Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells and facilitating the selection of virus-specific antibodies. However, neither the dynamics and cross-reactivity of the SARS-CoV-2-specific T...

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Bibliographic Details
Published in:	eLife Vol. 10
Main Authors:	Minervina, Anastasia A, Komech, Ekaterina A, Titov, Aleksei, Bensouda Koraichi, Meriem, Rosati, Elisa, Mamedov, Ilgar Z, Franke, Andre, Efimov, Grigory A, Chudakov, Dmitriy M, Mora, Thierry, Walczak, Aleksandra M, Lebedev, Yuri B, Pogorelyy, Mikhail V
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 05.01.2021 eLife Sciences Publications Ltd eLife Sciences Publication eLife Sciences Publications, Ltd
Subjects:	Amino Acid Sequence Antibodies Antigens Antiviral agents Antiviral drugs B cells CD4 antigen CD8 antigen Cloning Computational and Systems Biology Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - physiopathology COVID-19 vaccines Cross Reactions Cross-reactivity Epidemics Epitope Mapping Female Fever Gene Library Genotype & phenotype Health aspects Histocompatibility Testing Humans Immune response Immunologic Memory Immunological memory Immunology and Inflammation Infection Infections Life Sciences Longitudinal Studies Lymphocytes Lymphocytes T Male Memory cells Pandemics Peptides Phenotypes Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - genetics RepSeq SARS-CoV-2 SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Short Report T cell receptors T cells T-Lymphocytes - immunology TCR Viral antibodies Viral infections COVID-19 computational biology systems biology RepSeq SARS-CoV-2 TCR inflammation human immunology
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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