role of interactions between phage and bacterial proteins within the infected cell: a diverse and puzzling interactome

Interactions between bacteriophage proteins and bacterial proteins are important for efficient infection of the host cell. The phage proteins involved in these bacteriophage-host interactions are often produced immediately after infection. A survey of the available set of published bacteriophage-hos...

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Bibliographic Details
Published in:Environmental microbiology Vol. 11; no. 11; pp. 2789 - 2805
Main Authors: Roucourt, Bart, Lavigne, Rob
Format: Journal Article
Language:English
Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.11.2009
Blackwell Publishing Ltd
Subjects:
Bacteria
Bacteria - virology
bacterial proteins
Bacterial Proteins - metabolism
bacteriophages
Bacteriophages - physiology
defense mechanisms
Host-Parasite Interactions
hosts
metabolism
physiology
Protein Interaction Mapping
surveys
therapeutics
Viral Proteins
Viral Proteins - metabolism
virology
ISSN:1462-2912, 1462-2920, 1462-2920
Online Access:Get full text
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Summary:Interactions between bacteriophage proteins and bacterial proteins are important for efficient infection of the host cell. The phage proteins involved in these bacteriophage-host interactions are often produced immediately after infection. A survey of the available set of published bacteriophage-host interactions reveals the targeted host proteins are inhibited, activated or functionally redirected by the phage protein. These interactions protect the bacteriophage from bacterial defence mechanisms or adapt the host-cell metabolism to establish an efficient infection cycle. Regrettably, a large majority of bacteriophage early proteins lack any identified function. Recent research into the antibacterial potential of bacteriophage-host interactions indicates that phage early proteins seem to target a wide variety of processes in the host cell - many of them non-essential. Since a clear understanding of such interactions may become important for regulations involving phage therapy and in biotechnological applications, increased scientific emphasis on the biological elucidation of such proteins is warranted.
Bibliography:http://dx.doi.org/10.1111/j.1462-2920.2009.02029.x
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ArticleID:EMI2029
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ObjectType-Feature-2
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ISSN:1462-2912
1462-2920
1462-2920
DOI:10.1111/j.1462-2920.2009.02029.x