Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Biguanides such as metformin, which is the most widely prescribed drug for type-2 diabetes, are shown to antagonize the actions of glucagon by decreasing the levels of cyclic AMP. Antidiabetics as glucagon antagonists Hyperglycaemia is a common consequence of insulin resistance, the inability of ins...

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Bibliographic Details
Published in:	Nature (London) Vol. 494; no. 7436; pp. 256 - 260
Main Authors:	Miller, Russell A., Chu, Qingwei, Xie, Jianxin, Foretz, Marc, Viollet, Benoit, Birnbaum, Morris J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.02.2013 Nature Publishing Group
Subjects:	692/699/2743/137/773 Adenylyl Cyclases - metabolism AMP-Activated Protein Kinases - metabolism Animals Biguanides - pharmacology Care and treatment Cells, Cultured Cellular signal transduction Cyclic AMP - biosynthesis Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Diabetes Diabetes Mellitus, Type 2 - drug therapy Enzyme Activation - drug effects Glucagon Glucagon - antagonists & inhibitors Glucagon - metabolism Glucose Glucose - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Humanities and Social Sciences Hypoglycemic Agents Kinases letter Liver - cytology Liver - drug effects Liver - metabolism Metformin Metformin - pharmacology Metformin - therapeutic use Mice multidisciplinary Phenformin - pharmacology Phosphorylation Properties Proteins Rodents Science Signal Transduction - drug effects Testing France United States
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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