Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Cell Therapy to Tissue Engineering

Low back pain (LBP) in one of the most disabling symptoms affecting nearly 80% of the population worldwide. Its primary cause seems to be intervertebral disc degeneration (IDD): a chronic and progressive process characterized by loss of viable cells and extracellular matrix (ECM) breakdown within th...

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Bibliographic Details
Published in:	Stem cells international Vol. 2019; no. 2019; pp. 1 - 15
Main Authors:	Papalia, Rocco, Russo, Fabrizio, Ambrosio, Luca, Vadalà, Gianluca, Denaro, Vincenzo
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 2019 Hindawi John Wiley & Sons, Inc Wiley
Subjects:	Back pain Backache Biological activity Biological treatment Biomechanics Biomedical materials Bone marrow Cartilage Cell therapy Collagen Degeneration Extracellular matrix Growth factors Homeostasis Hypoxia Immunomodulation Inflammation Intervertebral discs Kinases Low back pain Mechanical loading Mechanical properties Mesenchymal stem cells Nucleus pulposus Osmotic pressure Phenotypes Physiology Proteins Regeneration (physiology) Regenerative medicine Review Stem cells Therapy Tissue engineering Transplantation Trophic factors Viability
ISSN:	1687-966X, 1687-9678, 1687-9678
Online Access:	Get full text
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