T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-1) in human melanoma, most patients do not experience durable clinical benefit. Pre-existing T-cell infiltration and/or the presence of PD-L1 in tumours may be used as indicators of clinical response; however, bloo...

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Bibliographic Details
Published in:	Nature (London) Vol. 545; no. 7652; pp. 60 - 65
Main Authors:	Huang, Alexander C., Postow, Michael A., Orlowski, Robert J., Mick, Rosemarie, Bengsch, Bertram, Manne, Sasikanth, Xu, Wei, Harmon, Shannon, Giles, Josephine R., Wenz, Brandon, Adamow, Matthew, Kuk, Deborah, Panageas, Katherine S., Carrera, Cristina, Wong, Phillip, Quagliarello, Felix, Wubbenhorst, Bradley, D’Andrea, Kurt, Pauken, Kristen E., Herati, Ramin S., Staupe, Ryan P., Schenkel, Jason M., McGettigan, Suzanne, Kothari, Shawn, George, Sangeeth M., Vonderheide, Robert H., Amaravadi, Ravi K., Karakousis, Giorgos C., Schuchter, Lynn M., Xu, Xiaowei, Nathanson, Katherine L., Wolchok, Jedd D., Gangadhar, Tara C., Wherry, E. John
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.05.2017 Nature Publishing Group
Subjects:	631/250/251 631/250/580 631/67/1813/1634 631/67/1857 Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - immunology Antibodies, Monoclonal, Humanized - pharmacokinetics Antibodies, Monoclonal, Humanized - therapeutic use Apoptosis Cancer research CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell death Clinical trials Female Humanities and Social Sciences Humans Immunoglobulins Immunology Immunotherapy Infiltration Ki-67 Antigen - immunology Ki-67 Antigen - metabolism Lymphocytes Lymphocytes T Male Medical research Melanoma Melanoma - blood supply Melanoma - drug therapy Melanoma - immunology Melanoma - pathology Metastases Monoclonal antibodies multidisciplinary Neoplasm Staging Pathology Patients PD-1 protein PD-L1 protein Peripheral blood Pharmacodynamics Pharmacology Phenotype Physiological aspects Pretreatment Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Science T cell receptors T cells Treatment Outcome Tumor Burden - immunology Tumors
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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