Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life

To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life. Case-control study. Not applicable. In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS...

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Veröffentlicht in:Fertility and sterility Jg. 107; H. 3; S. 788
Hauptverfasser: Pinola, Pekka, Puukka, Katri, Piltonen, Terhi T, Puurunen, Johanna, Vanky, Eszter, Sundström-Poromaa, Inger, Stener-Victorin, Elisabet, Lindén Hirschberg, Angelica, Ravn, Pernille, Skovsager Andersen, Marianne, Glintborg, Dorte, Mellembakken, Jan Roar, Ruokonen, Aimo, Tapanainen, Juha S, Morin-Papunen, Laure C
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.03.2017
Schlagworte:
Adult
Age Factors
Biomarkers - blood
Blood Glucose - metabolism
Blood Pressure
Body Mass Index
C-Reactive Protein - metabolism
Case-Control Studies
Chromatography, High Pressure Liquid
Cross-Sectional Studies
Dyslipidemias - blood
Dyslipidemias - epidemiology
Female
Glucose Metabolism Disorders - blood
Glucose Metabolism Disorders - epidemiology
Humans
Hyperandrogenism - blood
Hyperandrogenism - diagnosis
Hyperandrogenism - epidemiology
Hyperandrogenism - physiopathology
Hypertension - epidemiology
Hypertension - physiopathology
Insulin - blood
Lipids - blood
Mass Spectrometry
Metabolic Syndrome - blood
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Metabolic Syndrome - physiopathology
Metabolomics - methods
Obesity, Abdominal - epidemiology
Obesity, Abdominal - physiopathology
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - diagnosis
Polycystic Ovary Syndrome - epidemiology
Polycystic Ovary Syndrome - physiopathology
Prevalence
Reproductive Health
Scandinavian and Nordic Countries - epidemiology
Testosterone - blood
Testosterone - deficiency
Waist Circumference
Young Adult
PCOS
metabolism
hyperandrogenism
obesity
ISSN:1556-5653, 1556-5653
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Zusammenfassung:To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life. Case-control study. Not applicable. In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30-39, and >39 years). None. Body mass index (BMI), waist circumference, blood pressure, glucose, insulin, cholesterol, lipoproteins, triglycerides and high-sensitivity C-reactive protein. Both normo- and hyperandrogenic women with PCOS were more obese, especially abdominally. They had increased serum levels of insulin (fasting and in oral glucose tolerance tests), triglycerides, low-density lipoprotein, and total cholesterol, higher blood pressure, and lower high-density lipoprotein levels independently from BMI compared with the control population as early as from young adulthood until menopause. The prevalence of metabolic syndrome was two- to fivefold higher in women with PCOS compared with control women, depending on age and phenotype, and the highest prevalence was observed in hyperandrogenic women with PCOS at late reproductive age. When evaluating metabolic risks in women with PCOS, androgenic status, especially abdominal obesity and age, should be taken into account, which would allow tailored management of the syndrome from early adulthood on.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1556-5653
1556-5653
DOI:10.1016/j.fertnstert.2016.12.017