Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. A total of 11,140 men and women aged 55–88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural...

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Vydané v:	European psychiatry Ročník 28; číslo 1; s. 49 - 52
Hlavní autori:	Batty, G.-D., Li, Q., Huxley, R., Zoungas, S., Taylor, B.-A., Neal, B., de Galan, B., Woodward, M., Harrap, S.-B., Colagiuri, S., Patel, A., Chalmers, J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Paris Elsevier SAS 01.01.2013 Elsevier
Predmet:	Age Factors Aged Aged, 80 and over Biological and medical sciences Cognition Cognition Disorders - etiology Cognitive decline Cohort study Dementia Dementia - etiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Humans Internal Medicine Male Medical sciences Middle Aged Neuropsychological Tests Oral disease Periodontal Diseases - complications Prospective Studies Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Quality of Life Risk Sex Factors Socioeconomic Factors Cognitive decline Oral disease Cohort study Dementia Endocrinopathy Evaluation Cognitive disorder Diabetes mellitus Cardiovascular disease Intellectual deterioration Vascular disease Follow up study Risk factor Degenerative disease Oral cavity disease Release
ISSN:	0924-9338, 1778-3585, 1778-3585
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Popis
Shrnutí:	Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. A total of 11,140 men and women aged 55–88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Tooth loss was associated with an increased risk of both dementia and cognitive decline.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0924-9338 1778-3585 1778-3585
DOI:	10.1016/j.eurpsy.2011.07.005