Master transcription factors and mediator establish super-enhancers at key cell identity genes

Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control...

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Published in:	Cell Vol. 153; no. 2; p. 307
Main Authors:	Whyte, Warren A, Orlando, David A, Hnisz, Denes, Abraham, Brian J, Lin, Charles Y, Kagey, Michael H, Rahl, Peter B, Lee, Tong Ihn, Young, Richard A
Format:	Journal Article
Language:	English
Published:	United States 11.04.2013
Subjects:	Animals B-Lymphocytes - metabolism Cell Line Cell Lineage Embryonic Stem Cells - metabolism Enhancer Elements, Genetic Gene Expression Regulation Gene Knockdown Techniques Humans Mediator Complex - metabolism Mice Transcription Factors - metabolism Transcription, Genetic
ISSN:	1097-4172, 1097-4172
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Abstract	Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state. These domains, which we call super-enhancers, consist of clusters of enhancers that are densely occupied by the master regulators and Mediator. Super-enhancers differ from typical enhancers in size, transcription factor density and content, ability to activate transcription, and sensitivity to perturbation. Reduced levels of Oct4 or Mediator cause preferential loss of expression of super-enhancer-associated genes relative to other genes, suggesting how changes in gene expression programs might be accomplished during development. In other more differentiated cells, super-enhancers containing cell-type-specific master transcription factors are also found at genes that define cell identity. Super-enhancers thus play key roles in the control of mammalian cell identity.
AbstractList	Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state. These domains, which we call super-enhancers, consist of clusters of enhancers that are densely occupied by the master regulators and Mediator. Super-enhancers differ from typical enhancers in size, transcription factor density and content, ability to activate transcription, and sensitivity to perturbation. Reduced levels of Oct4 or Mediator cause preferential loss of expression of super-enhancer-associated genes relative to other genes, suggesting how changes in gene expression programs might be accomplished during development. In other more differentiated cells, super-enhancers containing cell-type-specific master transcription factors are also found at genes that define cell identity. Super-enhancers thus play key roles in the control of mammalian cell identity.Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state. These domains, which we call super-enhancers, consist of clusters of enhancers that are densely occupied by the master regulators and Mediator. Super-enhancers differ from typical enhancers in size, transcription factor density and content, ability to activate transcription, and sensitivity to perturbation. Reduced levels of Oct4 or Mediator cause preferential loss of expression of super-enhancer-associated genes relative to other genes, suggesting how changes in gene expression programs might be accomplished during development. In other more differentiated cells, super-enhancers containing cell-type-specific master transcription factors are also found at genes that define cell identity. Super-enhancers thus play key roles in the control of mammalian cell identity. Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state. These domains, which we call super-enhancers, consist of clusters of enhancers that are densely occupied by the master regulators and Mediator. Super-enhancers differ from typical enhancers in size, transcription factor density and content, ability to activate transcription, and sensitivity to perturbation. Reduced levels of Oct4 or Mediator cause preferential loss of expression of super-enhancer-associated genes relative to other genes, suggesting how changes in gene expression programs might be accomplished during development. In other more differentiated cells, super-enhancers containing cell-type-specific master transcription factors are also found at genes that define cell identity. Super-enhancers thus play key roles in the control of mammalian cell identity.
Author	Whyte, Warren A Young, Richard A Abraham, Brian J Rahl, Peter B Orlando, David A Lin, Charles Y Lee, Tong Ihn Hnisz, Denes Kagey, Michael H
Author_xml	– sequence: 1 givenname: Warren A surname: Whyte fullname: Whyte, Warren A organization: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA – sequence: 2 givenname: David A surname: Orlando fullname: Orlando, David A – sequence: 3 givenname: Denes surname: Hnisz fullname: Hnisz, Denes – sequence: 4 givenname: Brian J surname: Abraham fullname: Abraham, Brian J – sequence: 5 givenname: Charles Y surname: Lin fullname: Lin, Charles Y – sequence: 6 givenname: Michael H surname: Kagey fullname: Kagey, Michael H – sequence: 7 givenname: Peter B surname: Rahl fullname: Rahl, Peter B – sequence: 8 givenname: Tong Ihn surname: Lee fullname: Lee, Tong Ihn – sequence: 9 givenname: Richard A surname: Young fullname: Young, Richard A
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23582322$$D View this record in MEDLINE/PubMed
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References	2405489 - Science. 1990 Feb 9;247(4943):710-2 18927605 - PLoS Comput Biol. 2008 Oct;4(10):e1000201 21540844 - Nat Cell Biol. 2011 May;13(5):490-6 10827957 - Science. 2000 May 26;288(5470):1439-41 19345177 - Cell Stem Cell. 2009 May 8;4(5):403-15 20629179 - Stem Cells. 2010 Sep;28(9):1487-97 12853946 - Nature. 2003 Jul 10;424(6945):147-51 22955617 - Nature. 2012 Sep 6;489(7414):75-82 9659909 - Mol Cell. 1997 Dec;1(1):119-29 21160473 - Nature. 2011 Feb 10;470(7333):279-83 16518401 - Nat Genet. 2006 Apr;38(4):431-40 21106759 - Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6 21330129 - Curr Opin Genet Dev. 2011 Apr;21(2):225-30 21358745 - Nat Rev Genet. 2011 Apr;12(4):283-93 18358816 - Cell. 2008 Mar 21;132(6):1049-61 22763441 - Nature. 2012 Aug 2;488(7409):116-20 20720539 - Nature. 2010 Sep 23;467(7314):430-5 20602434 - Eur J Immunol. 2010 Sep;40(9):2599-607 23103132 - Immunity. 2012 Nov 16;37(5):813-26 7731812 - Nucleic Acids Res. 1995 Mar 25;23(6):975-81 16904174 - Cell. 2006 Aug 25;126(4):663-76 23213261 - Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21028-33 7774816 - Genes Dev. 1995 Apr 15;9(8):995-1008 21451524 - Nature. 2011 May 19;473(7347):389-93 22934649 - Annu Rev Genet. 2012;46:43-68 2748593 - Proc Natl Acad Sci U S A. 1989 Jul;86(14):5434-8 16719718 - Annu Rev Genomics Hum Genet. 2006;7:29-59 17218319 - J Biol Chem. 2007 Mar 2;282(9):6316-23 22495300 - Nature. 2012 May 17;485(7398):376-80 23040478 - Cell Stem Cell. 2012 Oct 5;11(4):491-504 3690667 - Cell. 1987 Dec 24;51(6):975-85 17582344 - Immunity. 2007 Jun;26(6):715-25 22996553 - Nature. 2012 Sep 20;489(7416):391-9 15788452 - Development. 2005 May;132(9):2093-102 20940737 - Nat Rev Genet. 2010 Nov;11(11):761-72 16325584 - Cell. 2005 Dec 2;123(5):917-29 18555785 - Cell. 2008 Jun 13;133(6):1106-17 23609410 - Nat Rev Genet. 2013 Jun;14(6):367 21663790 - Cell. 2011 Jun 10;145(6):835-50 22955621 - Nature. 2012 Sep 6;489(7414):109-13 8548797 - Cell. 1995 Dec 29;83(7):1091-100 22239649 - Ann N Y Acad Sci. 2012 Jan;1247:16-33 10882104 - Mol Cell. 2000 Apr;5(4):683-93 2225071 - Cell. 1990 Nov 16;63(4):665-72 19136965 - Nat Cell Biol. 2009 Feb;11(2):197-203 18264089 - Nat Cell Biol. 2008 Mar;10(3):353-60 1924319 - Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8597-601 20888037 - Cell. 2010 Oct 15;143(2):212-24 18581335 - Eur J Immunol. 2008 Jul;38(7):1788-94 23019124 - Genes Dev. 2012 Oct 15;26(20):2286-98 18206362 - Curr Opin Struct Biol. 2008 Apr;18(2):236-42 23040477 - Cell Stem Cell. 2012 Oct 5;11(4):477-90 22297846 - Nature. 2012 Feb 9;482(7384):221-5 7958890 - Genes Dev. 1994 Sep 15;8(18):2212-26 20347762 - Dev Biol. 2010 Jun 15;342(2):146-56 18614019 - Cell. 2008 Jul 11;134(1):162-74 22868264 - Nat Rev Genet. 2012 Sep;13(9):613-26 22950945 - Genome Biol. 2012;13(9):R48 3124106 - Proc Natl Acad Sci U S A. 1988 Jan;85(2):382-6 18538592 - Immunity. 2008 Jun;28(6):751-62 1383273 - J Clin Invest. 1992 Oct;90(4):1513-22 21844366 - Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14163-8 15930108 - Development. 2005 Jun;132(12):2685-95 19261174 - Genome Biol. 2009;10(3):R25 18798982 - Genome Biol. 2008;9(9):R137 9489694 - Cell. 1998 Jan 9;92(1):5-8 20657582 - Nat Biotechnol. 2010 Aug;28(8):817-25 22608086 - Cell. 2012 Jun 8;149(6):1368-80 22955616 - Nature. 2012 Sep 6;489(7414):57-74 19295514 - Nature. 2009 May 7;459(7243):108-12 15896740 - Trends Biochem Sci. 2005 May;30(5):235-9 16484492 - Science. 2006 Feb 17;311(5763):992-6 21414485 - Cell. 2011 Mar 18;144(6):940-54 19212405 - Nature. 2009 Feb 12;457(7231):854-8 2249769 - Genes Dev. 1990 Oct;4(10):1637-49 7889409 - Immunity. 1994 Jun;1(3):207-17 16153702 - Cell. 2005 Sep 23;122(6):947-56 19339689 - Genes Dev. 2009 Apr 1;23(7):837-48 21295696 - Cell. 2011 Feb 4;144(3):327-39 21839847 - Semin Cell Dev Biol. 2011 Sep;22(7):759-68 20543837 - Nat Immunol. 2010 Jul;11(7):635-43 17989215 - Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18097-102
References_xml	– reference: 22950945 - Genome Biol. 2012;13(9):R48 – reference: 22955621 - Nature. 2012 Sep 6;489(7414):109-13 – reference: 16325584 - Cell. 2005 Dec 2;123(5):917-29 – reference: 2225071 - Cell. 1990 Nov 16;63(4):665-72 – reference: 22297846 - Nature. 2012 Feb 9;482(7384):221-5 – reference: 16484492 - Science. 2006 Feb 17;311(5763):992-6 – reference: 23040477 - Cell Stem Cell. 2012 Oct 5;11(4):477-90 – reference: 23103132 - Immunity. 2012 Nov 16;37(5):813-26 – reference: 18206362 - Curr Opin Struct Biol. 2008 Apr;18(2):236-42 – reference: 20720539 - Nature. 2010 Sep 23;467(7314):430-5 – reference: 7958890 - Genes Dev. 1994 Sep 15;8(18):2212-26 – reference: 15788452 - Development. 2005 May;132(9):2093-102 – reference: 20543837 - Nat Immunol. 2010 Jul;11(7):635-43 – reference: 22955616 - Nature. 2012 Sep 6;489(7414):57-74 – reference: 3124106 - Proc Natl Acad Sci U S A. 1988 Jan;85(2):382-6 – reference: 16719718 - Annu Rev Genomics Hum Genet. 2006;7:29-59 – reference: 18798982 - Genome Biol. 2008;9(9):R137 – reference: 3690667 - Cell. 1987 Dec 24;51(6):975-85 – reference: 15896740 - Trends Biochem Sci. 2005 May;30(5):235-9 – reference: 7774816 - Genes Dev. 1995 Apr 15;9(8):995-1008 – reference: 21663790 - Cell. 2011 Jun 10;145(6):835-50 – reference: 22763441 - Nature. 2012 Aug 2;488(7409):116-20 – reference: 2249769 - Genes Dev. 1990 Oct;4(10):1637-49 – reference: 16904174 - Cell. 2006 Aug 25;126(4):663-76 – reference: 21358745 - Nat Rev Genet. 2011 Apr;12(4):283-93 – reference: 16518401 - Nat Genet. 2006 Apr;38(4):431-40 – reference: 21160473 - Nature. 2011 Feb 10;470(7333):279-83 – reference: 20940737 - Nat Rev Genet. 2010 Nov;11(11):761-72 – reference: 23609410 - Nat Rev Genet. 2013 Jun;14(6):367 – reference: 7731812 - Nucleic Acids Res. 1995 Mar 25;23(6):975-81 – reference: 23213261 - Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21028-33 – reference: 21414485 - Cell. 2011 Mar 18;144(6):940-54 – reference: 17989215 - Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18097-102 – reference: 2748593 - Proc Natl Acad Sci U S A. 1989 Jul;86(14):5434-8 – reference: 19261174 - Genome Biol. 2009;10(3):R25 – reference: 19136965 - Nat Cell Biol. 2009 Feb;11(2):197-203 – reference: 17582344 - Immunity. 2007 Jun;26(6):715-25 – reference: 18927605 - PLoS Comput Biol. 2008 Oct;4(10):e1000201 – reference: 10827957 - Science. 2000 May 26;288(5470):1439-41 – reference: 15930108 - Development. 2005 Jun;132(12):2685-95 – reference: 21330129 - Curr Opin Genet Dev. 2011 Apr;21(2):225-30 – reference: 18538592 - Immunity. 2008 Jun;28(6):751-62 – reference: 19339689 - Genes Dev. 2009 Apr 1;23(7):837-48 – reference: 18358816 - Cell. 2008 Mar 21;132(6):1049-61 – reference: 21540844 - Nat Cell Biol. 2011 May;13(5):490-6 – reference: 19295514 - Nature. 2009 May 7;459(7243):108-12 – reference: 20602434 - Eur J Immunol. 2010 Sep;40(9):2599-607 – reference: 22996553 - Nature. 2012 Sep 20;489(7416):391-9 – reference: 9659909 - Mol Cell. 1997 Dec;1(1):119-29 – reference: 2405489 - Science. 1990 Feb 9;247(4943):710-2 – reference: 19212405 - Nature. 2009 Feb 12;457(7231):854-8 – reference: 18555785 - Cell. 2008 Jun 13;133(6):1106-17 – reference: 17218319 - J Biol Chem. 2007 Mar 2;282(9):6316-23 – reference: 1924319 - Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8597-601 – reference: 21844366 - Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14163-8 – reference: 18264089 - Nat Cell Biol. 2008 Mar;10(3):353-60 – reference: 18614019 - Cell. 2008 Jul 11;134(1):162-74 – reference: 8548797 - Cell. 1995 Dec 29;83(7):1091-100 – reference: 22608086 - Cell. 2012 Jun 8;149(6):1368-80 – reference: 20657582 - Nat Biotechnol. 2010 Aug;28(8):817-25 – reference: 20888037 - Cell. 2010 Oct 15;143(2):212-24 – reference: 18581335 - Eur J Immunol. 2008 Jul;38(7):1788-94 – reference: 22934649 - Annu Rev Genet. 2012;46:43-68 – reference: 1383273 - J Clin Invest. 1992 Oct;90(4):1513-22 – reference: 21451524 - Nature. 2011 May 19;473(7347):389-93 – reference: 22239649 - Ann N Y Acad Sci. 2012 Jan;1247:16-33 – reference: 20629179 - Stem Cells. 2010 Sep;28(9):1487-97 – reference: 21839847 - Semin Cell Dev Biol. 2011 Sep;22(7):759-68 – reference: 10882104 - Mol Cell. 2000 Apr;5(4):683-93 – reference: 21295696 - Cell. 2011 Feb 4;144(3):327-39 – reference: 23040478 - Cell Stem Cell. 2012 Oct 5;11(4):491-504 – reference: 23019124 - Genes Dev. 2012 Oct 15;26(20):2286-98 – reference: 7889409 - Immunity. 1994 Jun;1(3):207-17 – reference: 21106759 - Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6 – reference: 22495300 - Nature. 2012 May 17;485(7398):376-80 – reference: 22868264 - Nat Rev Genet. 2012 Sep;13(9):613-26 – reference: 16153702 - Cell. 2005 Sep 23;122(6):947-56 – reference: 20347762 - Dev Biol. 2010 Jun 15;342(2):146-56 – reference: 22955617 - Nature. 2012 Sep 6;489(7414):75-82 – reference: 9489694 - Cell. 1998 Jan 9;92(1):5-8 – reference: 19345177 - Cell Stem Cell. 2009 May 8;4(5):403-15 – reference: 12853946 - Nature. 2003 Jul 10;424(6945):147-51
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Snippet	Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent...
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SubjectTerms	Animals B-Lymphocytes - metabolism Cell Line Cell Lineage Embryonic Stem Cells - metabolism Enhancer Elements, Genetic Gene Expression Regulation Gene Knockdown Techniques Humans Mediator Complex - metabolism Mice Transcription Factors - metabolism Transcription, Genetic
Title	Master transcription factors and mediator establish super-enhancers at key cell identity genes
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