Regulation of lncRNA and Its Role in Cancer Metastasis

Metastasis is the primary cause of cancer-related death all over the world. Metastasis is a process by which cancer spreads from the place at which it first arose to distant locations in the body. It is well known that several steps are necessary for this process, including cancer cell epithelial-me...

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Vydáno v:Oncology research Ročník 23; číslo 5; s. 205
Hlavní autoři: Li, Juan, Meng, Hui, Bai, Yun, Wang, Kai
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 13.04.2016
Témata:
Animals
Humans
Neoplasm Metastasis
Neoplasms - genetics
Neoplasms - pathology
RNA, Long Noncoding - genetics
ISSN:1555-3906, 1555-3906
On-line přístup:Zjistit podrobnosti o přístupu
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Shrnutí:Metastasis is the primary cause of cancer-related death all over the world. Metastasis is a process by which cancer spreads from the place at which it first arose to distant locations in the body. It is well known that several steps are necessary for this process, including cancer cell epithelial-mesenchymal transition (EMT), cell migration, resistance to anoikis, and angiogenesis. Therefore, investigating the molecular mechanism of regulating cancer metastasis progress may provide helpful insights in the development of efficient diagnosis and therapeutic strategy. Recent studies have indicated that long noncoding RNAs (lncRNAs) play important roles in cancer metastasis. lncRNAs are the nonprotein coding RNAs that have a size longer than 200 nucleotides. More and more studies have indicated that lncRNAs are involved in a broad range of biological processes and are associated with many diseases, such as cancer. The role of lncRNAs in cancer metastasis has been widely studied; however, lncRNAs are mainly involved in the EMT process on the current literature. This review focuses on the mechanisms underlying the role of lncRNAs in cancer metastasis.
Bibliografie:ObjectType-Article-1
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ISSN:1555-3906
1555-3906
DOI:10.3727/096504016X14549667334007