Phase separation organizes the site of autophagosome formation

Many biomolecules undergo liquid–liquid phase separation to form liquid-like condensates that mediate diverse cellular functions 1 , 2 . Autophagy is able to degrade such condensates using autophagosomes—double-membrane structures that are synthesized de novo at the pre-autophagosomal structure (PAS...

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Bibliographic Details
Published in:	Nature (London) Vol. 578; no. 7794; pp. 301 - 305
Main Authors:	Fujioka, Yuko, Alam, Jahangir Md, Noshiro, Daisuke, Mouri, Kazunari, Ando, Toshio, Okada, Yasushi, May, Alexander I., Knorr, Roland L., Suzuki, Kuninori, Ohsumi, Yoshinori, Noda, Nobuo N.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.02.2020 Nature Publishing Group
Subjects:	13/1 14/19 14/33 14/35 631/57/2267 631/80/39 631/80/458 82/83 Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Autophagosomes - chemistry Autophagosomes - metabolism Autophagy Autophagy (Cytology) Autophagy-Related Proteins - chemistry Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Biomolecules Condensates Droplets Experiments Fragility Humanities and Social Sciences Kinases Liquid phases Localization Mechanistic Target of Rapamycin Complex 1 - chemistry Mechanistic Target of Rapamycin Complex 1 - metabolism Membrane structures Membranes Microscopy multidisciplinary Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Mutation Observations Phagocytosis Phagosomes Phase separation Phase transformations (Statistical physics) Phosphorylation Physiological aspects Point Mutation Protein Binding Protein interaction Protein Kinases - chemistry Protein Kinases - genetics Protein Kinases - metabolism Proteins Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary) Vacuoles - metabolism Yeast fungi Japan
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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