A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

Protein–metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein–lipid interactions in yeast. We used arrays of 56 metabolites to measure lipid‐binding fingerprints of 172 proteins, including 91 with predicted lipid‐binding d...

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Veröffentlicht in:	Molecular systems biology Jg. 6; H. 1; S. 430 - n/a
Hauptverfasser:	Gallego, Oriol, Betts, Matthew J, Gvozdenovic‐Jeremic, Jelena, Maeda, Kenji, Matetzki, Christian, Aguilar‐Gurrieri, Carmen, Beltran‐Alvarez, Pedro, Bonn, Stefan, Fernández‐Tornero, Carlos, Jensen, Lars Juhl, Kuhn, Michael, Trott, Jamie, Rybin, Vladimir, Müller, Christoph W, Bork, Peer, Kaksonen, Marko, Russell, Robert B, Gavin, Anne‐Claude
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 30.11.2010 John Wiley & Sons, Ltd EMBO Press Nature Publishing Group Springer Nature
Schlagworte:	Actin Algorithms Baking yeast Binding E coli EMBO20 EMBO37 Enzymes Fatty Acid-Binding Proteins - analysis Fatty Acid-Binding Proteins - chemistry Fatty Acid-Binding Proteins - metabolism High-Throughput Screening Assays - methods Homology interactome Kinases Lipid Metabolism - physiology Lipid-Linked Proteins - analysis Lipid-Linked Proteins - chemistry Lipid-Linked Proteins - metabolism Lipids Lipids - analysis lipid‐array Membranes Metabolism Metabolites Metabolome Mode of action Models, Biological network Phosphates Phosphatidylinositol Phosphatidylinositol phosphates Pleckstrin pleckstrin homology domains Protein Array Analysis - methods Protein Binding Protein Interaction Domains and Motifs - physiology Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - analysis Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Sphingolipids Validation Studies as Topic Yeast pleckstrin homology domains interactome lipid‐array sphingolipids network
ISSN:	1744-4292, 1744-4292
Online-Zugang:	Volltext
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