NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis

Background Silicosis is a progressive and often fatal occupational lung disease. The NLRP3 inflammasome is an innate immune sensor that is activated by silica. Accumulating evidence has implicated a role for NLRP3 in silicosis pathogenesis. In this study, we mechanistically elucidated the contributi...

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Bibliographic Details
Published in:	Respiratory research Vol. 26; no. 1; pp. 109 - 17
Main Authors:	Lam, Maggie, Barry, Kristian T., Hodges, Christopher J., Harpur, Christopher M., Ong, James D. H., Rosli, Sarah, West, Alison C., Dousha, Lovisa, Hertzog, Paul J., Mansell, Ashley, Tate, Michelle D.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 21.03.2025 BioMed Central Ltd Nature Publishing Group BMC
Subjects:	Actin Animals Cell activation Complications and side effects Damage Development and progression Elastase Fibrosis Growth factors Health aspects Histopathology In vivo methods and tests Infiltration Inflammasomes Inflammasomes - metabolism Inflammation Intranasal administration Lasers Leukocytes (neutrophilic) Lung - drug effects Lung - immunology Lung - metabolism Lung - pathology Lung diseases Lung nodules Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Mouse model Neutrophil Infiltration - drug effects Neutrophil Infiltration - physiology Neutrophils NLR Family, Pyrin Domain-Containing 3 Protein - deficiency NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLRP3 NLRP3 inflammasome Nodules Occupational diseases Pathogenesis Pneumology/Respiratory System Protein expression Proteins Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control Silica Silica dust Silicon dioxide Silicon Dioxide - administration & dosage Silicon Dioxide - toxicity Silicosis Silicosis - genetics Silicosis - metabolism Silicosis - pathology Smooth muscle Stem cells Australia United States > US Mouse model Inflammation NLRP3 inflammasome Silicosis Fibrosis
ISSN:	1465-993X, 1465-9921, 1465-993X
Online Access:	Get full text
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