Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Cell Therapy to Tissue Engineering

Low back pain (LBP) in one of the most disabling symptoms affecting nearly 80% of the population worldwide. Its primary cause seems to be intervertebral disc degeneration (IDD): a chronic and progressive process characterized by loss of viable cells and extracellular matrix (ECM) breakdown within th...

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Vydané v:	Stem cells international Ročník 2019; číslo 2019; s. 1 - 15
Hlavní autori:	Papalia, Rocco, Russo, Fabrizio, Ambrosio, Luca, Vadalà, Gianluca, Denaro, Vincenzo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Cairo, Egypt Hindawi Publishing Corporation 2019 Hindawi John Wiley & Sons, Inc Wiley
Predmet:	Back pain Backache Biological activity Biological treatment Biomechanics Biomedical materials Bone marrow Cartilage Cell therapy Collagen Degeneration Extracellular matrix Growth factors Homeostasis Hypoxia Immunomodulation Inflammation Intervertebral discs Kinases Low back pain Mechanical loading Mechanical properties Mesenchymal stem cells Nucleus pulposus Osmotic pressure Phenotypes Physiology Proteins Regeneration (physiology) Regenerative medicine Review Stem cells Therapy Tissue engineering Transplantation Trophic factors Viability
ISSN:	1687-966X, 1687-9678, 1687-9678
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