Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs

Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering of electrically and chemically responsive, contractile human muscle tissues (‘myobun...

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Bibliographic Details
Published in:	eLife Vol. 4; p. e04885
Main Authors:	Madden, Lauran, Juhas, Mark, Kraus, William E, Truskey, George A, Bursac, Nenad
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 09.01.2015 eLife Sciences Publications, Ltd
Subjects:	Acetylcholine - pharmacology Acetylcholine receptors Bioengineering - methods Biomechanical Phenomena - drug effects Caffeine - pharmacology Calcium Calcium - metabolism Calcium Signaling - drug effects Cell culture contractile force Drug development drug testing Electrical stimuli Genes, Reporter Human Biology and Medicine human skeletal muscle Humans Hydrogels Hypertrophy Immunoglobulins Muscle contraction Muscle Contraction - physiology muscle physiology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Musculoskeletal system Myopathy Physiology Proteins Receptor mechanisms Reproducibility of Results Rodents Skeletal muscle Tissue engineering human biology muscle physiology contractile force drug testing tissue engineering medicine human human skeletal muscle
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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