Regulation of the T Cell Response by CD39

The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. CD39 generates AMP, which is in turn used by the ecto-5′-nucleotidase CD73 to synthesize...

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Bibliographic Details
Published in:	Trends in immunology Vol. 37; no. 7; pp. 427 - 439
Main Authors:	Takenaka, Maisa C., Robson, Simon, Quintana, Francisco J.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.07.2016 Elsevier Limited
Subjects:	5'-Nucleotidase - metabolism Adenosine Adenosine - metabolism Adenosine Monophosphate - metabolism Allergy and Immunology Animals Antigens, CD - metabolism Apoptosis Apyrase - metabolism Autoimmune Diseases - immunology Autoimmunity Dendritic cells Enzymes Gene-Environment Interaction Humans Immune Tolerance - immunology Infection - immunology Infections Inflammation - immunology Kinases Lymphocyte Activation Lymphocytes Medical research Metabolism Metabolites Neoplasms - immunology Neutrophils Proteins T-Lymphocytes - immunology
ISSN:	1471-4906, 1471-4981, 1471-4981
Online Access:	Get full text
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