n6fxJrtel-B8t_KZDbaW5pvsSgmFhWKTbdThruAvak7ul7fYZ2LxmumCQOKcEJkFn2S8JGvOUy45EbvgBxFwk1JT7jPclKDOKOcaFvMU5eg1k2RMTwA-ThffdPp9pG-zowv5p3fYeo4Du8d4YgQWKIGE0Dde5shEYfJQjskSBdr3wGKvGtOIoeZrp7Yh47jEDcgwbtmRhV7XKE8rmpLz1Z6QjcVE_JHT2p_oRVHEg48f4l2Jey1F7GcWe14rZRP8QdD1RQ0cNnGFdTS3OpowHZ3GLemzjvSkWrPzHrPdUcQAB11xY8pxHWCL-I8dW-zxUkzfJNBgnk4WpOMqYkdyQ4vdrRxoOTlY1kt6N2KxoONaSwWiXe9K8tHXkn7dE04kHGmxncYJW8P6e87v_3v4j9hVdMD4_WB4sMWuYTnuUWUk5DZbn88W6QN2GX7MR8XsYRleOPty0Y74G6mqwEw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Contrasting+roles+of+histone+3+lysine+27+demethylases+in+acute+lymphoblastic+leukaemia&rft.jtitle=Nature+%28London%29&rft.au=Ntziachristos%2C+Panagiotis&rft.au=Tsirigos%2C+Aristotelis&rft.au=Welstead%2C+G.+Grant&rft.au=Trimarchi%2C+Thomas&rft.date=2014-10-23&rft.pub=Nature+Publishing+Group+UK&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=514&rft.issue=7523&rft.spage=513&rft.epage=517&rft_id=info:doi/10.1038%2Fnature13605&rft.externalDocID=10_1038_nature13605
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon