Master transcription factors and mediator establish super-enhancers at key cell identity genes

Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell Jg. 153; H. 2; S. 307
Hauptverfasser:	Whyte, Warren A, Orlando, David A, Hnisz, Denes, Abraham, Brian J, Lin, Charles Y, Kagey, Michael H, Rahl, Peter B, Lee, Tong Ihn, Young, Richard A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.04.2013
Schlagworte:	Animals B-Lymphocytes - metabolism Cell Line Cell Lineage Embryonic Stem Cells - metabolism Enhancer Elements, Genetic Gene Expression Regulation Gene Knockdown Techniques Humans Mediator Complex - metabolism Mice Transcription Factors - metabolism Transcription, Genetic
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!